Literature summary for 4.2.1.159 extracted from

Useglio, M.; Peiru, S.; Rodriguez, E.; Labadie, G.R.; Carney, J.R.; Gramajo, H.
TDP-L-megosamine biosynthesis pathway elucidation and megalomicin a production in Escherichia coli (2010), Appl. Environ. Microbiol., 76, 3869-3877.

Search for more literature for 4.2.1.159

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Micromonospora megalomicea

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose	Micromonospora megalomicea	-	dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O	enzyme MegBVI is involved in the C-2 deoxygenation step during the biosynthesis of TDP-L-mycarose, generating the intermediate TDP-2,6-dideoxy-3,4-dioxo-D-glucose	?

Organism

Organism	UniProt	Comment	Textmining
Micromonospora megalomicea	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose	-	Micromonospora megalomicea	dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O	enzyme MegBVI is involved in the C-2 deoxygenation step during the biosynthesis of TDP-L-mycarose, generating the intermediate TDP-2,6-dideoxy-3,4-dioxo-D-glucose	?

Synonyms

Synonyms	Comment	Organism
megBVI	-	Micromonospora megalomicea

General Information

General Information	Comment	Organism
physiological function	production of TDP-L-megosamine from TDP-4-keto-6-deoxy-D-glucose requires only five biosynthetic steps, catalyzed by MegBVI, MegDII, MegDIII, MegDIV, and MegDV	Micromonospora megalomicea

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Release 2023.1 (January 2023)