Literature summary for 4.2.1.144 extracted from

Floss, H.G.; Yu, T.W.; Arakawa, K.
The biosynthesis of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of mC7N units in ansamycin and mitomycin antibiotics: a review (2011), J. Antibiot., 64, 35-44.

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Organism

Organism	UniProt	Comment	Textmining
Amycolatopsis mediterranei	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5-amino-5-deoxy-3-dehydroshikimate	-	Amycolatopsis mediterranei	3-amino-5-hydroxybenzoate + H2O	-	?

General Information

General Information	Comment	Organism
physiological function	enzyme is part of the aminoshikimate pathway of formation of 3-amino-5-hydroxybenzoic acid, the precursor of ansamycin and other antibiotics. Nitrogenous precursor Kanosamine is phosphorylated and converted into 1-deoxy-1-imino-erythrose 4-phosphate, the substrate for the formation of 3,4-dideoxy-4-amino-D-arabino-seduheptulosonic acid 7-phosphate. This is converted via 5-deoxy-5-aminodehydroquinic acid and 5-deoxy-5-aminodehydroshikimic acid into 3-amino-5-hydroxybenzoic acid. 3-amino-5-hydroxybenzoic acid synthase seems to have two catalytic functions. As a homodimer, it catalyzes the last reaction in the pathway, the aromatization of 5-deoxy-5-aminodehydroshikimic acid, and at the beginning of the pathway in a complex with the oxidoreductase RifL it catalyzes the transamination of UDP-3-keto-D-glucose	Amycolatopsis mediterranei

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Release 2023.1 (January 2023)