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Literature summary for 4.2.1.142 extracted from
- Involvement of two cytosolic enzymes and a novel intermediate, 5-oxoaverantin, in the pathway from 5-hydroxyaverantin to averufin in aflatoxin biosynthesis (2003), Appl. Environ. Microbiol., 69, 6418-6426.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.02 | - |
5'-oxoaverantin | pH 7.5, 30°C | Aspergillus parasiticus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Aspergillus parasiticus | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 79000 | - |
2 * 79000, SDS-PAGE | Aspergillus parasiticus |
| 158000 | - |
gel filtration | Aspergillus parasiticus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aspergillus parasiticus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Aspergillus parasiticus |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0836 | - |
pH 7.5, 30°C | Aspergillus parasiticus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5'-oxoaverantin | i.e. 1,3,6,8-tetrahydroxy-2-[(1S)-1-hydroxy-5-oxohexyl]anthracene-9,10-dione | Aspergillus parasiticus | (2'S,5'S)-averufin + H2O | i.e. 7,9,11-trihydroxy-2-methyl-3,4,5,6-tetrahydro-2,6-epoxy-2H-anthra[2,3-b]oxocin-8,13-dione | ? | |
| 5'-oxoaverantin | i.e. 1,3,6,8-tetrahydroxy-2-[(1S)-1-hydroxy-5-oxohexyl]anthracene-9,10-dione | Aspergillus parasiticus NIAH-26 | (2'S,5'S)-averufin + H2O | i.e. 7,9,11-trihydroxy-2-methyl-3,4,5,6-tetrahydro-2,6-epoxy-2H-anthra[2,3-b]oxocin-8,13-dione | ? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 79000, SDS-PAGE | Aspergillus parasiticus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| OAVN cyclase | - |
Aspergillus parasiticus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | 45 | broad | Aspergillus parasiticus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 7 | - |
Aspergillus parasiticus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no requirement for NAD(H) or NADP(H) | Aspergillus parasiticus |
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Release 2023.1 (January 2023)
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