Protein Variants | Comment | Organism |
---|---|---|
additional information | the skl mutant of strain A17 shows no induction of the enzyme, or amounts of medicarpin or 7,4'-dihydroxyflavone, by ethylene, but accumulates isoprenoid precursors of the defense molecules, e.g. the precursor of medicarpin. Overexpression of the isoflavonoid pathway increases the resistance against root pathogen Rhizoctonia solani strain AG8. No compensation of the phenotype by medicarpin addition | Medicago truncatula |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
7,2'-dihydroxy-4'-methoxyisoflavanol | Medicago truncatula | - |
(-)-medicarpin + H2O | - |
? | |
7,2'-dihydroxy-4'-methoxyisoflavanol | Medicago truncatula A17 | - |
(-)-medicarpin + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Medicago truncatula | - |
- |
- |
Medicago truncatula A17 | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
root | - |
Medicago truncatula | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7,2'-dihydroxy-4'-methoxyisoflavanol | - |
Medicago truncatula | (-)-medicarpin + H2O | - |
? | |
7,2'-dihydroxy-4'-methoxyisoflavanol | - |
Medicago truncatula A17 | (-)-medicarpin + H2O | - |
? |
Organism | Comment | Expression |
---|---|---|
Medicago truncatula | the enzyme expression is induced in roots by ethylene | up |
General Information | Comment | Organism |
---|---|---|
malfunction | the ethylene-insensitive strain A17 mutant sickle (skl) with a point mutation in the EIN2 gene is highly susceptible to Rhizoctonia solani strain AG8 and shows no transcriptional response of the isoflavonoid-related genes. The skl mutant of strain A17 shows no induction of the amounts of medicarpin or 7,4'-dihydroxyflavone, by ethylene, but accumulates isoprenoid precursors of the defense molecules, e.g. the precursor of medicarpin. Overexpression of the isoflavonoid pathway increases the resistance against root pathogen Rhizoctonia solani strain AG8. No compensation of the phenotype by medicarpin addition | Medicago truncatula |
physiological function | strain A17 shows accumulation of phytoalexin medicarpin, as well as of other isoflavonoid-related compounds like liquiritigenin, formononetin, and biochanin A. The strain is resistant against Rhizoctonia solani infection. Medicarpin is derived from the isoflavonoid-based biosynthesis pathway and involved in plant defense. Rhizoctonia solani strain AG8 infection induces the defense genes by production of ethylene. The enzyme is involved in ethylene-iduced plant defense against root pathogens | Medicago truncatula |