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Literature summary for 4.2.1.127 extracted from

  • Lueddeke, F.; Dikfidan, A.; Harder, J.
    Physiology of deletion mutants in the anaerobic beta-myrcene degradation pathway in Castellaniella defragrans (2012), BMC Microbiol., 12, 192.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.1.127

Protein Variants

Protein Variants Comment Organism
additional information generation of an in-frame deletion mutants Castellaniella defragrans DELTAldi Castellaniella defragrans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
beta-myrcene + H2O Castellaniella defragrans
-
 (3S)-linalool
-
 ?
beta-myrcene + H2O Castellaniella defragrans 65Phen
-
 (3S)-linalool
-
 ?

Organism

Organism UniProt Comment Textmining
Castellaniella defragrans E1XUJ2 i.e. Alcaligenes defragrans, gene ldi
-
Castellaniella defragrans 65Phen E1XUJ2 i.e. Alcaligenes defragrans, gene ldi
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-myrcene + H2O
-
 Castellaniella defragrans (3S)-linalool
-
 ?
beta-myrcene + H2O
-
 Castellaniella defragrans 65Phen (3S)-linalool
-
 ?

Synonyms

Synonyms Comment Organism
LDI
-
 Castellaniella defragrans
ldi/LDI
-
 Castellaniella defragrans
linalool dehydratase-isomerase
-
 Castellaniella defragrans

General Information

General Information Comment Organism
malfunction deletion of gene ldi affects growth on acyclic monoterpenes, e.g. beta-myrcene, phenotype, overview Castellaniella defragrans
metabolism the bifunctional linalool dehydratase-isomerase ldi/LDI is the initial enzyme in the anaerobic beta-myrcene degradation pathway and catalyzes the hydration of beta-myrcene to (S)-(+)-linalool and its isomerization to geraniol. A high-affinity geraniol dehydrogenase geoA/GeDH and a geranial dehydrogenase geoB/GaDH contribute to the formation of geranic acid Castellaniella defragrans
additional information growth on cyclic monoterpenes independent of the initial enzyme linalool dehydratase suggests the presence of a second enzyme system activating unsaturated hydrocarbons Castellaniella defragrans
physiological function essential requirement of the linalool dehydratase-isomerase for growth on acyclic monoterpenes, e.g. beta-myrcene, but not on cyclic monoterpenes, e.g. cyclic alpha-phellandrene or limonene Castellaniella defragrans