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Literature summary for 4.2.1.125 extracted from

  • Han, J.Y.; Wang, H.Y.; Choi, Y.E.
    Production of dammarenediol-II triterpene in a cell suspension culture of transgenic tobacco (2014), Plant Cell Rep., 33, 225-233.
    View publication on PubMed
Search for more literature for 4.2.1.125

Application

Application Comment Organism
synthesis the production of dammarenediol-II in a cell suspension culture of transgenic tobacco can be applied to the large-scale production of this compound and utilized as a source of pharmacologically active medicinal materials Panax ginseng

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression in Nicotiana tabacum cv. Xanthi leaves using transfection via Agrobacterium tumefaciens strain LBA4404, accumulation of dammarenediol-II in transgenic tobacco plants occurred in an organ-specific manner in descending order: roots, stems, leaves, flower buds, and transgenic cell suspension line 14 exhibits a high amount, overview Panax ginseng

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(3S)-2,3-epoxy-2,3-dihydrosqualene + H2O Panax ginseng
-
 dammarenediol II
-
 ?

Organism

Organism UniProt Comment Textmining
Panax ginseng Q08IT1 gene PgDDS1
-

Source Tissue

Source Tissue Comment Organism Textmining
root
-
 Panax ginseng
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(3S)-2,3-epoxy-2,3-dihydrosqualene + H2O
-
 Panax ginseng dammarenediol II
-
 ?

Synonyms

Synonyms Comment Organism
dammarenediol-II synthase
-
 Panax ginseng
PgDDS1
-
 Panax ginseng

Expression

Organism Comment Expression
Panax ginseng induction by methyl jasmonate, overview up

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the first step in the biosynthetic pathway for ginsenosides in Panax ginseng, overview Panax ginseng
physiological function dammarenediol-II synthase catalyzes the cyclization of 2,3-oxidosqualene to dammarenediol-II, which is the basic triterpene skeleton in dammarene-type saponin (ginsenosides) in Panax ginseng. Dammarenediol-II is present in the roots of Panax ginseng in trace amounts because it is an intermediate product in triterpene biosynthesis Panax ginseng