Literature summary for 4.2.1.123 extracted from

Xu, F.; Jerlstroem-Hultqvist, J.; Kolisko, M.; Simpson, A.; Roger, A.; Svaerd, S.; Andersson, J.
On the reversibility of parasitism adaptation to a free-living lifestyle via gene acquisitions in the diplomonad Trepomonas sp. PC1 (2016), BMC Biol., 14, 62 .

Search for more literature for 4.2.1.123

Application

Application	Comment	Organism
diagnostics	tetrahymanol is a polycyclic triterpenoid lipid in the Tetrahymena ciliates. The diagenetic product, gammacerane, is often used as a biomarker for water column stratification in ancient ecosystems	Trepomonas sp. PC1

Cloned(Commentary)

Cloned (Comment)	Organism
gene TPC1_17222, sequence comparisons and phylogenetic analysis, transcriptome analysis	Trepomonas sp. PC1

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
squalene + H2O	Trepomonas sp. PC1	-	tetrahymanol	-	?

Organism

Organism	UniProt	Comment	Textmining
Trepomonas sp. PC1	A0A146K6G2	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
squalene + H2O	-	Trepomonas sp. PC1	tetrahymanol	-	?

Synonyms

Synonyms	Comment	Organism
squalene-tetrahymanol cyclase	-	Trepomonas sp. PC1
STC	-	Trepomonas sp. PC1
TPC1_17222	-	Trepomonas sp. PC1

General Information

General Information	Comment	Organism
evolution	phylogenetic evidence reveals that the last common ancestor of diplomonads was dependent on a host and that Trepomonas has adapted secondarily to a free-living lifestyle. Free-living taxa are nested within parasites reveals more examples of secondarily free-living eukaryotes, transcriptome study of Trepomonas sp. PC1, a diplomonad isolated from marine sediment. Phylogenetic analyses show that most of the differences in metabolic capacity between free-living Trepomonas and the parasitic diplomonads are due to recent acquisitions of bacterial genes via gene transfer. The transcriptome includes a gene encoding squalene-tetrahymanol cyclase. This enzyme synthesizes the sterol substitute tetrahymanol in the absence of oxygen, potentially allowing Trepomonas to thrive under anaerobic conditions as a free-living bacterivore, without depending on sterols from other eukaryotes	Trepomonas sp. PC1
physiological function	the enzyme synthesizes the sterol substitute tetrahymanol in the absence of oxygen, potentially allowing Trepomonas to thrive under anaerobic conditions as a free-living bacterivore, without depending on sterols from other eukaryotes. Several microbial eukaryotes that live under anoxic conditions employ the sterol substitute tetrahymanol, which can be synthesized without molecular oxygen. The Trepomonas transcriptome includes a homologue of STC, the enzyme required to synthesize tetrahymanol	Trepomonas sp. PC1

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Release 2023.1 (January 2023)