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Literature summary for 4.2.1.119 extracted from

  • Wu, L.; Lin, S.; Li, D.
    Comparative inhibition studies of enoyl-CoA hydratase 1 and enoyl-CoA hydratase 2 in long-chain fatty acid oxidation (2008), Org. Lett., 10, 3355-3358.
    View publication on PubMed
Search for more literature for 4.2.1.119

Inhibitors

Inhibitors Comment Organism Structure
(R)-methylenecyclopropylformyl-CoA methylenecyclopropylformyl-CoA is a better inhibitor for enoyl-CoA hydratase 2 than for enoyl-CoA hydratase 1 Rattus norvegicus
(S)-methylenecyclopropylformyl-CoA methylenecyclopropylformyl-CoA is a better inhibitor for enoyl-CoA hydratase 2 than for enoyl-CoA hydratase 1 Rattus norvegicus
3-octynoyl-CoA irreversible inhibitor of enoyl-CoA hydratase 2 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome
-
 Rattus norvegicus 5777
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the beta-oxidation in mitochondria involves a (3S)-hydroxyacyl-CoA intermediate, while the beta-oxidation in peroxisomes has a (3R)-hydroxyacyl-CoA intermediate. The enzymes responsible for the formation of these two different intermediates are enoyl-CoA hydratase 1 (ECH1) in mitochondria and enoyl-CoA hydratase 2 (ECH2) in peroxisomes ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the beta-oxidation in mitochondria involves a (3S)-hydroxyacyl-CoA intermediate, while the beta-oxidation in peroxisomes has a (3R)-hydroxyacyl-CoA intermediate. The enzymes responsible for the formation of these two different intermediates are enoyl-CoA hydratase 1 (ECH1) in mitochondria and enoyl-CoA hydratase 2 (ECH2) in peroxisomes Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
ECH2
-
 Rattus norvegicus
enoyl-CoA hydratase 2
-
 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.041
-
 (R)-methylenecyclopropylformyl-CoA 25°C Rattus norvegicus
0.053
-
 (S)-methylenecyclopropylformyl-CoA 25°C Rattus norvegicus
0.065
-
 3-octynoyl-CoA 25°C Rattus norvegicus