Literature summary for 4.2.1.119 extracted from

Koski, M.K.; Haapalainen, A.M.; Hiltunen, J.K.; Glumoff, T.
A two-domain structure of one subunit explains unique features of eukaryotic hydratase 2 (2004), J. Biol. Chem., 279, 24666-24672.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
structure determination. The eukaryotic hydratase 2 has a complete hot dog fold only in its C-domain, whereas the N-domain lacks a long central alpha-helix, thus creating space for bulkier substrates in the binding pocket. The hydrogen bonding network of the active site of 2-enoyl-CoA hydratase 2 resembles the active site geometry of mitochondrial (S)-specific 2-enoyl-CoA hydratase 1, although in a mirror image fashion	Candida tropicalis

Crystallization (Comment)

Organism

structure determination. The eukaryotic hydratase 2 has a complete hot dog fold only in its C-domain, whereas the N-domain lacks a long central alpha-helix, thus creating space for bulkier substrates in the binding pocket. The hydrogen bonding network of the active site of 2-enoyl-CoA hydratase 2 resembles the active site geometry of mitochondrial (S)-specific 2-enoyl-CoA hydratase 1, although in a mirror image fashion

Candida tropicalis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(2E)-2-enoyl-CoA + H2O	Candida tropicalis	2-enoyl-CoA hydratase 2 is a part of multifunctional enzyme type 2, hydrates trans-2-enoyl-CoA to 3-hydroxyacyl-CoA as a key enzyme in the (3R)-hydroxy-dependent route of peroxisomal beta-oxidation of fatty acids	(3R)-3-hydroxyacyl-CoA	-	?

Organism

Organism	UniProt	Comment	Textmining
Candida tropicalis	P22414	2-enoyl-CoA hydratase 2 is a part of multifunctional enzyme type 2	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(2E)-2-enoyl-CoA + H2O	2-enoyl-CoA hydratase 2 is a part of multifunctional enzyme type 2, hydrates trans-2-enoyl-CoA to 3-hydroxyacyl-CoA as a key enzyme in the (3R)-hydroxy-dependent route of peroxisomal beta-oxidation of fatty acids	Candida tropicalis	(3R)-3-hydroxyacyl-CoA	-	?

Synonyms

Synonyms	Comment	Organism
2-enoyl-CoA hydratase 2	is a part of multifunctional enzyme type 2	Candida tropicalis