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Literature summary for 4.2.1.11 extracted from
- Clonorchis sinensis enolase: identification and biochemical characterization of a glycolytic enzyme from excretory/secretory products (2011), Mol. Biochem. Parasitol., 177, 135-142.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| additional information | enolase as both an excretory/secretory product and a tegumental component of Clonorchis sinensis, immunohistochemical analysis | Clonorchis sinensis | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| K+ | activates, best at 2 mM | Clonorchis sinensis |  |
| Mg2+ | activates, best at 10 mM | Clonorchis sinensis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-phospho-D-glycerate | Clonorchis sinensis | - |
phosphoenolpyruvate + H2O | - |
r | |
| additional information | Clonorchis sinensis | enolase shows plasminogen-binding activity | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Clonorchis sinensis | - |
propagated in livers of male Sprague-Dawley rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| integument | adult worm | Clonorchis sinensis | - |
| additional information | enolase expression analysis in adult worm, metacercaria, cercaria and egg. Csenolase is transcribed at the four life stages of Clonorchis sinensis while showing a significant higher expression level at the stage of adult worm | Clonorchis sinensis | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-phospho-D-glycerate | - |
Clonorchis sinensis | phosphoenolpyruvate + H2O | - |
r | |
| additional information | enolase shows plasminogen-binding activity | Clonorchis sinensis | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Csenolase | - |
Clonorchis sinensis |
| enolase | - |
Clonorchis sinensis |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Clonorchis sinensis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 8 | - |
Clonorchis sinensis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | enolase is a multifunctional enzyme that is involved in the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate in glycolytic and gluconeogenesis pathways. Csenolase might play key roles in the growth of the parasites. Csenolase is an important glycolytic enzyme required for the development of Clonorchis sinensis | Clonorchis sinensis |
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Release 2023.1 (January 2023)
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