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Literature summary for 4.2.1.11 extracted from

  • Cappello, P.; Tomaino, B.; Chiarle, R.; Ceruti, P.; Novarino, A.; Castagnoli, C.; Migliorini, P.; Perconti, G.; Giallongo, A.; Milella, M.; Monsurro, V.; Barbi, S.; Scarpa, A.; Nistico, P.; Giovarelli, M.; Novelli, F.
    An integrated humoral and cellular response is elicited in pancreatic cancer by alpha-enolase, a novel pancreatic ductal adenocarcinoma-associated antigen (2009), Int. J. Cancer, 125, 639-648.
    View publication on PubMed
Search for more literature for 4.2.1.11

Application

Application Comment Organism
medicine alpha-enolase is a pancreatic ductal adenocarcinoma-associated antigen Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Homo sapiens 9986
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-phospho-D-glycerate Homo sapiens
-
 phosphoenolpyruvate + H2O
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni2+-affinity column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
CFPAC-1 cell
-
 Homo sapiens
-
K-562 cell
-
 Homo sapiens
-
MiaPaCa-2 cell
-
 Homo sapiens
-
PaCa-44 cell
-
 Homo sapiens
-
PANC-1 cell
-
 Homo sapiens
-
pancreatic ductal adenocarcinoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-phospho-D-glycerate
-
 Homo sapiens phosphoenolpyruvate + H2O
-
 r

Synonyms

Synonyms Comment Organism
alpha-enolase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens alpha-enolase is overexpressed at both mRNA and protein levels in pancreatic ductal adenocarcinoma cells up

General Information

General Information Comment Organism
physiological function alpha-enolase is a glycolytic enzyme that also acts as a surface plasminogen receptor, alpha-enolase elicits a pancreatic ductal adenocarcinoma cell-specific, integrated humoral and cellular response Homo sapiens