Literature summary for 4.2.1.107 extracted from

Novikov, D.K.; Kamps, M.E.
Characterization of the promoter region of the human peroxisomal multifunctional enzyme type 2 gene (2001), Biochem. Biophys. Res. Commun., 284, 226-231.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
peroxisome	-	Homo sapiens	5777	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O	Homo sapiens	reaction in cholic acid synthesis is catalyzed by peroxisomal multifunctional enzyme type 2. Human perMFE-2 is induced by transcription factors AP2alpha and AP2gamma and attenuated by Sp1 binding to recognition sequence located within and -151/-142 region	(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O	reaction in cholic acid synthesis is catalyzed by peroxisomal multifunctional enzyme type 2. Human perMFE-2 is induced by transcription factors AP2alpha and AP2gamma and attenuated by Sp1 binding to recognition sequence located within and -151/-142 region	Homo sapiens	(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA	-	?

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Release 2023.1 (January 2023)