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Literature summary for 4.2.1.10 extracted from

  • Frederickson, M.; Roszak, A.W.; Coggins, J.R.; Lapthorn, A.J.; Abell, C.
    (1R,4S,5R)-3-Fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases (2004), Org. Biomol. Chem., 2, 1592-1596.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(1R,4S,5R)-3,3-difluoro-1,4,5-trihydroxycyclohexane-1-carboxylic acid inhibitor is selective for the type II dehydroquinase over the type I dehydroquinase Mycobacterium tuberculosis
(1R,4S,5R)-3,3-difluoro-1,4,5-trihydroxycyclohexane-1-carboxylic acid
-
Salmonella enterica subsp. enterica serovar Typhi
(1R,4S,5R)-3,3-difluoro-1,4,5-trihydroxycyclohexane-1-carboxylic acid inhibitor is selective for the type II dehydroquinase over the type I dehydroquinase Streptomyces coelicolor
(1R,4S,5R)-3-fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid inhibitor is selective for the type II dehydroquinase over the type I dehydroquinase Mycobacterium tuberculosis
(1R,4S,5R)-3-fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid
-
Salmonella enterica subsp. enterica serovar Typhi
(1R,4S,5R)-3-fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid inhibitor is selective for the type II dehydroquinase over the type I dehydroquinase Streptomyces coelicolor

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WPX7
-
-
Mycobacterium tuberculosis H37Rv P9WPX7
-
-
Salmonella enterica subsp. enterica serovar Typhi
-
-
-
Streptomyces coelicolor P15474
-
-

Synonyms

Synonyms Comment Organism
Type I dehydroquinase
-
Salmonella enterica subsp. enterica serovar Typhi
Type II dehydroquinase
-
Streptomyces coelicolor
Type II dehydroquinase
-
Mycobacterium tuberculosis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.01
-
(1R,4S,5R)-3-fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid
-
Mycobacterium tuberculosis
0.015
-
(1R,4S,5R)-3-fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid
-
Streptomyces coelicolor
0.7
-
(1R,4S,5R)-3,3-difluoro-1,4,5-trihydroxycyclohexane-1-carboxylic acid
-
Streptomyces coelicolor
0.7
-
(1R,4S,5R)-3,3-difluoro-1,4,5-trihydroxycyclohexane-1-carboxylic acid
-
Mycobacterium tuberculosis
1.5
-
(1R,4S,5R)-3-fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid
-
Salmonella enterica subsp. enterica serovar Typhi
8
-
(1R,4S,5R)-3,3-difluoro-1,4,5-trihydroxycyclohexane-1-carboxylic acid
-
Salmonella enterica subsp. enterica serovar Typhi