Literature summary for 4.2.1.1 extracted from

Ip, Y.K.; Koh, C.Z.Y.; Hiong, K.C.; Choo, C.Y.L.; Boo, M.V.; Wong, W.P.; Neo, M.L.; Chew, S.F.
Carbonic anhydrase 2-like in the giant clam, Tridacna squamosa characterization, localization, response to light, and possible role in the transport of inorganic carbon from the host to its symbionts (2017), Physiol. Rep., 5, e13494 .

Search for more literature for 4.2.1.1

Cloned(Commentary)

Cloned (Comment)	Organism
gene CA2, cloned from DNA of outer and inner mantle, DNA and amino acid sequence determination and analysis, no nucleotide polymorphism is observed between the CA2-like cDNA sequences obtained from these two tissues, phylogenetic analysis, quantitative real-time PCR expression analysis of CA2-like	Tridacna squamosa

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Tridacna squamosa	16020	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	essential for the catalytic activity, metalloenzyme	Tridacna squamosa

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
H2CO3	Tridacna squamosa	-	CO2 + H2O	-	r

Organism

Organism	UniProt	Comment	Textmining
Tridacna squamosa	A0A2R2Y2Q1	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
mantle	-	Tridacna squamosa	-
additional information	the outer mantle, which contains the highest density of tertiary tubules and exosymbiont zooxanthellae, displays high level of CA2-like expression, and CA2-like is localized to the tubule epithelial cells. Cloning of CA2 homolog (CA2-like) from the fleshy and colorful outer mantle as well as the thin and whitish inner mantle of Tridacna squamosa to determine its cellular and subcellular localization. Immunofluorescent enzyme localization study	Tridacna squamosa	-
renal tubule epithelium	-	Tridacna squamosa	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
H2CO3	-	Tridacna squamosa	CO2 + H2O	-	r

Subunits

Subunits	Comment	Organism
?	x * 29600, about, sequence calculation	Tridacna squamosa

Synonyms

Synonyms	Comment	Organism
alpha-CA	-	Tridacna squamosa
CA2	-	Tridacna squamosa
CA2 homolog	-	Tridacna squamosa
CA2-like	-	Tridacna squamosa
carbonic anhydrase 2	-	Tridacna squamosa
dual domain-carbonic anhydrase	-	Tridacna squamosa

Expression

Organism	Comment	Expression
Tridacna squamosa	exposure to light induces significant increases in the protein abundance of CA2-like in the outer mantle	up

General Information

General Information	Comment	Organism
additional information	the residues essential for CA2 catalytic activity are highly conserved, and also the hydrophobic portion of the CA2 active site (Val129, Val150, Leu209, Val218 and Trp220) and responsible for binding the substrate CO2 are fully conserved, active site structure	Tridacna squamosa
physiological function	CA2-like can probably take part in the increased supply of inorganic carbon (Ci) from the host clam to the symbiotic zooxanthellae when the latter conduct photosynthesis to fix Ci during light exposure	Tridacna squamosa

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)