Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,3-dimethylpyrimidine-2,4(1H,3H)-dione | inhibition of isozyme hCA I; inhibition of isozyme hCA II | Homo sapiens | |
5,6-diamino-1,3-dimethyluracil | inhibition of isozyme hCA I; inhibition of isozyme hCA II | Homo sapiens | |
5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione | inhibition of isozyme hCA I | Homo sapiens | |
5-bromo-1-(4-methylbenzene-1-sulfonyl)pyrimidine-2,4(1H,3H)-dione | inhibition of isozyme hCA I; inhibition of isozyme hCA II | Homo sapiens | |
5-bromo-1-(methanesulfonyl)pyrimidine-2,4(1H,3H)-dione | inhibition of isozyme hCA I; inhibition of isozyme hCA II | Homo sapiens | |
5-fluorouracil | - |
Homo sapiens | |
6-amino-1,3-dimethyluracil | inhibition of isozyme hCA I; inhibition of isozyme hCA II | Homo sapiens | |
6-amino-5-bromouracil | - |
Homo sapiens | |
6-amino-5-chlorouracil | - |
Homo sapiens | |
6-methylpyrimidine-2,4(1H,3H)-dione | inhibition of isozyme hCA I | Homo sapiens | |
Benzene | - |
Homo sapiens | |
benzene-1,2-diol | inhibition of isozyme hCA I | Homo sapiens | |
benzene-1,3-diol | inhibition of isozyme hCA I | Homo sapiens | |
catechol | inhibition of isozyme hCA II | Homo sapiens | |
Isoorotic acid | inhibition of isozyme hCA I; inhibition of isozyme hCA II | Homo sapiens | |
additional information | some uracil derivatives have carbonic anhydrase inhibitory properties, overview; some uracil derivatives have carbonic anhydrase inhibitory properties, overview | Homo sapiens | |
Orotic acid | inhibition of isozyme hCA I; inhibition of isozyme hCA II | Homo sapiens | |
phenol | inhibition of isozyme hCA I; inhibition of isozyme hCA II | Homo sapiens | |
resorcinol | inhibition of isozyme hCA II | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | required, metalloenzyme | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
H2CO3 | Homo sapiens | - |
CO2 + H2O | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00915 | - |
- |
Homo sapiens | P00918 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
H2CO3 | - |
Homo sapiens | CO2 + H2O | - |
r |
Synonyms | Comment | Organism |
---|---|---|
hCA I | - |
Homo sapiens |
HCA II | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000085 | - |
6-amino-1,3-dimethyluracil | pH 7.4, temperature not specified in the publication | Homo sapiens | |
0.0001035 | - |
5,6-diamino-1,3-dimethyluracil | pH 7.4, temperature not specified in the publication | Homo sapiens | |
0.0001715 | - |
6-amino-1,3-dimethyluracil | pH 7.4, temperature not specified in the publication | Homo sapiens | |
0.000236 | - |
5,6-diamino-1,3-dimethyluracil | pH 7.4, temperature not specified in the publication | Homo sapiens | |
0.0004585 | - |
Isoorotic acid | pH 7.4, temperature not specified in the publication | Homo sapiens | |
0.0007325 | - |
Orotic acid | pH 7.4, temperature not specified in the publication | Homo sapiens | |
0.0055 | - |
phenol | pH 7.4, temperature not specified in the publication | Homo sapiens | |
0.0077 | - |
resorcinol | pH 7.4, temperature not specified in the publication | Homo sapiens | |
0.0099 | - |
catechol | pH 7.4, temperature not specified in the publication | Homo sapiens | |
0.0102 | - |
phenol | pH 7.4, temperature not specified in the publication | Homo sapiens | |
0.01083 | - |
5-bromo-1-(4-methylbenzene-1-sulfonyl)pyrimidine-2,4(1H,3H)-dione | pH 7.4, temperature not specified in the publication | Homo sapiens | |
0.02888 | - |
5-bromo-1-(4-methylbenzene-1-sulfonyl)pyrimidine-2,4(1H,3H)-dione | pH 7.4, temperature not specified in the publication | Homo sapiens | |
0.04951 | - |
5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione | pH 7.4, temperature not specified in the publication | Homo sapiens | |
0.05776 | - |
6-methylpyrimidine-2,4(1H,3H)-dione | pH 7.4, temperature not specified in the publication | Homo sapiens | |
0.1664 | - |
1,3-dimethylpyrimidine-2,4(1H,3H)-dione | pH 7.4, temperature not specified in the publication | Homo sapiens | |
0.3162 | - |
1,3-dimethylpyrimidine-2,4(1H,3H)-dione | pH 7.4, temperature not specified in the publication | Homo sapiens | |
0.428 | - |
5-bromo-1-(methanesulfonyl)pyrimidine-2,4(1H,3H)-dione | pH 7.4, temperature not specified in the publication | Homo sapiens | |
0.645 | - |
5-bromo-1-(methanesulfonyl)pyrimidine-2,4(1H,3H)-dione | pH 7.4, temperature not specified in the publication | Homo sapiens | |
0.795 | - |
benzene-1,3-diol | pH 7.4, temperature not specified in the publication | Homo sapiens | |
1.432 | - |
Isoorotic acid | pH 7.4, temperature not specified in the publication | Homo sapiens | |
1.682 | - |
Orotic acid | pH 7.4, temperature not specified in the publication | Homo sapiens | |
4.003 | - |
benzene-1,2-diol | pH 7.4, temperature not specified in the publication | Homo sapiens |