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Literature summary for 4.2.1.1 extracted from

  • Feng, H.Z.; Jin, J.P.
    Carbonic anhydrase III is expressed in mouse skeletal muscles independent of fiber type-specific myofilament protein isoforms and plays a role in fatigue resistance (2016), Front. Physiol., 7, 597 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.1.1

Protein Variants

Protein Variants Comment Organism
additional information generation of Car3-knockout mice. Loss of CAIII in soleus and tibialanterior (TA) muscles in Car3-KO mice does not change muscle mass, sarcomere protein isoform contents, and the baseline twitch and tetanic contractility as compared with age-matched wild-type controls. Car3-KO TA muscle shows faster force reduction at the beginning but higher resistance at the end during a fatigue test, followed by slower postfatigue recovery than that of wild-type TA muscle. Superfused Car3-KO soleus muscle also have faster total force reduction during fatigue test than that of wild-type soleus. It shows less elevation of resting tension followed by a better postfatigue recovery under acidotic stress Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
H2CO3 Mus musculus
-
 CO2 + H2O
-
 r
H2CO3 Mus musculus 129SEVE
-
 CO2 + H2O
-
 r

Organism

Organism UniProt Comment Textmining
Mus musculus P16015
-
-
Mus musculus 129SEVE P16015
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-
additional information immunohistochemic analysis using monoclonal antibody against CP3, mAb CP3, detailed overview. No CAIII is detected by CP3 in mouse heart and bladder smooth muscle, or in extensor digitorum longus muscle Mus musculus
-
skeletal muscle tibial anterior musle and soleus muscle, broad expression of CAIII in mouse skeletal muscles. Postnatal downregulation and reexpression of CAIII in adult tibial anterior muscle Mus musculus
-
white adipose tissue
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H2CO3
-
 Mus musculus CO2 + H2O
-
 r
H2CO3
-
 Mus musculus 129SEVE CO2 + H2O
-
 r

Synonyms

Synonyms Comment Organism
CA3
-
 Mus musculus
CAIII
-
 Mus musculus
carbonic anhydrase 3
-
 Mus musculus
carbonic anhydrase III
-
 Mus musculus

General Information

General Information Comment Organism
malfunction loss of CAIII in soleus and tibialanterior (TA) muscles in Car3-KO mice does not change muscle mass, sarcomere protein isoform contents, mitochondrial function, and the baseline twitch and tetanic contractility as compared with age-matched wild-type controls. Car3-KO TA muscle shows faster force reduction at the beginning but higher resistance at the end during a fatigue test, followed by slower postfatigue recovery than that of wild-type TA muscle. Superfused Car3-KO soleus muscle also have faster total force reduction during fatigue test than that of wild-type soleus. It shows less elevation of resting tension followed by a better postfatigue recovery under acidotic stress. Car3-KO increases the resistance of soleus muscle to acidosis Mus musculus
physiological function expressing similar fast type of myofilament proteins, CAIII-positive tibial anterior muscle exhibits higher tolerance to fatigue than that of CAIII-negative fast twitch extensor digitorum longus muscle in in situ contractility studies Mus musculus