Literature summary for 4.2.1.1 extracted from

Piazzetta, P.; Marino, T.; Russo, N.
Theoretical investigation on the restoring step of the carbonic anhydrase catalytic cycle for natural and promiscuous substrates (2015), Arch. Biochem. Biophys., 582, 101-106 .

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KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
additional information	-	additional information	kinetic and thermodynamic analysis, molecular modelling, overview	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	required, metalloenzyme, molecular dynamics simulations in catalysis. Active site residues correspond to His94, His96, His119 belonging to the inner coordination shell of the metal ion and Glu106, Thr199, Thr200 belonging to the outer one	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
H2CO3	Homo sapiens	-	CO2 + H2O	-	r

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P00918	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
H2CO3 = CO2 + H2O	reaction mechanism, analysis of the restoring step of the carbonic anhydrase catalytic cycle for natural and promiscuous substrates, natural HCO3-x02and promiscuous H2NCOHN- products, catalytic reaction mechanism, NPT molecular dynamics simulations, overview	Homo sapiens	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
H2CO3	-	Homo sapiens	CO2 + H2O	-	r

Synonyms

Synonyms	Comment	Organism
hCAII	-	Homo sapiens

General Information

General Information	Comment	Organism
additional information	enzyme structure, catalytic mechanism, and molecular dynamics simulations	Homo sapiens

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Release 2023.1 (January 2023)