BRENDA - Enzyme Database show
show all sequences of 4.2.1.1

Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Leishmania donovani chagasi, the protozoan parasite responsible for leishmaniasis

Syrjaenen, L.; Vermelho, A.B.; Rodrigues, I.d.e..A.; Corte-Real, S.; Salonen, T.; Pan, P.; Vullo, D.; Parkkila, S.; Capasso, C.; Supuran, C.T.; J. Med. Chem. 56, 7372-7381 (2013)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
using the baculovirus expression system as a His-tagged fusion protein
Leishmania chagasi
Inhibitors
Inhibitors
Commentary
Organism
Structure
(2Z)-2-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Leishmania chagasi
(2Z)-2-(3-bromobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Leishmania chagasi
(2Z)-2-(3-methoxybenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Leishmania chagasi
(2Z)-2-(4-chlorobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Leishmania chagasi
(2Z)-2-(4-fluorobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Leishmania chagasi
(2Z)-2-(4-methylpentan-2-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Leishmania chagasi
(2Z)-2-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Leishmania chagasi
(2Z)-2-benzylidene-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Leishmania chagasi
(4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
-
Leishmania chagasi
(4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
Leishmania chagasi
1,2-benzothiazol-3(2H)-one 1,1-dioxide
-
Leishmania chagasi
1-(1,2-benzoxazol-3-yl)methanesulfonamide
-
Leishmania chagasi
2-(hydroxymethyl)-4-nitro-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
-
Leishmania chagasi
2-methoxy-N-[(1-methylpyrrolidin-2-yl)methyl]-5-sulfamoylbenzamide
-
Leishmania chagasi
3,5-dichloro-2-hydroxybenzenesulfonamide
-
Leishmania chagasi
3-aminobenzenesulfonamide
-
Leishmania chagasi
4,5-dichlorobenzene-1,3-disulfonamide
-
Leishmania chagasi
4-(1,1-dioxido-1,2-thiazinan-2-yl)benzenesulfonamide
-
Leishmania chagasi
4-(2-aminoethyl)benzenesulfonamide
-
Leishmania chagasi
4-(2-hydroxyethyl)benzenesulfonamide
-
Leishmania chagasi
4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide
-
Leishmania chagasi
4-(aminomethyl)benzenesulfonamide
-
Leishmania chagasi
4-(hydroxymethyl)benzenesulfonamide
-
Leishmania chagasi
4-amino-3-bromobenzenesulfonamide
-
Leishmania chagasi
4-amino-3-chlorobenzenesulfonamide
-
Leishmania chagasi
4-amino-3-fluorobenzenesulfonamide
-
Leishmania chagasi
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
-
Leishmania chagasi
4-amino-6-chlorobenzene-1,3-disulfonamide
-
Leishmania chagasi
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
-
Leishmania chagasi
4-amino-N-(4-sulfamoylphenyl)benzenesulfonamide
-
Leishmania chagasi
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
-
Leishmania chagasi
4-Aminobenzenesulfonamide
-
Leishmania chagasi
4-hydroxybenzenesulfonamide
-
Leishmania chagasi
4-sulfamoylbenzoic acid
-
Leishmania chagasi
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
-
Leishmania chagasi
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
-
Leishmania chagasi
5-([(4-aminophenyl)sulfonyl]amino)-1,3,4-thiadiazole-2-sulfonamide
-
Leishmania chagasi
5-amino-1,3,4-thiadiazole-2-sulfonamide
-
Leishmania chagasi
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
Leishmania chagasi
5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
Leishmania chagasi
6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
-
Leishmania chagasi
6-ethoxy-1,3-benzothiazole-2-sulfonamide
-
Leishmania chagasi
acetazolamide
-
Leishmania chagasi
benzene-1,3-disulfonamide
-
Leishmania chagasi
benzenesulfonamide
-
Leishmania chagasi
N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
-
Leishmania chagasi
N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
-
Leishmania chagasi
N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Leishmania chagasi
N-[(2E)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
-
Leishmania chagasi
[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate
-
Leishmania chagasi
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0158
-
CO2
pH 7.5, 20C
Leishmania chagasi
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
35000
-
SDS-PAGE
Leishmania chagasi
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Leishmania chagasi
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
CO2 + H2O
-
730164
Leishmania chagasi
H2CO3
-
-
-
?
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
935000
-
CO2
pH 7.5, 20C
Leishmania chagasi
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.0000134
-
(2Z)-2-(3-bromobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20C
Leishmania chagasi
0.0000184
-
(2Z)-2-(4-chlorobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20C
Leishmania chagasi
0.0000195
-
(2Z)-2-(4-methylpentan-2-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20C
Leishmania chagasi
0.0000279
-
(2Z)-2-benzylidene-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20C
Leishmania chagasi
0.0000331
-
(2Z)-2-(4-fluorobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20C
Leishmania chagasi
0.0000401
-
(2Z)-2-(3-methoxybenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20C
Leishmania chagasi
0.0000502
-
2-(hydroxymethyl)-4-nitro-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.0000502
-
6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
pH 7.5, 20C
Leishmania chagasi
0.0000515
-
6-ethoxy-1,3-benzothiazole-2-sulfonamide
pH 7.5, 20C
Leishmania chagasi
0.0000596
-
4-sulfamoylbenzoic acid
pH 7.5, 20C
Leishmania chagasi
0.0000734
-
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.000074
-
N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20C
Leishmania chagasi
0.0000871
-
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.0000871
-
N-[(2E)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
pH 7.5, 20C
Leishmania chagasi
0.0000917
-
acetazolamide
pH 7.5, 20C
Leishmania chagasi
0.0000917
-
N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
pH 7.5, 20C
Leishmania chagasi
0.0000951
-
5-([(4-aminophenyl)sulfonyl]amino)-1,3,4-thiadiazole-2-sulfonamide
pH 7.5, 20C
Leishmania chagasi
0.0000953
-
(2Z)-2-(4-chlorobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20C
Leishmania chagasi
0.000136
-
4-amino-N-(4-sulfamoylphenyl)benzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.000144
-
(2Z)-2-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20C
Leishmania chagasi
0.000152
-
(2Z)-2-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20C
Leishmania chagasi
0.000189
-
4,5-dichlorobenzene-1,3-disulfonamide
pH 7.5, 20C
Leishmania chagasi
0.000227
-
4-(2-hydroxyethyl)benzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.000236
-
5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
pH 7.5, 20C
Leishmania chagasi
0.000316
-
N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
pH 7.5, 20C
Leishmania chagasi
0.000338
-
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.000389
-
4-(hydroxymethyl)benzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.000433
-
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
pH 7.5, 20C
Leishmania chagasi
0.000584
-
5-amino-1,3,4-thiadiazole-2-sulfonamide
pH 7.5, 20C
Leishmania chagasi
0.000705
-
4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.000764
-
(4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
pH 7.5, 20C
Leishmania chagasi
0.000806
-
(4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
pH 7.5, 20C
Leishmania chagasi
0.000834
-
4-(1,1-dioxido-1,2-thiazinan-2-yl)benzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.000927
-
4-hydroxybenzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.004819
-
4-amino-6-chlorobenzene-1,3-disulfonamide
pH 7.5, 20C
Leishmania chagasi
0.00596
-
3-aminobenzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.00842
-
4-amino-3-bromobenzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.00891
-
benzene-1,3-disulfonamide
pH 7.5, 20C
Leishmania chagasi
0.009058
-
4-amino-3-chlorobenzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.009083
-
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
pH 7.5, 20C
Leishmania chagasi
0.009135
-
3,5-dichloro-2-hydroxybenzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.009251
-
4-Aminobenzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.0156
-
4-amino-3-fluorobenzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.1
-
1-(1,2-benzoxazol-3-yl)methanesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.1
-
1,2-benzothiazol-3(2H)-one 1,1-dioxide
pH 7.5, 20C
Leishmania chagasi
0.1
-
2-methoxy-N-[(1-methylpyrrolidin-2-yl)methyl]-5-sulfamoylbenzamide
pH 7.5, 20C
Leishmania chagasi
0.1
-
[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate
pH 7.5, 20C
Leishmania chagasi
0.1
-
4-(2-aminoethyl)benzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.1
-
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.1
-
4-(aminomethyl)benzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.1
-
benzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
Cloned(Commentary) (protein specific)
Commentary
Organism
using the baculovirus expression system as a His-tagged fusion protein
Leishmania chagasi
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
(2Z)-2-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Leishmania chagasi
(2Z)-2-(3-bromobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Leishmania chagasi
(2Z)-2-(3-methoxybenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Leishmania chagasi
(2Z)-2-(4-chlorobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Leishmania chagasi
(2Z)-2-(4-fluorobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Leishmania chagasi
(2Z)-2-(4-methylpentan-2-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Leishmania chagasi
(2Z)-2-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Leishmania chagasi
(2Z)-2-benzylidene-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Leishmania chagasi
(4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
-
Leishmania chagasi
(4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
Leishmania chagasi
1,2-benzothiazol-3(2H)-one 1,1-dioxide
-
Leishmania chagasi
1-(1,2-benzoxazol-3-yl)methanesulfonamide
-
Leishmania chagasi
2-(hydroxymethyl)-4-nitro-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
-
Leishmania chagasi
2-methoxy-N-[(1-methylpyrrolidin-2-yl)methyl]-5-sulfamoylbenzamide
-
Leishmania chagasi
3,5-dichloro-2-hydroxybenzenesulfonamide
-
Leishmania chagasi
3-aminobenzenesulfonamide
-
Leishmania chagasi
4,5-dichlorobenzene-1,3-disulfonamide
-
Leishmania chagasi
4-(1,1-dioxido-1,2-thiazinan-2-yl)benzenesulfonamide
-
Leishmania chagasi
4-(2-aminoethyl)benzenesulfonamide
-
Leishmania chagasi
4-(2-hydroxyethyl)benzenesulfonamide
-
Leishmania chagasi
4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide
-
Leishmania chagasi
4-(aminomethyl)benzenesulfonamide
-
Leishmania chagasi
4-(hydroxymethyl)benzenesulfonamide
-
Leishmania chagasi
4-amino-3-bromobenzenesulfonamide
-
Leishmania chagasi
4-amino-3-chlorobenzenesulfonamide
-
Leishmania chagasi
4-amino-3-fluorobenzenesulfonamide
-
Leishmania chagasi
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
-
Leishmania chagasi
4-amino-6-chlorobenzene-1,3-disulfonamide
-
Leishmania chagasi
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
-
Leishmania chagasi
4-amino-N-(4-sulfamoylphenyl)benzenesulfonamide
-
Leishmania chagasi
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
-
Leishmania chagasi
4-Aminobenzenesulfonamide
-
Leishmania chagasi
4-hydroxybenzenesulfonamide
-
Leishmania chagasi
4-sulfamoylbenzoic acid
-
Leishmania chagasi
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
-
Leishmania chagasi
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
-
Leishmania chagasi
5-([(4-aminophenyl)sulfonyl]amino)-1,3,4-thiadiazole-2-sulfonamide
-
Leishmania chagasi
5-amino-1,3,4-thiadiazole-2-sulfonamide
-
Leishmania chagasi
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
Leishmania chagasi
5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
Leishmania chagasi
6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
-
Leishmania chagasi
6-ethoxy-1,3-benzothiazole-2-sulfonamide
-
Leishmania chagasi
acetazolamide
-
Leishmania chagasi
benzene-1,3-disulfonamide
-
Leishmania chagasi
benzenesulfonamide
-
Leishmania chagasi
N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
-
Leishmania chagasi
N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
-
Leishmania chagasi
N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Leishmania chagasi
N-[(2E)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
-
Leishmania chagasi
[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate
-
Leishmania chagasi
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.0000134
-
(2Z)-2-(3-bromobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20C
Leishmania chagasi
0.0000184
-
(2Z)-2-(4-chlorobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20C
Leishmania chagasi
0.0000195
-
(2Z)-2-(4-methylpentan-2-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20C
Leishmania chagasi
0.0000279
-
(2Z)-2-benzylidene-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20C
Leishmania chagasi
0.0000331
-
(2Z)-2-(4-fluorobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20C
Leishmania chagasi
0.0000401
-
(2Z)-2-(3-methoxybenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20C
Leishmania chagasi
0.0000502
-
2-(hydroxymethyl)-4-nitro-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.0000502
-
6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
pH 7.5, 20C
Leishmania chagasi
0.0000515
-
6-ethoxy-1,3-benzothiazole-2-sulfonamide
pH 7.5, 20C
Leishmania chagasi
0.0000596
-
4-sulfamoylbenzoic acid
pH 7.5, 20C
Leishmania chagasi
0.0000734
-
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.000074
-
N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20C
Leishmania chagasi
0.0000871
-
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.0000871
-
N-[(2E)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
pH 7.5, 20C
Leishmania chagasi
0.0000917
-
acetazolamide
pH 7.5, 20C
Leishmania chagasi
0.0000917
-
N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
pH 7.5, 20C
Leishmania chagasi
0.0000951
-
5-([(4-aminophenyl)sulfonyl]amino)-1,3,4-thiadiazole-2-sulfonamide
pH 7.5, 20C
Leishmania chagasi
0.0000953
-
(2Z)-2-(4-chlorobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20C
Leishmania chagasi
0.000136
-
4-amino-N-(4-sulfamoylphenyl)benzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.000144
-
(2Z)-2-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20C
Leishmania chagasi
0.000152
-
(2Z)-2-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20C
Leishmania chagasi
0.000189
-
4,5-dichlorobenzene-1,3-disulfonamide
pH 7.5, 20C
Leishmania chagasi
0.000227
-
4-(2-hydroxyethyl)benzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.000236
-
5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
pH 7.5, 20C
Leishmania chagasi
0.000316
-
N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
pH 7.5, 20C
Leishmania chagasi
0.000338
-
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.000389
-
4-(hydroxymethyl)benzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.000433
-
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
pH 7.5, 20C
Leishmania chagasi
0.000584
-
5-amino-1,3,4-thiadiazole-2-sulfonamide
pH 7.5, 20C
Leishmania chagasi
0.000705
-
4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.000764
-
(4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
pH 7.5, 20C
Leishmania chagasi
0.000806
-
(4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
pH 7.5, 20C
Leishmania chagasi
0.000834
-
4-(1,1-dioxido-1,2-thiazinan-2-yl)benzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.000927
-
4-hydroxybenzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.004819
-
4-amino-6-chlorobenzene-1,3-disulfonamide
pH 7.5, 20C
Leishmania chagasi
0.00596
-
3-aminobenzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.00842
-
4-amino-3-bromobenzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.00891
-
benzene-1,3-disulfonamide
pH 7.5, 20C
Leishmania chagasi
0.009058
-
4-amino-3-chlorobenzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.009083
-
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
pH 7.5, 20C
Leishmania chagasi
0.009135
-
3,5-dichloro-2-hydroxybenzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.009251
-
4-Aminobenzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.0156
-
4-amino-3-fluorobenzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.1
-
1-(1,2-benzoxazol-3-yl)methanesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.1
-
1,2-benzothiazol-3(2H)-one 1,1-dioxide
pH 7.5, 20C
Leishmania chagasi
0.1
-
2-methoxy-N-[(1-methylpyrrolidin-2-yl)methyl]-5-sulfamoylbenzamide
pH 7.5, 20C
Leishmania chagasi
0.1
-
[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate
pH 7.5, 20C
Leishmania chagasi
0.1
-
4-(2-aminoethyl)benzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.1
-
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.1
-
4-(aminomethyl)benzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
0.1
-
benzenesulfonamide
pH 7.5, 20C
Leishmania chagasi
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0158
-
CO2
pH 7.5, 20C
Leishmania chagasi
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
35000
-
SDS-PAGE
Leishmania chagasi
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
CO2 + H2O
-
730164
Leishmania chagasi
H2CO3
-
-
-
?
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
935000
-
CO2
pH 7.5, 20C
Leishmania chagasi
KCat/KM [mM/s]
kcat/KM Value [1/mMs-1]
kcat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
59000
-
CO2
pH 7.5, 20C
Leishmania chagasi
KCat/KM [mM/s] (protein specific)
KCat/KM Value [1/mMs-1]
KCat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
59000
-
CO2
pH 7.5, 20C
Leishmania chagasi
Other publictions for EC 4.2.1.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
746925
Koruza
Deuteration of human carbonic ...
Homo sapiens
Arch. Biochem. Biophys.
645
26-33
2018
-
-
1
1
1
-
1
1
-
1
-
2
-
3
-
-
1
-
-
1
-
-
4
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
2
2
-
-
2
-
2
-
2
-
2
-
-
-
2
-
1
-
-
4
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
747013
Peirce
Kinetic characterization of c ...
Caminibacter sp.
Biochem. Eng. J.
138
1-11
2018
-
1
-
-
1
-
-
1
-
1
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
747489
Langella
Biochemical, biophysical and ...
Homo sapiens
Cell. Mol. Life Sci.
75
3283-3296
2018
1
-
1
-
-
-
-
1
1
1
1
1
-
2
-
-
1
-
-
1
-
-
1
2
1
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
1
1
1
1
-
-
-
1
-
1
-
-
1
2
1
-
-
-
1
-
-
-
-
2
2
-
-
-
747699
Chiaramonte
2-Benzylpiperazine a new scaf ...
Homo sapiens
Eur. J. Med. Chem.
151
363-375
2018
-
-
-
1
-
-
40
-
-
-
-
4
-
6
-
-
-
-
-
-
-
-
8
-
1
-
-
-
1
-
-
-
135
-
-
-
-
-
-
1
-
-
-
143
137
-
-
-
-
4
-
-
-
-
-
-
-
-
8
-
4
-
-
-
4
-
-
-
-
1
1
-
-
-
747863
Koh
Molecular characterization of ...
Tridacna squamosa
Front. Physiol.
9
281
2018
-
-
1
-
-
-
-
-
2
1
-
1
-
4
-
-
-
-
-
6
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
1
-
1
-
-
-
-
-
6
-
-
1
1
-
-
-
-
-
-
-
-
1
2
2
1
-
-
747901
Sumi
Molecular cloning and charact ...
Takifugu rubripes
Gene
640
57-65
2018
-
-
1
-
-
-
-
-
1
1
-
1
-
7
-
2
-
-
-
2
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
-
1
-
-
2
-
-
2
-
-
1
1
-
-
-
-
-
-
-
-
-
3
3
-
-
-
748135
Kocyigit
Characterization and inhibiti ...
Ovis aries, Ovis aries Kangal Akkaraman
J. Biochem. Mol. Toxicol.
32
e22172
2018
-
-
-
-
-
-
6
1
-
1
-
2
-
5
-
-
1
-
-
3
1
-
4
1
1
1
-
-
1
1
-
-
6
-
6
-
-
-
-
-
-
-
6
6
6
1
-
1
-
2
-
-
-
1
-
3
1
-
4
1
1
1
-
-
1
1
-
-
-
-
-
-
-
-
748317
Bouchouit
Synthesis, X-ray structure, i ...
Homo sapiens
J. Enzyme Inhib. Med. Chem.
33
1150-1159
2018
-
-
-
-
-
-
5
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
7
-
-
-
-
-
-
-
8
10
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
748692
Bhatt
Crystal structure of carbonic ...
Homo sapiens
Mol. Neurobiol.
55
7431-7437
2018
6
-
1
1
-
-
28
-
-
1
-
1
-
3
-
-
1
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
6
-
8
6
-
1
-
1
-
-
8
28
6
-
-
1
-
1
-
-
-
1
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
747248
Iqbal
Carbohydrazones as new class ...
Bos taurus
Bioorg. Chem.
72
89-101
2017
-
1
-
-
-
-
11
-
-
1
-
1
-
1
-
-
-
-
-
1
-
-
2
-
1
-
-
-
1
-
-
-
-
-
1
-
1
-
-
-
-
-
1
11
-
-
-
1
-
1
-
-
-
-
-
1
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
747292
Jun
Expression and characterizati ...
Aliivibrio salmonicida
Bioprocess Biosyst. Eng.
40
413-421
2017
-
1
1
-
1
-
5
-
-
1
-
1
-
3
-
-
1
-
-
-
-
-
2
1
2
1
1
-
1
1
4
-
-
-
-
-
1
1
-
-
1
-
-
5
-
-
-
1
-
1
-
-
-
1
-
-
-
-
2
1
2
1
1
-
1
1
4
-
-
-
-
-
-
-
747545
Bhatt
Structure-activity relationsh ...
Homo sapiens
ChemBioChem
18
213-222
2017
-
-
1
1
2
-
6
-
3
1
-
4
-
4
-
-
1
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
20
-
-
-
-
2
-
2
2
-
-
24
20
-
6
4
-
4
-
-
-
2
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
747900
Wang
Identification, structural ch ...
Hyriopsis cumingii
Gene
636
78-86
2017
-
-
1
-
-
-
-
-
-
1
-
1
-
2
-
2
-
-
-
3
-
-
1
1
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
1
-
-
2
-
-
3
-
-
1
1
-
-
-
-
-
-
-
1
-
2
2
-
-
-
747960
Wahiduzzaman
Characterization of folding i ...
Homo sapiens
Int. J. Biol. Macromol.
95
881-887
2017
-
-
1
-
-
-
-
-
-
1
-
1
-
2
-
-
1
-
-
-
-
-
1
2
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
1
2
1
-
-
-
1
-
-
-
-
-
-
-
-
-
748133
Huyut
Inhibition properties of some ...
Homo sapiens
J. Biochem. Mol. Toxicol.
31
e21930
2017
-
-
-
-
-
-
6
-
-
1
-
2
-
3
-
-
1
-
-
2
-
-
4
-
1
-
-
-
1
-
-
-
-
-
10
-
-
-
-
-
-
-
10
12
-
-
-
2
-
2
-
-
-
2
-
3
-
-
4
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
748134
Kocyigit
Inhibitory effects of some dr ...
Ovis aries, Ovis aries Kangal Akkaraman
J. Biochem. Mol. Toxicol.
32
e22000
2017
-
-
-
-
-
-
10
-
-
1
-
2
-
5
-
-
1
-
-
2
1
-
4
-
-
-
-
-
-
-
-
-
-
-
10
-
-
-
-
-
-
-
10
10
-
-
-
1
-
2
-
-
-
1
-
2
1
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
748312
Perfetto
Cloning, expression and purif ...
Mytilus galloprovincialis
J. Enzyme Inhib. Med. Chem.
32
1029-1035
2017
-
-
1
-
-
-
1
1
-
1
-
1
-
4
-
-
-
-
-
1
-
-
1
2
1
-
-
2
1
-
-
-
2
-
-
-
-
1
-
-
-
-
-
1
2
1
-
1
-
1
-
-
-
-
-
1
-
-
1
2
1
-
-
2
1
-
-
-
-
2
2
-
2
2
748314
Soydan
Carbonic anhydrase from Apis ...
Apis mellifera
J. Enzyme Inhib. Med. Chem.
32
47-50
2017
-
-
-
-
-
-
6
-
-
1
-
1
-
2
-
-
1
-
-
1
1
-
3
1
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
7
6
-
-
-
1
-
1
-
-
-
1
-
1
1
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
748315
Perfetto
Biochemical characterization ...
Mytilus galloprovincialis
J. Enzyme Inhib. Med. Chem.
32
632-639
2017
-
-
-
-
-
-
1
1
1
1
1
1
-
5
-
-
1
-
-
1
-
-
2
2
1
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
1
1
1
1
1
-
-
-
1
-
1
-
-
2
2
1
-
-
-
1
-
-
-
-
2
2
-
-
-
748316
Alper Tuerkoglu
Carbonic anhydrase inhibitory ...
Homo sapiens
J. Enzyme Inhib. Med. Chem.
32
74-77
2017
-
-
-
-
-
-
19
-
-
1
-
2
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
22
-
-
-
-
-
-
-
-
-
-
35
22
-
-
2
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
748840
Patrikainen
Identification and characteri ...
Danio rerio
PeerJ
5
e4128
2017
-
-
1
-
1
-
1
1
-
1
1
1
-
3
-
1
1
-
-
14
-
-
1
1
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
-
1
-
-
1
1
1
-
1
1
1
-
-
1
1
-
14
-
-
1
1
-
-
-
1
-
-
-
-
-
2
2
-
1
1
748873
Ip
Carbonic anhydrase 2-like in ...
Tridacna squamosa
Physiol. Rep.
5
e13494
2017
-
-
1
-
-
-
-
-
1
1
-
1
-
1
-
-
-
-
-
3
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
-
1
-
-
-
-
-
3
-
-
1
1
-
-
-
-
-
-
-
-
1
2
2
1
-
-
749204
Al-Dhrub
-
Immobilization and characteri ...
Homo sapiens
Process Biochem.
57
95-104
2017
-
1
-
-
1
-
-
1
-
1
-
1
-
1
-
-
1
-
-
-
-
1
2
-
1
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
1
-
1
-
-
-
1
-
-
-
1
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
746566
Idrees
Cloning, expression, purifica ...
Homo sapiens
3 Biotech
6
16
2016
-
-
1
-
-
-
-
-
2
-
-
1
-
2
-
-
1
-
1
-
-
-
2
2
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
1
1
-
-
-
2
2
1
-
-
-
1
-
-
-
-
1
1
-
-
-
746943
Bian
Temperature stability of poly ...
Homo sapiens
Artif. Cells Nanomed. Biotechnol.
44
41-47
2016
-
-
-
-
1
1
-
-
-
-
-
1
-
5
-
-
-
-
-
1
-
-
2
-
1
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
1
-
1
-
1
-
-
-
-
1
1
-
-
-
747029
McGurn
The structure, kinetics and i ...
Synechocystis sp. PCC 6803, Synechocystis sp. PCC 6803 / Kazusa
Biochem. J.
473
4559-4572
2016
-
-
2
1
-
-
1
2
4
2
-
2
-
5
-
-
2
-
-
-
-
-
5
2
2
-
-
3
1
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
2
4
2
-
2
-
-
-
2
-
-
-
-
5
2
2
-
-
3
1
-
-
-
-
4
4
-
2
2
747258
De Luca
Cloning, characterization and ...
Colwellia psychrerythraea, Colwellia psychrerythraea 34H / ATCC BAA-681
Bioorg. Med. Chem.
24
835-840
2016
-
-
1
-
-
-
34
1
-
1
1
6
-
5
-
-
1
-
-
-
-
-
6
2
1
-
-
1
1
-
-
-
33
-
-
-
-
1
-
-
-
-
-
34
33
1
-
1
1
6
-
-
-
1
-
-
-
-
6
2
1
-
-
1
1
-
-
-
-
-
-
-
-
-
747276
Del Prete
Cloning, expression, purifica ...
Plasmodium falciparum
Bioorg. Med. Chem. Lett.
26
4184-4190
2016
-
-
1
-
1
-
41
-
-
2
-
1
-
3
-
-
-
-
-
-
-
-
2
-
1
-
-
2
1
-
-
-
78
-
-
-
-
1
-
-
1
-
-
41
78
-
-
2
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
2
1
-
-
-
-
2
2
-
2
2
747660
Faridi
Novel alkalistable alpha-carb ...
Bacillus halodurans, Bacillus halodurans TSLV1 / MTCC 10961
Environ. Sci. Pollut. Res. Int.
23
15236-15249
2016
-
-
1
-
1
-
5
-
-
3
1
2
-
4
-
1
1
-
-
-
-
-
4
1
1
-
4
-
1
1
2
-
-
-
-
-
-
1
-
-
1
-
-
5
-
-
-
3
1
2
-
-
1
1
-
-
-
-
4
1
1
-
4
-
1
1
2
-
-
1
1
-
-
-
747662
Kucuk
Purification and characteriza ...
Salmo trutta Labrax Coruhensis
Environ. Toxicol. Pharmacol.
44
134-139
2016
-
-
-
-
-
-
5
2
-
1
-
1
-
2
-
-
1
-
-
3
1
-
2
1
1
-
-
1
1
1
1
-
5
-
5
-
-
-
-
-
-
-
5
5
5
2
-
1
-
1
-
-
-
1
-
3
1
-
2
1
1
-
-
1
1
1
1
-
-
1
1
-
1
1
747862
Feng
Carbonic anhydrase III is exp ...
Mus musculus 129SEVE, Mus musculus
Front. Physiol.
7
597
2016
-
-
-
-
1
-
-
-
1
-
-
2
-
4
-
-
-
-
-
6
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
6
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
747955
Faridi
Characteristics of recombinan ...
Bacillus halodurans, Bacillus halodurans TSLV1
Int. J. Biol. Macromol.
89
659-668
2016
-
1
1
-
-
-
26
-
-
4
1
4
-
4
-
-
1
-
-
-
-
-
6
2
1
-
1
-
1
-
1
-
-
-
-
-
1
1
-
-
-
-
-
26
-
-
-
4
1
4
-
-
-
1
-
-
-
-
6
2
1
-
1
-
1
-
1
-
-
2
2
-
-
-
748270
Juozapaitiene
Purification, enzymatic activ ...
Homo sapiens
J. Biotechnol.
240
31-42
2016
-
1
1
-
-
-
9
1
1
1
-
2
-
3
-
1
1
-
-
14
-
-
3
2
1
-
-
-
1
-
-
-
1
-
-
-
1
1
-
-
-
-
-
9
1
1
1
1
-
2
-
-
1
1
-
14
-
-
3
2
1
-
-
-
1
-
-
-
-
-
-
-
-
-
748305
Eminoglu
Cloning, expression and bioch ...
Enterobacter sp. B13
J. Enzyme Inhib. Med. Chem.
31
1111-1118
2016
-
-
1
-
-
-
1
1
-
1
-
1
-
4
-
-
1
-
-
-
-
-
3
1
1
-
-
1
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
1
1
-
1
-
1
-
-
-
1
-
-
-
-
3
1
1
-
-
1
1
-
-
-
-
1
1
-
1
1
748306
Orhan
Interaction of anions with a ...
Halomonas sp.
J. Enzyme Inhib. Med. Chem.
31
1119-1123
2016
-
-
-
-
-
-
11
-
-
2
-
1
-
4
-
-
1
-
-
-
1
-
3
-
1
-
-
-
1
-
-
-
10
-
-
-
-
-
-
-
-
-
-
11
10
-
-
2
-
1
-
-
-
1
-
-
1
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
748307
Durdagi
Kinetic and docking studies o ...
Homo sapiens
J. Enzyme Inhib. Med. Chem.
31
1214-1220
2016
-
-
1
-
-
-
18
-
-
1
-
3
-
4
-
-
1
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
38
-
-
-
-
1
-
-
-
-
-
50
38
-
-
3
-
3
-
-
-
3
-
3
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
748308
Kuecuekbay
Synthesis, characterization a ...
Homo sapiens
J. Enzyme Inhib. Med. Chem.
31
1221-1225
2016
-
-
-
-
-
-
15
-
1
1
-
4
-
5
-
-
-
-
-
-
-
-
4
-
1
-
-
-
1
-
-
-
22
-
-
-
-
-
-
-
-
-
-
25
25
-
4
4
-
4
-
-
-
-
-
-
-
-
4
-
4
-
-
-
4
-
-
-
-
-
-
-
-
-
748311
Del Prete
Cloning, expression and purif ...
Plasmodium falciparum
J. Enzyme Inhib. Med. Chem.
31
54-59
2016
-
1
1
-
1
-
1
-
-
1
-
1
-
2
-
-
-
-
-
1
-
-
1
1
1
-
-
2
1
-
-
-
2
-
-
-
1
1
-
-
1
-
-
1
2
-
-
1
-
1
-
-
-
-
-
1
-
-
1
1
1
-
-
2
1
-
-
-
-
2
2
-
2
2
748524
Karakostis
Characterization of an alpha ...
Paracentrotus lividus
Mar. Biotechnol.
18
384-395
2016
-
-
1
-
-
-
-
-
-
1
-
1
-
8
-
1
1
-
-
3
-
-
2
2
-
-
-
-
1
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
1
-
-
1
1
-
3
-
-
2
2
-
-
-
-
1
-
-
1
-
2
2
-
-
-
748811
Cau
Mycobacterial carbonic anhydr ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618, Mycobacterium tuberculosis H37Rv
Org. Biomol. Chem.
14
8322-8330
2016
-
-
-
-
-
-
12
-
-
1
-
3
-
5
-
-
-
-
-
-
-
-
6
1
1
-
-
-
1
-
-
-
33
-
-
-
-
-
-
-
-
-
-
12
33
-
-
1
-
3
-
-
-
-
-
-
-
-
6
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
748857
Karacan
Characterization of nineteen ...
Bos taurus, Pisum sativum
Photosyn. Res.
130
167-182
2016
-
-
-
-
-
-
28
-
1
2
-
2
-
2
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
28
-
-
1
2
-
2
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
746623
Diaz-Torres
Structural and biophysical ch ...
Hydrogenovibrio crunogenus, Hydrogenovibrio crunogenus XCL-2
Acta Crystallogr. Sect. D
71
1745-1756
2015
-
-
1
1
-
-
1
1
-
1
1
2
-
4
-
-
1
1
-
-
-
-
2
2
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
1
-
1
1
2
-
-
-
1
-
-
-
-
2
2
-
-
1
-
-
-
-
-
-
1
1
-
-
-
746912
Piazzetta
Theoretical investigation on ...
Homo sapiens
Arch. Biochem. Biophys.
582
101-106
2015
-
-
-
-
-
-
-
1
-
1
-
1
-
2
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
747093
Pinter
Kinetics of zinc and cadmium ...
Bos taurus
Biochemistry
54
6284-6293
2015
-
-
-
-
-
-
-
-
-
1
-
1
-
2
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
747255
De Luca
Cloning, characterization and ...
Pseudoalteromonas haloplanktis ANT/505
Bioorg. Med. Chem.
23
4405-4409
2015
-
-
1
-
-
-
27
-
-
-
-
3
-
3
-
-
1
-
-
-
-
-
3
-
1
-
-
1
1
-
-
-
26
-
-
-
-
1
-
-
-
-
-
27
26
-
-
-
-
3
-
-
-
1
-
-
-
-
3
-
1
-
-
1
1
-
-
-
-
-
-
-
1
1
747269
De Simone
Crystal structure of the most ...
Sulfurihydrogenibium azorense, Sulfurihydrogenibium azorense Az-Fu1 / DSM 15241 / OCM 825
Bioorg. Med. Chem. Lett.
25
2002-2006
2015
-
-
1
1
-
-
1
-
-
1
-
6
-
4
-
-
1
-
-
-
-
-
6
1
1
-
-
1
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
1
-
6
-
-
-
1
-
-
-
-
6
1
1
-
-
1
1
-
-
-
-
1
1
-
1
1
747272
De Luca
Cloning, characterization and ...
Nostoc commune
Bioorg. Med. Chem. Lett.
25
4970-4975
2015
-
-
1
-
-
-
36
-
1
1
-
2
-
3
-
-
-
-
-
-
-
-
4
-
-
-
-
1
-
-
-
-
35
-
-
-
-
1
-
-
-
-
-
36
35
-
1
1
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
1
-
-
-
-
-
2
2
-
1
1
747607
Esbaugh
Characterization of carbonic ...
Python bivittatus
Comp. Biochem. Physiol. B
187
71-77
2015
-
-
1
-
-
-
3
1
1
1
-
1
-
5
-
-
-
-
-
2
-
-
2
-
-
-
-
1
-
-
-
-
4
-
-
-
-
1
-
-
-
-
-
3
4
1
1
1
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
1
-
-
-
-
1
1
1
1
-
-
747974
Di Fiore
Thermostable carbonic anhydra ...
Bos taurus, Caminibacter mediatlanticus, Caminibacter mediatlanticus TB-2, Citrobacter freundii, Desulfovibrio vulgaris, Desulfovibrio vulgaris Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303, Homo sapiens, Methanosarcina thermophila, Methanothermobacter thermautotrophicus, Methanothermobacter thermautotrophicus ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg, Persephonella marina, Persephonella marina DSM 14350 / EX-H1, Pyrococcus horikoshii, Serratia sp. ISTD04, Sulfurihydrogenibium azorense, Sulfurihydrogenibium sp. YO3AOP1, Thermovibrio ammonificans, Thermovibrio ammonificans DSM 15698 / JCM 12110 / HB-1
Int. J. Mol. Sci.
16
15456-15480
2015
-
13
1
5
12
-
1
5
-
16
-
18
-
19
-
-
1
13
-
-
-
-
22
4
7
1
11
9
7
-
-
-
-
-
-
-
13
1
-
5
12
-
-
1
-
5
-
16
-
18
-
-
-
1
-
-
-
-
22
4
7
1
11
9
7
-
-
-
-
13
13
-
9
9
748131
Demirdag
Purification and characteriza ...
Salmo labrax
J. Biochem. Mol. Toxicol.
29
123-128
2015
-
-
-
-
-
-
23
1
-
1
-
2
-
2
-
-
1
-
-
3
1
-
3
1
1
-
-
-
1
-
-
-
10
-
-
-
-
-
-
-
-
-
-
23
10
1
-
1
-
2
-
-
-
1
-
3
1
-
3
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
748304
Del Prete
Biochemical characterization ...
Porphyromonas gingivalis, Porphyromonas gingivalis ATCC 33277
J. Enzyme Inhib. Med. Chem.
30
366-370
2015
-
-
1
-
-
-
1
-
-
1
-
2
-
6
-
-
-
-
-
-
-
-
4
-
1
-
-
1
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
1
-
-
1
-
2
-
-
-
-
-
-
-
-
4
-
1
-
-
1
1
-
-
-
-
-
-
-
1
1
748739
Warden
Rational engineering of a mes ...
Homo sapiens
Nat. Commun.
6
10278
2015
-
-
1
1
6
1
2
-
-
3
-
1
-
1
-
-
1
-
-
-
1
-
2
1
4
-
1
-
1
-
-
-
-
-
1
-
-
1
-
1
6
1
1
2
-
-
-
3
-
1
-
-
-
1
-
-
1
-
2
1
4
-
1
-
1
-
-
-
-
1
1
-
-
-
748948
Soto
Functional characterization o ...
Arabidopsis thaliana
Plant J.
83
831-844
2015
-
-
1
-
1
-
-
-
1
1
-
4
-
9
-
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
4
-
-
-
-
-
4
4
-
4
-
-
-
-
-
8
-
-
4
-
-
-
-
-
-
-
-
-
1
2
8
4
-
-
748973
Benlloch
Crystal structure and functio ...
Chlamydomonas reinhardtii
Plant Physiol.
167
950-962
2015
-
-
1
1
1
-
3
-
3
1
-
1
-
3
-
-
1
-
-
-
-
-
1
2
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
1
-
-
3
-
-
3
1
-
1
-
-
-
1
-
-
-
-
1
2
1
-
-
-
1
-
-
-
-
3
3
-
-
-
728948
Iqbal
A capillary electrophoresis-ba ...
Bos taurus
Anal. Biochem.
444
16-21
2014
-
-
-
-
-
-
1
1
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
729394
Del Prete
Cloning, characterization and ...
Conticribra weissflogii
Bioorg. Med. Chem.
22
531-537
2014
-
-
-
-
-
-
6
-
-
-
1
-
-
7
-
-
1
-
-
-
-
-
1
-
1
-
-
1
1
-
-
-
6
-
-
-
-
-
-
-
-
-
-
6
6
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
1
-
-
1
1
-
-
-
-
-
-
-
1
1
729718
Lehneck
Crystal structures of two tetr ...
Sordaria macrospora
FEBS J.
281
1759-1772
2014
-
-
1
1
-
-
10
-
2
-
2
-
-
5
-
-
-
-
-
-
-
-
2
1
1
-
-
2
-
1
-
-
15
-
-
-
-
2
-
2
-
-
-
19
15
-
2
-
2
-
-
-
-
-
-
-
-
-
2
2
2
-
-
2
-
2
-
-
-
1
2
-
2
2
730553
de Araujo
Identification and characteriz ...
Nostoc sp.
Photosyn. Res.
121
135-150
2014
1
-
1
-
-
-
2
-
2
-
-
-
-
6
-
-
-
-
-
-
-
-
2
-
1
1
1
1
1
1
-
-
-
-
-
1
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
2
-
1
1
1
1
1
1
-
-
-
-
-
-
1
1
748302
Del Prete
Biochemical characterization ...
Conticribra weissflogii
J. Enzyme Inhib. Med. Chem.
29
906-911
2014
-
-
1
-
-
-
-
-
-
1
-
1
-
5
-
-
1
-
-
-
-
-
3
-
1
-
1
1
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
3
-
1
-
1
1
1
-
-
-
-
2
2
-
1
1
748367
Moeker
Structural insights into carb ...
Homo sapiens
J. Med. Chem.
57
8635-8645
2014
-
-
-
-
-
-
12
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
12
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
749198
Kanth
-
Highly thermostable carbonic ...
Persephonella marina, Persephonella marina DSM 14350 / EX-H1
Process Biochem.
49
2114-2121
2014
-
-
1
-
-
-
6
1
-
3
-
2
-
3
-
-
1
-
-
-
-
-
6
1
3
-
1
1
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
6
-
1
-
3
-
2
-
-
-
1
-
-
-
-
6
1
3
-
1
1
2
1
-
-
-
-
-
-
1
1
726812
Zimmerman
Role of Trp19 and Tyr200 in ca ...
Methanosarcina thermophila
Arch. Biochem. Biophys.
529
11-17
2013
-
-
-
1
7
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
1
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
7
-
-
-
-
-
-
-
-
14
14
728868
Boone
Structural and catalytic chara ...
Homo sapiens
Acta Crystallogr. Sect. D
69
1414-1422
2013
-
-
1
1
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
4
-
1
-
-
-
-
-
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
4
-
1
-
-
-
-
-
-
-
2
2
729371
Akdemir
The extremo-alpha-carbonic anh ...
Sulfurihydrogenibium azorense
Bioorg. Med. Chem. Lett.
23
1087-1090
2013
12
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
1
-
-
3
1
-
-
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
3
1
-
-
-
-
-
-
-
-
-
729373
Monti
Kinetic and anion inhibition s ...
Flaveria bidentis
Bioorg. Med. Chem. Lett.
23
1626-1630
2013
-
-
-
-
-
-
11
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
11
-
-
-
-
-
-
-
-
-
-
11
11
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
729374
Del Prete
A highly catalytically active ...
Porphyromonas gingivalis
Bioorg. Med. Chem. Lett.
23
4067-4071
2013
-
-
-
-
-
-
19
-
-
-
1
-
-
6
-
-
1
-
-
-
-
-
1
-
1
-
-
1
1
-
-
-
19
-
-
-
-
-
-
-
-
-
-
19
19
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
1
-
-
1
1
-
-
-
-
-
-
-
1
1
729386
Demirdag
Purification and characterizat ...
Ovis aries
Bioorg. Med. Chem.
21
1522-1525
2013
-
-
-
-
-
-
9
1
-
-
1
-
-
2
-
-
1
-
-
2
-
1
1
-
1
-
-
-
1
-
-
-
9
-
-
-
-
-
-
-
-
-
-
9
9
1
-
-
1
-
-
-
-
1
-
2
-
1
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
729657
Russo
Kinetic study of a novel therm ...
Sulfurihydrogenibium yellowstonense, Sulfurihydrogenibium yellowstonense YO3AOP1
Enzyme Microb. Technol.
53
271-277
2013
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
1
-
2
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
2
1
1
-
-
-
-
-
-
-
-
-
729927
Kumar
Biochemistry and physiology of ...
Clostridium perfringens
J. Bacteriol.
195
2262-2269
2013
-
-
-
-
-
-
-
1
-
1
2
-
-
4
-
-
-
-
-
-
-
-
1
1
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
2
-
-
-
-
-
-
-
-
-
1
1
1
-
-
1
-
-
-
-
-
1
1
-
1
1
730163
Pan
Cloning, characterization, and ...
Malassezia globosa, Trypanosoma cruzi
J. Med. Chem.
56
1761-1771
2013
-
-
2
-
-
-
89
2
-
-
2
-
-
4
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
91
-
-
-
-
2
-
-
-
-
-
89
91
2
-
-
2
-
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
2
2
730164
Syrjaenen
Cloning, characterization, and ...
Leishmania chagasi
J. Med. Chem.
56
7372-7381
2013
-
-
1
-
-
-
50
1
-
-
1
-
-
5
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
51
-
-
-
-
1
-
-
-
-
-
50
51
1
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
730266
Al-Samir
Activity and distribution of i ...
Homo sapiens
J. Physiol.
591
4963-4982
2013
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
730639
Hopkinson
Quantification of extracellula ...
Conticribra weissflogii, Thalassiosira pseudonana
Plant Physiol.
162
1142-1152
2013
-
-
-
-
-
-
4
1
-
-
-
-
-
4
-
-
-
-
-
-
-
-
2
-
-
-
-
2
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
2
2
2
-
-
1
2
2
1
-
-
728989
Kanth
Expression and characterizatio ...
Dunaliella
Appl. Biochem. Biotechnol.
167
2341-2356
2012
-
-
1
-
-
-
-
-
-
10
1
-
-
3
-
-
-
-
-
-
-
-
1
-
2
-
1
-
-
1
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
10
1
-
-
-
-
-
-
-
-
-
1
-
2
-
1
-
-
1
1
-
-
-
-
-
-
-
729102
Tu
Role of zinc in catalytic acti ...
Homo sapiens
Arch. Biochem. Biophys.
521
90-94
2012
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
729224
West
Structural and kinetic effects ...
Homo sapiens
Biochemistry
51
9156-9163
2012
-
-
1
1
3
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
1
-
-
4
1
-
-
-
-
-
-
-
-
1
-
1
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
4
1
-
-
-
-
-
-
-
4
4
729383
Ohradanova
Cloning, characterization and ...
Astrosclera willeyana
Bioorg. Med. Chem.
20
1403-1410
2012
-
-
1
-
-
-
42
1
-
-
1
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
42
-
-
-
-
1
-
-
-
-
-
42
42
1
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
729384
Turkoglu
Mutation of active site residu ...
Homo sapiens
Bioorg. Med. Chem.
20
2208-2213
2012
-
-
-
-
3
-
12
3
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
1
-
-
3
1
-
-
-
12
-
-
-
-
-
-
-
3
-
-
12
12
3
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
3
1
-
-
-
-
-
-
-
4
4
730119
Capasso
Biochemical properties of a no ...
Sulfurihydrogenibium yellowstonense, Sulfurihydrogenibium yellowstonense YO3AO81
J. Enzyme Inhib. Med. Chem.
27
892-897
2012
-
-
1
-
-
-
-
1
-
-
1
-
-
5
-
-
1
-
-
-
-
-
2
-
2
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
1
-
-
-
-
2
-
2
-
1
-
1
-
-
-
-
-
-
-
-
-
730159
Del Prete
DNA cloning, characterization, ...
Vibrio cholerae
J. Med. Chem.
55
10742-10748
2012
-
-
1
-
-
-
40
1
-
-
1
-
-
3
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
40
-
-
-
-
1
-
-
-
-
-
40
40
1
-
-
1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
730860
Fisher
Kinetic and structural charact ...
Homo sapiens
Protein Eng. Des. Sel.
25
347-355
2012
-
-
-
1
6
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
5
5
713684
Nishita
Biochemical and developmental ...
Gallus gallus, Gallus gallus Araucana-chicken
Acta Vet. Scand.
53
16
2011
-
-
-
-
-
-
30
-
-
-
-
-
-
3
-
-
1
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
22
-
-
-
-
-
-
-
22
30
-
-
-
-
-
-
-
-
-
1
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
713954
Mikulski
Kinetic and crystallographic s ...
Homo sapiens
Arch. Biochem. Biophys.
506
181-187
2011
-
-
-
-
9
-
-
-
-
1
-
1
-
2
-
-
-
1
-
-
-
-
2
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
9
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
1
-
-
-
-
-
-
1
1
713967
Hoffmann
Co(II)-substituted Haemophilus ...
Haemophilus influenzae
Arch. Biochem. Biophys.
511
80-87
2011
-
-
1
1
-
-
1
1
-
2
1
1
-
2
-
-
1
-
-
-
-
-
1
2
1
-
-
-
1
1
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
1
-
2
1
1
-
-
-
1
-
-
-
-
1
2
1
-
-
-
1
1
-
-
-
-
-
-
-
-
714344
Li
Role of hypoxia and EGF on exp ...
Homo sapiens
Biochim. Biophys. Acta
1813
159-167
2011
-
-
-
-
-
-
-
-
1
1
-
-
-
1
-
2
-
-
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
2
-
-
2
-
-
-
2
-
-
-
-
-
-
-
-
1
2
2
1
-
-
714353
Tsikou
Characterization of two novel ...
Lotus japonicus, Lotus japonicus Gifu B-129
Biochim. Biophys. Acta
1814
496-504
2011
-
-
1
-
-
-
-
1
-
1
-
-
-
7
-
-
1
-
-
2
-
-
-
2
1
-
-
-
2
-
-
-
-
2
-
-
-
2
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
2
-
4
-
-
-
4
2
-
-
-
4
-
-
2
1
1
2
2
-
-
714439
Rodriguez
N-beta-Glycosyl sulfamides are ...
Homo sapiens
Bioorg. Med. Chem. Lett.
21
4447-4450
2011
-
-
-
-
-
-
14
-
2
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
48
-
-
-
-
-
-
-
-
-
-
14
48
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
714441
Saada
Carbonic anhydrase I and II ac ...
Homo sapiens
Bioorg. Med. Chem. Lett.
21
4884-4887
2011
14
-
-
-
-
-
-
-
1
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
14
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
714445
Knaus
Phenylethynylbenzenesulfonamid ...
Homo sapiens
Bioorg. Med. Chem. Lett.
21
5892-5896
2011
-
-
-
-
-
-
23
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
67
-
-
-
-
-
-
-
-
-
-
23
67
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
714446
Bertucci
Carbonic anhydrase inhibitors. ...
Stylophora pistillata
Bioorg. Med. Chem. Lett.
21
710-714
2011
-
-
-
-
-
-
60
-
2
1
-
1
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
43
-
-
-
-
-
-
-
-
-
-
60
43
-
2
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
714456
Joseph
A new beta-carbonic anhydrase ...
Brucella suis 1330, Brucella suis
Bioorg. Med. Chem.
19
1172-1178
2011
-
-
1
-
-
-
33
-
-
1
1
2
-
4
-
-
1
-
-
-
-
-
2
2
-
-
-
2
1
-
-
-
64
-
-
-
-
1
-
-
-
-
-
33
64
-
-
1
1
2
-
-
-
1
-
-
-
-
2
2
-
-
-
2
1
-
-
-
-
1
1
-
2
2
714459
Durdagi
Kinetic and docking studies of ...
Homo sapiens
Bioorg. Med. Chem.
19
1381-1389
2011
-
-
-
-
-
-
13
-
2
1
-
1
-
1
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
47
-
-
-
-
-
-
-
-
-
-
13
47
-
2
1
-
1
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
714462
Cincinelli
Purification and inhibition st ...
Leptonychotes weddellii
Bioorg. Med. Chem.
19
1847-1851
2011
-
-
-
-
-
-
31
-
-
1
1
1
-
4
-
-
-
-
-
6
-
-
1
1
1
-
-
-
1
-
-
-
-
-
19
-
-
-
-
-
-
-
19
31
-
-
-
1
1
1
-
-
-
-
-
6
-
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
714467
Xiao
Synthesis and evaluation of ne ...
Homo sapiens
Bioorg. Med. Chem.
19
3221-3228
2011
-
-
1
-
-
-
40
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
40
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
714469
Biswas
Conformational variability of ...
Homo sapiens
Bioorg. Med. Chem.
19
3732-3738
2011
-
-
-
1
-
-
6
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
10
-
-
-
-
-
-
1
-
-
-
6
10
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
714700
Sentuerk
In vitro inhibition of human c ...
Homo sapiens
Chem. Biol. Drug Des.
77
494-499
2011
-
-
-
-
-
-
7
-
2
-
-
1
-
2
-
-
1
-
-
1
-
-
2
-
1
-
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
1
7
1
-
2
-
-
1
-
-
-
1
-
1
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
714853
Ceyhun
Purification and characterizat ...
Dicentrarchus labrax
Environ. Toxicol. Pharmacol.
32
69-74
2011
-
-
-
-
-
-
8
1
-
1
1
-
-
5
-
-
1
-
-
3
1
-
1
1
1
1
-
-
1
-
1
-
1
-
1
-
-
-
-
-
-
-
1
8
1
1
-
1
1
-
-
-
-
1
-
3
1
-
1
1
1
1
-
-
1
-
1
-
-
-
-
-
-
-
714862
Sharma
Biomimetic CO2 sequestration u ...
Micrococcus luteus, Micrococcus luteus 2, Micrococcus lylae, Pseudomonas fragi
Enzyme Microb. Technol.
48
416-426
2011
-
-
-
-
3
-
-
-
-
-
-
4
-
8
-
-
-
-
-
-
6
-
4
-
3
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
6
-
4
-
3
-
-
-
3
-
-
-
-
-
-
-
-
-
715746
Kolayli
Characterization and inhibitio ...
Acipenser gueldenstaedtii
J. Enzyme Inhib. Med. Chem.
26
895-900
2011
-
-
-
-
-
-
11
2
-
-
1
1
-
4
-
-
1
-
-
3
1
-
2
1
1
-
-
2
1
-
-
-
2
-
11
-
-
-
-
-
-
-
11
11
2
2
-
-
1
1
-
-
-
1
-
3
1
-
2
1
1
-
-
2
1
-
-
-
-
1
1
-
-
-
716173
Fasseas
Molecular and biochemical anal ...
Caenorhabditis elegans
Mol. Biol. Rep.
38
1777-1785
2011
-
-
1
-
1
-
-
-
-
1
-
1
-
1
-
-
1
-
-
1
-
-
1
-
1
-
-
1
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
1
-
1
-
-
1
-
1
-
-
1
1
-
-
-
-
-
-
-
1
1
716412
Dave
Pyridinium derivatives of hist ...
Homo sapiens
Org. Biomol. Chem.
9
2790-2800
2011
26
-
-
-
-
-
-
-
1
1
-
1
-
2
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
26
-
-
-
-
-
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
716443
Amata
Catalytic activity of a zeta-c ...
Conticribra weissflogii, Methanosarcina thermophila
Phys. Chem. Chem. Phys.
13
3468-3477
2011
-
-
-
-
-
-
-
-
-
4
-
2
-
3
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
729554
Weise
Substrate-dependent interferen ...
Escherichia coli
Cell. Physiol. Biochem.
27
79-90
2011
-
-
-
-
1
-
1
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
730118
Ozensoy
Carbonic anhydrase inhibitors: ...
Columba livia
J. Enzyme Inhib. Med. Chem.
26
749-753
2011
-
-
1
-
-
-
25
-
-
-
1
-
-
7
-
-
1
-
-
3
-
-
1
-
1
-
-
1
1
-
-
-
25
-
-
-
-
1
-
-
-
-
-
25
25
-
-
-
1
-
-
-
-
1
-
3
-
-
1
-
1
-
-
1
1
-
-
-
-
-
-
-
1
1
730551
Ignatova
Carbonic anhydrase activity in ...
Arabidopsis thaliana
Photosyn. Res.
110
89-98
2011
-
-
-
-
-
-
2
-
3
-
-
-
-
4
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
3
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
702367
Avvaru
A short, strong hydrogen bond ...
Homo sapiens
Biochemistry
49
249-251
2010
-
-
-
-
-
-
1
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702470
De Simone
Carbonic anhydrase IX: Biochem ...
Homo sapiens
Biochim. Biophys. Acta
1804
404-409
2010
-
1
1
-
-
-
1
1
1
1
-
-
-
3
-
-
-
-
-
-
-
-
1
1
-
-
-
1
-
-
-
-
1
-
-
-
1
1
-
-
-
-
-
1
1
1
1
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
1
-
-
-
-
1
1
1
1
1
1
702518
Sugimoto
Timolol activates the enzyme a ...
Homo sapiens
Biol. Pharm. Bull.
33
301-306
2010
1
-
-
-
-
-
-
5
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702616
Innocenti
Carbonic anhydrase activators: ...
Candida glabrata
Bioorg. Med. Chem. Lett.
20
1701-1704
2010
19
-
-
-
-
-
-
1
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
19
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
702618
Vullo
Inhibition studies of a beta-c ...
Brucella suis
Bioorg. Med. Chem. Lett.
20
2178-2182
2010
-
-
-
-
-
-
10
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
10
-
-
-
-
-
-
-
-
-
-
10
10
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
702675
Innocenti
Carbonic anhydrase activators: ...
Candida albicans, Cryptococcus neoformans
Bioorg. Med. Chem.
18
1034-1037
2010
36
-
-
-
-
-
-
2
3
-
-
-
-
5
-
-
-
-
-
-
-
-
2
-
-
-
-
4
-
-
-
-
-
-
-
36
-
-
-
-
-
-
-
-
-
2
3
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
702679
Davis
Carbonic anhydrase inhibitors. ...
Homo sapiens
Bioorg. Med. Chem.
18
14-18
2010
-
-
-
-
-
-
31
-
4
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
104
-
-
-
-
-
-
-
-
-
-
31
104
-
4
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702683
Bertucci
Carbonic anhydrase activators. ...
Stylophora pistillata
Bioorg. Med. Chem.
18
2300-2303
2010
17
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
17
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
702687
Innocenti
Nanoscale enzyme inhibitors: f ...
Homo sapiens
Bioorg. Med. Chem.
18
2822-2828
2010
-
-
-
-
-
-
4
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
703311
Roberto
Carbonic anhydrase activity in ...
Mytilus galloprovincialis
Comp. Biochem. Physiol. C
152
241-247
2010
-
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
1
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
2
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
703554
Benfodda
Synthesis and investigation of ...
Bos taurus, Homo sapiens
Eur. J. Med. Chem.
45
1225-1229
2010
-
-
-
-
-
-
26
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
26
5
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
703558
Brzozowski
Carbonic anhydrase inhibitors: ...
Homo sapiens
Eur. J. Med. Chem.
45
2396-2404
2010
-
-
-
-
-
-
29
-
3
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
136
-
-
-
-
-
-
-
-
-
-
29
136
-
3
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
704853
Baranauskiene
Inhibition and binding studies ...
Homo sapiens
J. Enzyme Inhib. Med. Chem.
25
863-870
2010
-
-
1
1
-
-
11
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
11
-
-
-
-
1
-
1
-
-
-
11
11
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
705063
Joseph
Cloning, characterization, and ...
Brucella suis
J. Med. Chem.
53
2277-2285
2010
-
-
1
-
-
-
39
-
-
-
1
-
-
4
-
-
1
-
-
-
-
-
1
1
-
-
-
1
-
-
-
-
32
-
-
-
-
1
-
-
-
-
-
39
32
-
-
-
1
-
-
-
-
1
-
-
-
-
1
1
-
-
-
1
-
-
-
-
-
-
-
-
1
1
705064
Gitto
Identification of 3,4-dihydroi ...
Homo sapiens
J. Med. Chem.
53
2401-2408
2010
-
-
-
1
-
-
13
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
52
-
-
-
-
-
-
1
-
-
-
26
52
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
705068
Maresca
Deciphering the mechanism of c ...
Homo sapiens
J. Med. Chem.
53
335-344
2010
-
-
-
1
-
-
21
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
211
-
-
-
-
-
-
1
-
-
-
21
211
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
706555
Pena
Structural basis of the oxidat ...
Thermosynechococcus elongatus
Proc. Natl. Acad. Sci. USA
107
2455-2460
2010
-
-
1
1
-
-
-
-
1
-
-
-
-
6
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
713627
Suzuki
Crystallographic study of wild ...
Chlamydomonas reinhardtii
Acta Crystallogr. Sect. F
66
1082-1085
2010
-
-
-
1
-
-
-
-
-
1
-
-
-
2
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
713951
Avvaru
Comparison of solution and cry ...
Homo sapiens
Arch. Biochem. Biophys.
502
53-59
2010
-
-
1
1
-
-
1
-
-
2
-
1
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
2
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
714191
Rowlett
Evidence for a bicarbonate esc ...
Haemophilus influenzae
Biochemistry
49
3640-3647
2010
-
-
1
1
2
-
-
1
-
2
-
1
-
2
-
-
1
1
-
-
-
-
3
1
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
2
-
-
-
-
1
-
2
-
1
-
-
-
1
-
-
-
-
3
1
1
-
-
-
-
-
-
-
-
1
1
-
-
-
714203
Domsic
Structural and kinetic study o ...
Homo sapiens
Biochemistry
49
6394-6399
2010
-
-
1
1
4
-
-
-
-
1
-
1
-
2
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
4
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
714423
Maresca
7,8-disubstituted- but not 6,7 ...
Homo sapiens
Bioorg. Med. Chem. Lett.
20
7255-7258
2010
-
-
-
-
-
-
23
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
40
-
-
-
-
-
-
-
-
-
-
23
40
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
714606
Syrjaenen
Characterization of the first ...
Drosophila melanogaster
BMC Biochem.
11
28
2010
-
1
1
-
-
-
21
-
2
-
-
1
-
5
-
-
-
-
-
-
-
-
1
1
1
-
-
1
1
-
-
-
21
-
-
-
1
1
-
-
-
-
-
21
21
-
2
-
-
1
-
-
-
-
-
-
-
-
1
1
1
-
-
1
1
-
-
-
-
1
1
-
1
1
714793
Isik
Saccharomyces cerevisiae beta- ...
Saccharomyces cerevisiae
Curr. Pharm. Des.
16
3327-3336
2010
2
-
-
-
-
-
5
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
5
1
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
715948
Sharma
-
Enhanced biomimetic sequestrat ...
Bos taurus, Micrococcus luteus, Micrococcus luteus 2, Micrococcus lylae, Pseudomonas fragi
J. Mol. Catal. B
67
122-128
2010
-
4
-
-
-
-
50
-
-
-
-
-
-
6
-
-
-
-
-
1
4
-
-
-
4
-
8
-
4
-
4
-
-
-
-
-
4
-
-
-
-
-
-
50
-
-
-
-
-
-
-
-
-
-
-
1
4
-
-
-
4
-
8
-
4
-
4
-
-
4
4
-
-
-
716583
Wang
-
Effects of physical and chemic ...
Haematococcus lacustris, Haematococcus lacustris CG-11
Plant Physiol. Commun.
46
701-706
2010
2
-
-
-
-
-
1
-
-
1
-
-
-
2
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
716685
Wandernoth
Role of carbonic anhydrase IV ...
Homo sapiens, Mus musculus, Mus musculus C57/BL6J
PLoS ONE
5
e15061
2010
-
-
-
-
-
-
-
-
4
-
-
-
-
65
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
727748
Zimmerman
Characterization of CamH from ...
Methanosarcina thermophila, Methanosarcina thermophila TM-1
J. Bacteriol.
192
1353-1360
2010
3
-
1
-
-
-
-
2
-
2
2
-
-
2
1
-
1
-
-
3
-
-
2
1
1
-
-
2
1
-
-
-
-
-
-
3
-
1
-
-
-
-
-
-
-
2
-
2
2
-
-
1
-
1
-
3
-
-
2
1
1
-
-
2
1
-
-
-
1
-
-
1
2
2
696308
Genis
Design of a carbonic anhydrase ...
Homo sapiens
Biochemistry
48
1322-1331
2009
-
-
1
1
2
-
5
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
9
-
-
-
-
1
-
1
2
-
-
5
9
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696355
Macauley
The archetype gamma-class carb ...
Methanosarcina thermophila
Biochemistry
48
817-819
2009
-
-
1
-
-
-
-
-
-
2
-
-
-
4
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696695
Bertucci
Carbonic anhydrase inhibitors: ...
Stylophora pistillata
Bioorg. Med. Chem. Lett.
19
650-653
2009
-
-
-
-
-
-
21
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
20
-
-
-
-
-
-
-
-
-
-
21
20
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696740
Isik
Carbonic anhydrase inhibitors: ...
Saccharomyces cerevisiae
Bioorg. Med. Chem.
17
1158-1163
2009
-
-
1
-
-
-
37
-
-
-
-
1
-
4
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
16
-
21
-
-
1
-
-
-
-
21
37
16
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
697451
Pongsomboon
Gene expression and activity o ...
Penaeus monodon
Comp. Biochem. Physiol. A
152
225-233
2009
1
-
-
-
-
-
1
-
-
-
-
-
-
3
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699246
Nishimori
Carbonic anhydrase inhibitors. ...
Homo sapiens
J. Enzyme Inhib. Med. Chem.
24
70-76
2009
-
-
-
-
-
-
17
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
17
4
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
699461
Temperini
Carbonic anhydrase inhibitors. ...
Homo sapiens
J. Med. Chem.
52
322-328
2009
-
-
-
1
-
-
6
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
63
-
-
-
-
-
-
1
-
-
-
6
63
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699472
Hilvo
Cloning, expression, post-Tran ...
Mus musculus
J. Med. Chem.
52
646-654
2009
-
-
1
-
-
-
38
1
1
-
-
-
-
4
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
38
-
-
-
-
1
-
-
-
-
-
38
38
1
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
699561
Schlicker
Structure and inhibition of th ...
Cryptococcus neoformans
J. Mol. Biol.
385
1207-1220
2009
-
-
-
1
-
-
37
-
-
1
-
-
-
5
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
36
-
-
-
-
-
-
1
-
-
-
37
36
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699957
Malentacchi
Alternative splicing variants ...
Homo sapiens
Lung Cancer
64
271-276
2009
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700632
Frison
Metal-histidine-glutamate as a ...
Homo sapiens
Phys. Chem. Chem. Phys.
11
374-383
2009
-
-
-
-
-
-
-
-
-
1
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701131
Di Fiore
Crystal structure of human car ...
Homo sapiens
Proteins
74
164-175
2009
-
-
1
1
-
-
1
1
2
1
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
1
1
1
2
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
701985
Tasgin
-
Purification and properties of ...
Bos taurus
Asian J. Chem.
21
5117-5122
2009
-
-
-
-
-
-
4
1
-
-
1
1
-
1
-
-
1
-
-
1
2
-
2
-
1
1
-
-
1
1
-
-
4
-
4
-
-
-
-
-
-
-
4
4
4
1
-
-
1
1
-
-
-
1
-
1
2
-
2
-
1
1
-
-
1
1
-
-
-
-
-
-
-
-
702339
Maupin
Effect of active-site mutation ...
Homo sapiens
Biochemistry
48
7996-8005
2009
-
-
1
-
1
-
-
-
-
1
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702555
Innocenti
Carbonic anhydrase inhibitors: ...
Mus musculus
Bioorg. Med. Chem. Lett.
19
1155-1158
2009
-
-
-
-
-
-
20
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
19
-
-
-
-
-
-
-
-
-
-
20
19
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702563
Abdo
Carbonic anhydrase activators: ...
Homo sapiens
Bioorg. Med. Chem. Lett.
19
2440-2443
2009
14
-
-
-
-
-
-
-
2
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
14
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702571
Guezel
Carbonic anhydrase inhibitors. ...
Homo sapiens
Bioorg. Med. Chem. Lett.
19
3170-3173
2009
-
-
-
-
-
-
21
-
2
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
21
-
-
-
-
-
-
-
-
-
-
21
21
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702654
Guezel
Carbonic anhydrase inhibitors. ...
Homo sapiens
Bioorg. Med. Chem.
17
4894-4899
2009
-
-
-
-
-
-
20
-
4
-
-
3
-
4
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
79
-
-
-
-
-
-
-
80
60
-
-
5
-
-
3
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702655
Bertucci
Carbonic anhydrase inhibitors. ...
Stylophora pistillata
Bioorg. Med. Chem.
17
5054-5058
2009
-
-
-
-
-
-
37
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
37
-
-
-
-
-
-
-
-
-
-
37
37
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702804
Ramanan
-
Purification and characterizat ...
Bacillus subtilis, Bacillus subtilis SA3
Biotechnol. Bioprocess Eng.
14
32-37
2009
-
-
-
-
-
-
11
1
-
6
1
-
-
2
-
-
1
-
-
-
2
-
4
-
1
-
1
-
1
-
1
-
2
1
-
-
-
-
-
-
-
-
-
11
2
1
-
6
1
-
-
-
-
1
-
-
2
-
4
-
1
-
1
-
1
-
1
1
-
-
-
-
-
-
702846
Liu
Production, purification, and ...
Neisseria gonorrhoeae
Biotechnol. Prog.
25
68-74
2009
-
-
1
-
-
-
-
-
-
1
1
-
-
3
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
702932
Teng
Structural insights into the s ...
Saccharomyces cerevisiae
BMC Struct. Biol.
9
67
2009
-
-
1
1
1
-
-
-
-
1
-
-
-
5
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
703005
Li
Expression and activity of car ...
Homo sapiens
Cancer Invest.
27
613-623
2009
-
1
-
-
-
-
-
-
1
-
2
-
-
2
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
703159
Carta
Carbonic anhydrase inhibitors: ...
Homo sapiens
Chem. Biol. Drug Des.
74
196-202
2009
-
-
-
-
-
-
14
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
26
-
-
-
-
-
-
-
-
-
-
14
26
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
703758
Kaur
Regulation of expression and b ...
Azospirillum brasilense, Azospirillum brasilense Sp7
FEMS Microbiol. Lett.
299
149-158
2009
-
-
1
-
-
1
5
-
-
-
2
-
-
9
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
4
-
-
1
-
-
-
1
4
5
-
-
-
-
2
-
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
704286
Kalloniati
Characterization of a Mesorhiz ...
Mesorhizobium loti, Mesorhizobium loti R7A
J. Bacteriol.
191
2593-2600
2009
-
-
1
-
-
-
-
2
-
1
2
-
-
6
-
-
1
-
-
-
2
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
1
2
-
-
-
-
1
-
-
2
-
2
-
-
-
-
2
-
-
-
-
1
-
-
1
-
-
705027
Minakuchi
Molecular cloning, characteriz ...
Mycobacterium tuberculosis
J. Med. Chem.
52
2226-2232
2009
-
-
1
-
-
-
38
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
37
-
-
-
-
1
-
-
-
-
-
38
37
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
705034
Nishimori
Carbonic anhydrase inhibitors. ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
J. Med. Chem.
52
3116-3120
2009
-
-
1
-
-
-
38
-
-
-
-
-
-
154
-
-
1
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
60
-
-
-
-
1
-
-
-
-
-
38
60
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
706515
Alterio
Crystal structure of the catal ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
106
16233-16238
2009
-
1
1
1
-
-
-
-
1
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
1
1
-
-
-
706571
Sharma
-
Purification and characterizat ...
Pseudomonas fragi
Process Biochem.
44
1293-1297
2009
-
-
-
-
-
-
16
-
1
4
2
-
-
1
-
-
1
-
-
-
1
-
2
1
1
-
1
-
1
-
1
-
-
-
12
-
-
-
-
-
-
-
12
16
-
-
1
4
2
-
-
-
-
1
-
-
1
-
2
1
1
-
1
-
1
-
1
-
1
-
-
1
-
-
706653
Picaud
Crystal structure of human car ...
Homo sapiens
Proteins
76
507-511
2009
-
-
1
1
-
-
-
-
-
-
-
1
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
678696
Guezel
Carbonic anhydrase inhibitors. ...
Homo sapiens, Mus musculus
Bioorg. Med. Chem. Lett.
18
152-158
2008
-
-
-
1
-
-
10
-
-
-
-
-
-
12
-
-
-
-
-
-
-
-
12
-
-
-
-
-
-
-
-
-
55
-
-
-
-
-
-
1
-
-
-
60
60
-
-
-
-
-
-
-
-
-
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695315
Jeyakanthan
Observation of a calcium-bindi ...
Pyrococcus horikoshii, Pyrococcus horikoshii OT-3
Acta Crystallogr. Sect. D
64
1012-1019
2008
-
-
1
1
-
-
-
-
-
2
-
-
-
3
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696230
Zheng
Role of hydrophilic residues i ...
Homo sapiens
Biochemistry
47
12028-12036
2008
-
-
1
1
5
-
-
-
-
1
-
1
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
5
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696423
Rana
Formation of amyloid fibrils b ...
Bos taurus
Biochim. Biophys. Acta
1784
930-935
2008
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696577
Soyut
Effects of some metals on carb ...
Oncorhynchus mykiss
Biol. Trace Elem. Res.
123
179-190
2008
-
-
-
-
-
-
5
-
-
-
2
1
-
2
-
-
1
-
-
2
1
-
1
-
-
-
-
-
1
-
1
-
5
-
5
-
-
-
-
-
-
-
5
5
5
-
-
-
2
1
-
-
-
1
-
2
1
-
1
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
696613
Innocenti
Investigations of the esterase ...
Homo sapiens, Mus musculus
Bioorg. Med. Chem. Lett.
18
2267-2271
2008
-
-
-
-
-
-
2
9
-
-
-
-
-
2
-
-
-
-
-
-
-
-
5
-
-
-
-
5
-
-
-
-
-
-
6
-
-
-
-
-
-
-
6
2
-
9
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
696622
Innocenti
Carbonic anhydrase inhibitors: ...
Mus musculus
Bioorg. Med. Chem. Lett.
18
3593-3596
2008
-
-
-
-
-
-
13
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
13
-
-
-
-
-
-
-
-
-
-
13
13
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
696634
Temperini
Carbonic anhydrase inhibitors. ...
Homo sapiens, Mus musculus
Bioorg. Med. Chem. Lett.
18
4282-4286
2008
-
-
-
1
-
-
8
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
46
-
-
-
-
-
-
1
-
-
-
8
46
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696635
Vullo
Carbonic anhydrase activators: ...
Homo sapiens
Bioorg. Med. Chem. Lett.
18
4303-4307
2008
19
-
-
-
-
-
-
-
3
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
19
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696639
Innocenti
Carbonic anhydrase inhibitors: ...
Candida albicans, Cryptococcus neoformans
Bioorg. Med. Chem. Lett.
18
5066-5070
2008
-
-
-
-
-
-
42
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
40
-
-
-
-
-
-
-
-
-
-
42
40
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
696642
Krungkrai
Carbonic anhydrase inhibitors: ...
Plasmodium falciparum
Bioorg. Med. Chem. Lett.
18
5466-5471
2008
-
-
-
-
-
-
36
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
35
-
35
-
-
-
-
-
-
-
35
36
35
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696648
Innocenti
Carbonic anhydrase activators: ...
Methanosarcina thermophila, Methanothermobacter thermautotrophicus
Bioorg. Med. Chem. Lett.
18
6194-6198
2008
36
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
36
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696649
Isik
Carbonic anhydrase inhibitors. ...
Saccharomyces cerevisiae
Bioorg. Med. Chem. Lett.
18
6327-6331
2008
-
-
-
-
-
-
21
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
19
-
-
-
-
-
-
-
-
-
-
21
19
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
696737
Bayram
In vitro inhibition of salicyl ...
Homo sapiens
Bioorg. Med. Chem.
16
9101-9105
2008
-
-
-
-
-
-
11
-
2
-
-
1
-
2
-
-
1
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
20
-
20
-
-
-
-
-
-
-
20
11
20
-
2
-
-
1
-
-
-
1
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696955
Bootorabi
Modification of carbonic anhyd ...
Homo sapiens
BMC Biochem.
9
32
2008
-
-
1
-
-
-
2
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
1
1
-
-
-
1
-
-
-
-
-
2
1
1
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
697163
Lazova
A 160 kDa protein with carboni ...
Pisum sativum
Cell Biol. Int.
32
646-653
2008
-
-
-
-
-
-
-
-
2
-
2
-
-
3
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697325
Marie
Nacre calcification in the fre ...
Unio pictorum
ChemBioChem
9
2515-2523
2008
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697525
Hilvo
Recent advances in research on ...
Homo sapiens, Mus musculus
Curr. Pharm. Des.
14
672-678
2008
-
-
-
-
-
-
2
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
697643
Ye
The odd behaviour of carbonic ...
Nostoc flagelliforme
Environ. Microbiol.
10
1018-1023
2008
1
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698192
Choi
Expression of carbonic anhydra ...
Homo sapiens
Hum. Pathol.
39
1317-1322
2008
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698379
Sun
Role of carbonic anhydrase IV ...
Bos taurus
Invest. Ophthalmol. Vis. Sci.
49
1048-1055
2008
-
-
-
-
-
-
1
-
1
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698458
Maupin
Origins of enhanced proton tra ...
Homo sapiens
J. Am. Chem. Soc.
130
11399-11408
2008
-
-
-
-
1
-
-
-
-
1
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698469
Gokhale
Catalytic inactivation of huma ...
Homo sapiens
J. Am. Chem. Soc.
130
2388-2389
2008
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698797
Moya
Carbonic anhydrase in the scle ...
Stylophora pistillata
J. Biol. Chem.
283
25475-25484
2008
1
-
1
-
-
-
1
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
698814
Hilvo
Biochemical characterization o ...
Homo sapiens
J. Biol. Chem.
283
27799-27809
2008
-
-
1
-
-
-
1
4
1
4
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
6
-
-
-
-
8
-
-
-
-
1
-
-
-
-
-
1
8
4
1
4
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
698827
Domsic
Entrapment of carbon dioxide i ...
Homo sapiens
J. Biol. Chem.
283
30766-30771
2008
-
-
1
1
-
-
1
-
-
1
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699227
Coban
The effect of ethanol on eryth ...
Homo sapiens, Rattus norvegicus
J. Enzyme Inhib. Med. Chem.
23
266-270
2008
-
-
-
-
-
-
2
-
-
-
-
-
-
5
-
-
1
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
-
1
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699234
Buelbuel
Amide derivatives with pyrazol ...
Homo sapiens
J. Enzyme Inhib. Med. Chem.
23
895-900
2008
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699426
Wilkinson
Inhibition of carbonic anhydra ...
Homo sapiens
J. Med. Chem.
51
1945-1953
2008
-
-
-
-
-
-
26
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
69
-
-
-
-
-
-
-
-
-
-
26
69
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699919
Gailly
A novel renal carbonic anhydra ...
Mus musculus
Kidney Int.
74
52-61
2008
1
-
-
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700140
Dai
Carbonic anhydrase III promote ...
Homo sapiens
Mol. Carcinog.
47
956-963
2008
-
-
1
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700383
Xu
Structure and metal exchange i ...
Conticribra weissflogii
Nature
452
56-61
2008
-
-
-
1
-
-
-
-
-
2
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700410
Haapasalo
Identification of an alternati ...
Homo sapiens
Neuro-oncology
10
131-138
2008
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
7
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
7
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700635
Martin
Bicarbonate transport and extr ...
Asterionella glacialis, Chaetoceros decipiens, Chaetoceros socialis, Chaetoceros vixvisibilis, Conticribra weissflogii, Cylindrotheca fusiformis, Grammatophora oceanica, Leptocylindrus minimus, Leyanella arenaria, Nitzschia thermalis, Odontella aurita, Phaeodactylum tricornutum, Pseudo-nitzschia granii, Pseudo-nitzschia turgidula, Skeletonema costatum, Thalassiosira oceanica, Thalassiosira pseudonana
Physiol. Plant.
133
106-116
2008
-
-
-
-
-
-
17
-
17
-
-
-
-
20
-
-
-
-
-
-
-
-
17
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
17
-
-
17
-
-
-
-
-
-
-
-
-
-
-
17
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700636
Ynalvez
Identification and characteriz ...
Chlamydomonas reinhardtii, Chlamydomonas reinhardtii D66
Physiol. Plant.
133
15-26
2008
1
-
1
-
-
-
4
-
1
1
3
-
-
2
-
-
1
-
-
-
1
-
2
1
-
-
-
-
-
-
-
-
-
-
8
1
-
1
-
-
-
-
8
4
-
-
1
1
3
-
-
-
-
1
-
-
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700637
Kitao
Localization and targeting mec ...
Phaeodactylum tricornutum, Phaeodactylum tricornutum UTEX642
Physiol. Plant.
133
68-77
2008
-
-
-
-
-
-
-
-
1
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700638
McGinn
Expression and regulation of c ...
Thalassiosira pseudonana
Physiol. Plant.
133
78-91
2008
-
-
-
-
-
-
-
-
-
-
1
-
-
9
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
700804
Lapointe
An external delta-carbonic anh ...
Lingulodinium polyedra
Plant Physiol.
147
1427-1436
2008
-
-
-
-
-
-
1
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700808
Ferreira
Reduction of plastid-localized ...
Arabidopsis thaliana
Plant Physiol.
147
585-594
2008
-
-
-
-
-
-
-
-
3
-
-
-
-
4
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700825
Duanmu
Thylakoid lumen carbonic anhyd ...
Chlamydomonas reinhardtii
Plant Physiol.
149
929-937
2008
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700971
Inada
Carbonic anhydrase II-positive ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
105
19915-19919
2008
-
-
1
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701088
Soyut
Purification and some kinetic ...
Oncorhynchus mykiss
Protein Pept. Lett.
15
528-535
2008
-
-
-
-
-
-
4
-
-
-
2
-
-
2
-
-
1
-
-
2
-
-
-
-
1
-
-
-
2
-
1
-
4
-
4
-
-
-
-
-
-
-
4
4
4
-
-
-
2
-
-
-
-
1
-
2
-
-
-
-
1
-
-
-
2
-
1
-
-
-
-
-
-
-
678267
Fisher
Speeding up proteon transfer i ...
Homo sapiens
Biochemistry
46
3803-3813
2007
-
-
1
1
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
678412
McConnell
A quantitative assessment of t ...
Spinacia oleracea
Biochim. Biophys. Acta
1767
639-647
2007
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
678563
Wu
Impact of Zn, Cu, and Fe on th ...
Anas platyrhynchos
Biol. Trace Elem. Res.
118
227-232
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
678614
Nishimori
Carbonic anhydrase inhibitors: ...
Homo sapiens
Bioorg. Med. Chem.
15
7229-7236
2007
-
-
1
-
-
-
38
-
2
-
-
-
-
2
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
38
-
-
-
-
1
-
-
-
-
-
38
38
-
2
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
678660
Temperini
Carbonic anhydrase inhibitors: ...
Homo sapiens
Bioorg. Med. Chem. Lett.
17
2795-2801
2007
-
-
-
1
-
-
4
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
14
-
-
-
-
-
-
1
-
-
-
14
14
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
678676
Alterio
Carbonic anhydrase inhibitors: ...
Helicobacter pylori, Homo sapiens, Methanosarcina thermophila, Mus musculus
Bioorg. Med. Chem. Lett.
17
4201-4207
2007
-
-
-
-
-
-
39
-
-
-
-
-
-
16
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
148
-
-
-
-
-
-
-
-
-
-
156
152
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
678681
Temperini
Carbonic anhydrase inhibitors. ...
Homo sapiens, Mus musculus
Bioorg. Med. Chem. Lett.
17
4866-4872
2007
-
-
-
1
-
-
2
-
-
-
-
-
-
11
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
11
-
-
-
-
-
-
1
-
-
-
11
11
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
678712
Temperini
Carbonic anhydrase inhibitors. ...
Homo sapiens, Mus musculus
Bioorg. Med. Chem. Lett.
18
999-1005
2007
-
-
-
1
-
-
2
-
-
-
-
-
-
12
-
-
-
-
-
-
-
-
12
-
-
-
-
-
-
-
-
-
12
-
-
-
-
-
-
1
-
-
-
12
12
-
-
-
-
-
-
-
-
-
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
678737
Marino
Structural features that gover ...
Chionodraco hamatus, Homo sapiens
Biophys. J.
93
2781-2790
2007
-
-
-
2
-
-
-
-
1
1
-
-
-
5
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
1
1
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
679314
Roy
Branchial carbonic anhydrase a ...
Penaeus vannamei
Comp. Biochem. Physiol. A
147
404-411
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
679413
Hilvo
Characterization and inhibitio ...
Homo sapiens, Mus musculus, no activity in Homo sapiens
Curr. Top. Med. Chem.
7
893-899
2007
-
-
1
1
-
-
25
-
6
-
-
-
-
7
-
1
-
-
-
33
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
25
1
-
6
-
-
-
-
-
1
-
-
36
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
680115
Demir
Purification and some properti ...
Elephas trogontherii
Indian J. Biochem. Biophys.
44
252-256
2007
-
-
-
-
-
-
5
4
2
-
4
-
-
2
-
-
1
-
-
2
-
-
1
-
3
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
4
2
-
4
-
-
-
-
1
-
2
-
-
1
-
3
-
-
-
3
-
-
-
-
-
-
-
-
-
680579
Hollowell
Thermodynamic analysis of the ...
Bos taurus
J. Biochem. Mol. Biol.
40
205-211
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
680764
Becker
Carbonic anhydrase II increase ...
Homo sapiens
J. Biol. Chem.
282
13508-13521
2007
-
-
-
-
-
-
-
-
2
-
-
1
-
3
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
681115
Serrano
Salinity-stimulated changes in ...
Callinectes sapidus
J. Exp. Biol.
210
2320-2332
2007
-
-
-
-
-
-
-
-
3
-
-
-
-
3
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
681312
Nishimori
Carbonic anhydrase inhibitors. ...
Homo sapiens
J. Med. Chem.
50
381-388
2007
-
-
1
-
-
-
34
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
34
-
-
-
-
1
-
-
-
-
-
34
34
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
681738
Rahman
Carbonic anhydrase in calcifie ...
Lobophytum crassum
Mar. Biotechnol.
10
31-38
2007
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
682073
Gao
Extracellular carbonic anhydra ...
Homo sapiens
Nat. Med.
13
181-188
2007
-
-
-
-
-
-
-
-
1
-
-
1
-
3
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
682267
Rudenko
Multiple sources of carbonic a ...
Pisum sativum
Photosyn. Res.
91
81-89
2007
-
-
-
-
-
-
-
-
5
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
682333
Fabre
Characterization and expressio ...
Arabidopsis thaliana
Plant Cell Environ.
30
617-629
2007
-
-
-
-
-
-
-
-
4
-
-
2
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
682418
Tetu
The Flaveria bidentis beta-car ...
Flaveria bidentis, Flaveria bidentis Kuntze
Plant Physiol.
144
1316-1327
2007
-
-
-
-
-
-
-
-
4
-
-
6
-
9
-
-
-
-
-
4
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
6
-
-
-
-
-
10
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
682665
Yu
Purification and characterizat ...
Oryza sativa
Protein Expr. Purif.
52
379-383
2007
-
-
1
-
-
-
6
-
-
1
1
-
-
3
-
-
1
-
-
-
1
-
1
1
-
-
-
1
-
-
-
-
6
1
-
-
-
1
-
-
-
-
-
6
6
-
-
1
1
-
-
-
-
1
-
-
1
-
1
1
-
-
-
1
-
-
-
1
-
-
-
-
-
-
682703
Rizzello
Biochemical characterization o ...
Chionodraco hamatus
Protein J.
26
335-348
2007
-
-
-
-
-
-
-
-
2
-
2
-
-
4
-
1
-
-
-
2
-
-
-
1
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
1
-
-
2
-
-
-
1
1
1
-
-
-
-
-
1
-
-
-
-
-
-
682762
Elder
Structural and kinetic analysi ...
Homo sapiens
Proteins
68
337-343
2007
-
-
-
1
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698576
Swingley
The complete genome sequence o ...
Roseobacter denitrificans OCh 114
J. Bacteriol.
189
683-690
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
678350
Ignatova
Heterogeneous origin of carbon ...
Pisum sativum
Biochemistry
71
525-532
2006
1
-
-
-
-
-
2
-
3
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
3
1
-
-
-
-
-
-
3
2
-
-
3
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
678479
Fisher
Expression, purification, kine ...
Aedes aegypti
Biochim. Biophys. Acta
764
1413-1419
2006
-
1
1
-
-
-
2
-
-
-
-
-
-
5
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
1
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
680179
Beydemir
-
Carbonic anhydrase: affinity p ...
Oncorhynchus mykiss
Int. J. Appl. Chem.
2
45-55
2006
-
-
-
-
-
-
1
1
-
-
2
-
-
1
-
-
1
-
-
1
1
-
1
1
1
1
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
-
-
1
1
1
-
-
2
-
-
-
-
1
-
1
1
-
1
1
1
1
-
-
1
-
1
-
-
-
-
-
-
-
680472
Heinhorst
Characterization of the carbox ...
Halothiobacillus neapolitanus
J. Bacteriol.
188
8087-8094
2006
-
-
1
-
-
-
3
2
2
1
-
-
-
4
-
-
1
-
-
-
-
-
2
-
-
-
-
2
-
2
-
-
-
-
3
-
-
1
-
-
-
-
3
3
-
2
2
1
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
680740
Sawaya
The structure of beta-carbonic ...
Halothiobacillus neapolitanus
J. Biol. Chem.
281
7546-7555
2006
-
-
1
1
-
-
-
-
1
-
-
1
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
681114
Esbaugh
Tribute to R. G. Boutilier: ev ...
Petromyzon marinus
J. Exp. Biol.
209
1169-1178
2006
-
-
1
-
-
-
1
-
1
-
-
1
-
6
-
-
-
-
-
7
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
7
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
682948
Tiwari
Carbonic anhydrase in Tectona ...
Tectona grandis
Tree Physiol.
26
1067-1073
2006
-
1
-
-
-
-
-
1
-
-
-
-
-
3
-
-
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
663971
Hilvo
Characterization of CA XV, a n ...
Homo sapiens, Mus musculus, Pan troglodytes
Biochem. J.
392
83-92
2005
-
-
1
-
-
-
-
-
1
-
-
-
-
6
-
1
-
-
-
3
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
3
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
664052
Duda
Human carbonic anhydrase III: ...
Homo sapiens
Biochemistry
44
10046-10053
2005
-
-
-
1
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
664306
zensoy
Carbonic anhydrase inhibitors: ...
Homo sapiens
Bioorg. Med. Chem.
13
6089-6093
2005
-
-
-
-
-
-
27
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
81
-
-
-
-
-
-
-
-
-
-
81
81
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
664484
Wang
Effect of heavy metals on the ...
Chlamydomonas reinhardtii
Bull. Environ. Contam. Toxicol.
74
227-233
2005
-
-
-
-
-
-
3
-
1
-
-
1
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
664670
Haritos
Carbonic anhydrase metabolism ...
Bos taurus, Tribolium castaneum
Comp. Biochem. Physiol. C
140
139-147
2005
-
-
-
-
-
-
4
1
-
-
-
1
-
4
-
-
-
-
-
1
-
-
7
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
1
-
-
-
1
-
-
-
-
-
1
-
-
7
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
665346
Wroblewski
The role of carbonic anhydrase ...
Oryctolagus cuniculus
J. Appl. Physiol.
99
488-498
2005
-
-
-
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
10
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
10
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
665394
Marcus
The periplasmic alpha-carbonic ...
Helicobacter pylori
J. Bacteriol.
187
729-738
2005
-
-
-
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
665851
zensoy
Carbonic anhydrase inhibitors. ...
Struthio camelus
J. Enzyme Inhib. Med. Chem.
20
383-387
2005
-
-
-
-
-
-
25
-
-
-
-
-
-
3
-
-
-
-
-
3
-
-
1
-
-
-
-
1
-
-
-
-
25
-
-
-
-
-
-
-
-
-
-
25
25
-
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
665852
Demir
Purification and characterizat ...
Bos taurus
J. Enzyme Inhib. Med. Chem.
20
75-80
2005
-
-
-
-
-
-
3
4
3
-
-
-
-
2
-
-
1
-
-
2
1
-
1
-
-
-
-
-
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
3
12
4
3
-
-
-
-
-
-
1
-
2
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
665857
Esbaugh
Cytoplasmic carbonic anhydrase ...
Oncorhynchus mykiss
J. Exp. Biol.
208
1951-1961
2005
-
-
-
-
-
-
2
2
2
-
-
-
-
6
-
-
-
-
-
4
-
-
2
-
-
-
-
2
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
4
4
2
2
-
-
-
-
-
-
-
-
5
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
665859
del Pilar Corena
Carbonic anhydrase in the adul ...
Aedes aegypti, Aedes albopictus, Anopheles albimanus, Anopheles quadrimaculatus, Culex nigripalpus, Culex quinquefasciatus, Ochlerotatus taeniorhynchus
J. Exp. Biol.
208
3263-3273
2005
-
-
-
-
-
-
-
-
-
-
-
7
-
14
-
-
-
-
-
7
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
7
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
665860
Kleinke
A distinct carbonic anhydrase ...
Cavia porcellus
J. Exp. Biol.
208
487-496
2005
-
-
-
-
-
-
1
-
-
-
1
-
-
8
-
-
1
-
-
6
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
6
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666589
Lu
Carbonic anhydrase activity of ...
Pisum sativum
Plant Cell Physiol.
46
1944-1953
2005
-
-
1
-
-
-
-
-
2
1
-
-
-
3
-
1
1
-
-
1
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
1
-
-
-
-
1
1
-
1
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
666638
Tanaka
Localization of soluble beta-c ...
Phaeodactylum tricornutum
Plant Physiol.
138
207-217
2005
-
-
-
-
-
-
-
-
3
-
-
-
-
5
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666735
Shah
Carbonic anhydrase IV and XIV ...
Mus musculus
Proc. Natl. Acad. Sci. USA
102
16771-16776
2005
-
-
-
-
-
-
1
-
1
-
-
2
-
5
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
2
-
1
-
-
2
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666748
Premkumar
Three-dimensional structure of ...
Dunaliella salina, Homo sapiens
Proc. Natl. Acad. Sci. USA
102
7493-7498
2005
-
-
-
1
-
1
-
6
1
1
-
-
-
4
-
-
-
-
-
-
-
-
2
1
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
6
1
1
-
-
-
-
-
-
-
-
-
-
2
1
-
-
-
6
-
-
-
-
-
-
-
-
-
-
666749
Nagelhus
Carbonic anhydrase XIV is enri ...
Mus musculus
Proc. Natl. Acad. Sci. USA
102
8030-8035
2005
-
-
-
-
-
-
-
-
2
-
-
1
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
649244
Saito
Structure of bovine carbonic a ...
Bos taurus
Acta Crystallogr. Sect. D
60
792-795
2004
-
-
-
1
-
-
-
-
-
1
1
1
-
4
-
-
1
-
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
1
1
-
-
-
1
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
649480
Elder
-
Activation of carbonic anhydra ...
Homo sapiens
Arch. Biochem. Biophys.
412
283-289
2004
-
-
1
-
5
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
5
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
649493
Rowlett
Examination of the role of Gln ...
Arabidopsis thaliana
Arch. Biochem. Biophys.
425
25-32
2004
-
-
1
-
1
-
-
-
-
-
-
1
-
3
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
652546
Lehtonen
Characterization of CA XIII, a ...
Homo sapiens, Mus musculus
J. Biol. Chem.
279
2719-2727
2004
-
-
2
-
-
-
5
-
-
2
2
2
-
4
-
-
1
-
-
18
-
-
2
-
-
-
-
-
-
-
-
-
12
-
-
-
-
2
-
-
-
-
-
5
12
-
-
2
2
2
-
-
-
1
-
18
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
652564
Whittington
Expression, assay, and structu ...
Mus musculus
J. Biol. Chem.
279
7223-7228
2004
-
-
1
1
-
-
-
-
1
1
3
1
-
3
-
1
1
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
1
1
3
1
-
-
1
1
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
665834
Esbaugh
Evidence for a membrane-bound ...
Petromyzon marinus
J. Comp. Physiol. B
174
399-406
2004
-
-
-
-
-
-
2
-
1
-
-
-
-
3
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
2
4
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
665835
Esbaugh
Comparative physiology and mol ...
Cyprinus carpio, Micropterus salmoides, Oncorhynchus mykiss, Sander vitreus
J. Comp. Physiol. B
174
429-438
2004
-
-
-
-
-
-
-
4
4
-
-
-
-
8
-
-
-
-
-
11
4
-
4
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
4
-
-
-
-
-
-
-
-
11
4
-
4
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
665974
Innocenti
Carbonic anhydrase inhibitors: ...
Homo sapiens
J. Med. Chem.
47
5224-5229
2004
-
-
-
-
-
-
25
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
49
-
-
-
-
-
-
-
-
-
-
25
49
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666540
Andrade
Carbonic anhydrase isoform exp ...
Rattus norvegicus
Pflugers Arch.
448
547-551
2004
-
-
-
-
-
-
1
-
1
-
-
1
-
4
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666801
Bageshwar
Natural protein engineering: a ...
Dunaliella salina
Protein Eng. Des. Sel.
17
191-200
2004
-
-
1
-
-
-
5
3
1
3
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
5
-
-
1
-
-
-
-
5
5
-
3
1
3
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
727132
Innocenti
Carbonic anhydrase inhibitors. ...
Methanosarcina thermophila
Bioorg. Med. Chem. Lett.
14
3327-3331
2004
-
-
-
-
-
-
23
-
-
1
-
-
-
6
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
44
-
-
-
-
-
-
-
-
-
-
26
48
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
727133
Innocenti
Carbonic anhydrase inhibitors. ...
Methanothermobacter thermautotrophicus
Bioorg. Med. Chem. Lett.
14
4563-4567
2004
-
-
-
-
-
-
17
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
16
-
-
-
-
-
-
-
-
-
-
17
16
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
727134
Zimmerman
Carbonic anhydrase inhibitors. ...
Methanosarcina thermophila, Methanothermobacter thermautotrophicus
Bioorg. Med. Chem. Lett.
14
6001-6006
2004
-
-
-
-
-
-
44
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
66
-
-
-
-
-
-
-
-
-
-
44
66
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
727848
Tripp
A role for iron in an ancient ...
Methanosarcina thermophila
J. Biol. Chem.
279
6683-6687
2004
-
-
1
-
-
-
-
1
-
3
-
-
-
6
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
1
2
728719
Simler
Zinc binding drives the foldin ...
Methanosarcina thermophila
Protein Eng. Des. Sel.
17
285-291
2004
-
-
1
-
1
-
1
-
-
1
-
-
-
2
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
649198
Premkumar
Identification, cDNA cloning, ...
Dunaliella salina
Acta Crystallogr. Sect. D
59
1084-1086
2003
-
-
1
1
-
-
-
-
1
1
1
1
-
3
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
1
1
1
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
649234
Duda
The refined atomic structure o ...
Homo sapiens
Acta Crystallogr. Sect. D
59
93-104
2003
-
-
-
1
1
-
-
-
-
1
1
1
-
2
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
1
1
1
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
650526
Scozzafava
Hydroxyurea is a carbonic anhy ...
Homo sapiens
Bioorg. Med. Chem.
11
2241-2246
2003
-
-
1
1
-
-
7
4
1
2
-
1
-
1
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
6
-
-
-
-
1
-
1
-
-
-
7
6
4
1
2
-
1
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
651596
Loferer
Influence of backbone conforma ...
Homo sapiens
J. Am. Chem. Soc.
125
8921-8927
2003
-
-
1
1
-
-
1
-
-
1
-
1
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
1
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
652642
Buelbuel
The in vitro and in vivo inhib ...
Oncorhynchus mykiss
J. Enzyme Inhib. Med. Chem.
18
371-375
2003
-
-
-
-
-
-
4
-
-
1
-
1
-
2
-
-
1
-
-
3
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
1
-
1
-
-
-
1
-
3
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
652744
Winum
Carbonic anhydrase inhibitors. ...
Homo sapiens
J. Med. Chem.
46
2197-2204
2003
-
1
1
-
-
-
34
-
2
1
-
1
-
1
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
87
-
-
-
1
1
-
-
-
-
-
34
87
-
2
1
-
1
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
652754
Winum
Carbonic anhydrase inhibitors: ...
Homo sapiens
J. Med. Chem.
46
5471-5477
2003
-
-
1
-
-
-
36
-
2
1
-
1
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
84
-
-
-
-
1
-
-
-
-
-
36
84
-
2
1
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
653761
Premkumar
An unusual halotolerant alpha- ...
Dunaliella salina
Protein Expr. Purif.
28
151-157
2003
-
-
1
-
-
1
-
-
2
-
1
1
-
3
-
-
1
-
-
1
2
3
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
2
-
1
1
-
-
-
1
-
1
2
3
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
649466
Rowlett
Kinetic characterization of wi ...
Arabidopsis thaliana
Arch. Biochem. Biophys.
404
197-209
2002
-
-
1
-
2
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
649724
Recacha
Crystal structure of human car ...
Homo sapiens
Biochem. J.
361
437-441
2002
-
-
-
1
-
-
1
-
-
1
1
1
-
2
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
1
1
1
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
650123
Tu
Chemical rescue of proton tran ...
Arabidopsis thaliana, Methanosarcina thermophila
Biochemistry
41
15429-15435
2002
-
-
-
-
2
-
-
-
-
2
-
2
-
4
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
2
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
650132
Jude
Crystal structure of F65/Y131C ...
Mus musculus
Biochemistry
41
2485-2491
2002
-
-
1
1
2
-
-
-
-
1
-
1
-
6
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
2
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
650139
An
Chemical rescue in catalysis b ...
Homo sapiens
Biochemistry
41
3235-3242
2002
-
-
1
1
4
-
-
-
-
-
-
1
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
4
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
650162
Ferraroni
Crystal structure of a zinc-ac ...
Homo sapiens
Biochemistry
41
6237-6244
2002
-
-
1
1
1
-
-
-
-
1
1
1
-
2
-
-
1
-
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
1
-
-
-
-
-
-
1
1
1
-
-
-
1
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
650163
Tripp
Role of the arginine 59 in the ...
Methanosarcina thermophila
Biochemistry
41
669-678
2002
-
-
1
-
7
1
-
27
-
1
2
1
-
2
-
-
1
-
-
-
-
-
1
1
-
-
-
28
-
-
-
-
-
-
-
-
-
1
-
-
7
1
-
-
-
27
-
1
2
1
-
-
-
1
-
-
-
-
1
1
-
-
-
28
-
-
-
-
-
-
-
-
-
-
650271
Arslan
-
Synthesis of new sulfonamide i ...
Homo sapiens
Biochemistry (Moscow)
67
1273-1276
2002
-
-
-
-
-
-
5
-
-
1
-
1
-
1
-
-
1
-
-
2
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
1
-
1
-
-
-
1
-
2
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
650363
Sandor
Effect of lecithin and MgCO3 a ...
Bos taurus
Biochim. Biophys. Acta
1570
63-74
2002
-
-
-
-
-
-
-
-
-
1
1
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
650522
Buelbuel
Bile acid derivatives of 5-ami ...
Homo sapiens
Bioorg. Med. Chem.
10
2561-2567
2002
-
-
-
-
-
-
10
-
-
1
-
1
-
3
-
-
1
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
10
-
-
-
1
-
1
-
-
-
1
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
651303
Alam
The importance of being knotte ...
Bos taurus
FEBS Lett.
519
35-40
2002
-
-
1
-
1
-
1
-
-
-
-
1
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
651703
Smith
Roles of the conserved asparta ...
Methanothermobacter thermautotrophicus
J. Bacteriol.
184
4240-4245
2002
-
-
1
-
5
-
-
13
-
1
-
1
-
3
-
-
1
-
-
-
-
-
1
-
-
-
-
14
-
1
-
-
-
-
-
-
-
1
-
-
5
-
-
-
-
13
-
1
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
14
-
1
-
-
-
-
-
-
-
-
652310
Tu
Kinetic analysis of multiple p ...
Homo sapiens
J. Biol. Chem.
277
38870-38876
2002
-
-
-
1
11
-
-
-
-
1
-
1
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
1
11
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
652737
Abbate
Nonaromatic sulfonamide group ...
Homo sapiens
J. Med. Chem.
45
3583-3587
2002
-
1
-
1
-
-
3
-
-
1
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
3
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
653677
Slaymaker
The tobacco salicylic acid-bin ...
Nicotiana tabacum
Proc. Natl. Acad. Sci. USA
99
11640-11645
2002
-
-
1
-
-
-
-
-
2
1
2
1
-
3
-
-
1
-
-
1
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
1
2
1
-
-
-
1
-
1
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
649577
Wingo
The catalytic properties of hu ...
Homo sapiens
Biochem. Biophys. Res. Commun.
288
666-669
2001
-
-
1
-
-
-
5
-
1
1
-
1
-
3
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
3
-
-
-
-
1
-
-
-
-
-
5
3
-
1
1
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
650048
Duda
Structural and kinetic analysi ...
Homo sapiens
Biochemistry
40
1741-1748
2001
-
-
1
1
1
-
-
-
-
1
-
1
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
1
1
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
650062
DiTusa
Thermodynamics of metal ion bi ...
Homo sapiens
Biochemistry
40
5338-5344
2001
-
-
1
1
-
-
-
-
-
3
-
1
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
3
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
650063
DiTusa
Thermodynamics of metal ion bi ...
Homo sapiens
Biochemistry
40
5345-5351
2001
-
-
1
-
5
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
5
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
650269
Arslan
Inhibition of bovine carbonic ...
Bos taurus
Biochemistry (Moscow)
66
982-983
2001
-
-
-
-
-
-
3
-
-
-
-
1
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
650349
Chirica
Cloning, expression and some p ...
Helicobacter pylori
Biochim. Biophys. Acta
1544
55-63
2001
-
-
1
-
-
1
2
1
-
1
2
1
-
6
-
-
1
-
-
-
-
-
3
-
-
-
-
1
1
1
-
-
1
2
-
-
-
1
-
-
-
1
-
2
1
1
-
1
2
1
-
-
-
1
-
-
-
-
3
-
-
-
-
1
1
1
-
2
-
-
-
-
-
-
651093
Elleby
Characterization of carbonic a ...
Neisseria gonorrhoeae
Eur. J. Biochem.
268
1613-1619
2001
-
-
1
-
1
1
6
-
-
2
-
1
-
3
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
6
-
-
-
-
1
-
-
1
1
-
6
6
-
-
2
-
1
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
651575
Tu
Bicarbonate as a proton donor ...
Homo sapiens, Methanosarcina thermophila
J. Am. Chem. Soc.
123
5861-5866
2001
-
-
2
1
1
-
-
-
-
3
-
2
-
5
-
-
2
-
-
-
-
-
2
-
-
-
-
-
2
1
-
-
-
-
-
-
-
2
-
1
1
-
-
-
-
-
-
3
-
2
-
-
-
2
-
-
-
-
2
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
652094
Strop
Crystal structure of the 'cab' ...
Methanothermobacter thermautotrophicus
J. Biol. Chem.
276
10299-10305
2001
-
-
1
1
-
-
-
-
-
1
-
1
-
3
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
652635
Casini
Carbonic anhydrase inhibitors: ...
Bos taurus
J. Enzyme Inhib.
16
113-123
2001
-
-
1
-
-
-
10
-
1
-
-
1
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
10
-
-
1
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
652636
Chazalette
Carbonic anhydrase inhibitors, ...
Homo sapiens
J. Enzyme Inhib.
16
125-133
2001
-
-
1
-
-
-
10
-
-
1
-
1
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
10
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
652638
Chazalette
Carbonic anhydrase inhibitors: ...
Homo sapiens
J. Enzyme Inhib.
16
475-489
2001
-
-
1
-
-
-
25
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
25
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
652639
Ul-Hassan
Carbonic anhydrase inhibitors: ...
Bos taurus, Homo sapiens
J. Enzyme Inhib.
16
499-505
2001
-
-
2
-
-
-
24
-
1
2
-
2
-
2
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
36
-
-
-
-
2
-
-
-
-
-
24
36
-
1
2
-
2
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
652647
Maffia
Carbonic anhydrase activity in ...
Anguilla anguilla, Chionodraco hamatus, Trematomus bernacchii
J. Exp. Biol.
204
3983-3992
2001
-
-
-
-
-
-
6
3
3
3
3
3
-
6
-
-
3
-
-
24
3
-
3
-
-
-
3
4
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
6
6
3
3
3
3
3
-
-
-
3
-
24
3
-
3
-
-
-
3
4
-
-
-
-
-
-
-
-
-
-
653657
Karhumaa
The identification of secreted ...
Homo sapiens, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Proc. Natl. Acad. Sci. USA
98
11604-11608
2001
-
-
-
-
-
-
-
-
-
2
2
3
-
164
-
2
2
-
-
5
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
3
-
-
2
2
-
5
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
653675
Whittington
Crystal structure of the dimer ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
98
9545-9550
2001
-
-
1
1
-
-
1
-
2
1
3
1
-
2
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
2
1
3
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
653792
Cronk
Crystal structure of E. coli b ...
Escherichia coli
Protein Sci.
10
911-922
2001
-
-
1
1
-
-
-
-
-
1
-
1
-
8
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
649114
Cronk
-
Cloning, crystallization and p ...
Escherichia coli
Acta Crystallogr. Sect. D
56
1176-1179
2000
-
-
1
1
-
-
-
-
-
1
2
1
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
2
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
649925
Cox
The active site structure of T ...
Conticribra weissflogii
Biochemistry
39
12128-12130
2000
-
-
-
1
-
-
-
-
-
1
1
1
-
5
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
1
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
649927
Guerri
Mechanism of cyanamide hydrati ...
Homo sapiens
Biochemistry
39
12391-12397
2000
-
-
1
1
-
-
-
-
-
1
1
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
650006
Iverson
A closer look at the active si ...
Methanosarcina thermophila
Biochemistry
39
9222-9231
2000
-
-
1
1
-
-
-
-
-
2
-
1
-
3
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
650007
Tripp
A structure-function study of ...
Methanosarcina thermophila
Biochemistry
39
9232-9240
2000
-
-
1
-
19
-
-
29
-
1
2
1
-
2
-
-
1
-
-
-
-
-