Protein Variants | Comment | Organism |
---|---|---|
L204S | affinity for sulfonamides/sulfamate inhibitor is moderately decreased compared to wild-type. kcat and Km (CO2) comparable to wild-type | Homo sapiens |
N67I | affinity for sulfonamides/sulfamate inhibitor is highly decreased compared to wild-type. kcat and Km (CO2) comparable to wild-type | Homo sapiens |
Q92V | affinity for sulfonamides/sulfamate inhibitor is decreased compared to wild-type. kcat and Km (CO2) comparable to wild-type | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(1,2-benzoxazol-3-yl)methanesulfonamide | - |
Homo sapiens | |
2-amino-1-benzothiophen-3(2H)-one 1,1-dioxide | - |
Homo sapiens | |
4-(2-aminoethyl)benzenesulfonamide | - |
Homo sapiens | |
4-(2-hydroxyethyl)benzenesulfonamide | - |
Homo sapiens | |
4-amino-3-fluorobenzenesulfonamide | - |
Homo sapiens | |
4-amino-6-chlorobenzene-1,3-disulfonamide | - |
Homo sapiens | |
4-Aminobenzenesulfonamide | - |
Homo sapiens | |
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide | - |
Homo sapiens | |
5-(formylamino)-1,3,4-thiadiazole-2-sulfonamide | - |
Homo sapiens | |
5-amino-1,3,4-thiadiazole-2-sulfonamide | - |
Homo sapiens | |
6-ethoxy-1,3-benzothiazole-2-sulfonamide | - |
Homo sapiens | |
[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
9 | - |
CO2 | pH 7.5, 20°C, mutant N67I | Homo sapiens | |
9.2 | - |
CO2 | pH 7.5, 20°C, mutant Q92V | Homo sapiens | |
9.3 | - |
CO2 | pH 7.5, 20°C, wild-type | Homo sapiens | |
9.3 | - |
CO2 | pH 7.5, 20°C, mutant L204S | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CO2 + H2O | - |
Homo sapiens | H2CO3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
hCAII | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
20 | - |
assay at | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1000000 | - |
CO2 | pH 7.5, 20°C, mutant Q92V | Homo sapiens | |
1400000 | - |
CO2 | pH 7.5, 20°C, wild-type | Homo sapiens | |
1400000 | - |
CO2 | pH 7.5, 20°C, mutant N67I | Homo sapiens | |
1500000 | - |
CO2 | pH 7.5, 20°C, mutant L204S | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000008 | - |
6-ethoxy-1,3-benzothiazole-2-sulfonamide | wild-type, pH 7.5, 20°C | Homo sapiens | |
0.00001 | - |
[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate | wild-type, pH 7.5, 20°C | Homo sapiens | |
0.000012 | - |
5-(formylamino)-1,3,4-thiadiazole-2-sulfonamide | wild-type, pH 7.5, 20°C | Homo sapiens | |
0.000021 | - |
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide | wild-type, pH 7.5, 20°C | Homo sapiens | |
0.000035 | - |
1-(1,2-benzoxazol-3-yl)methanesulfonamide | wild-type, pH 7.5, 20°C | Homo sapiens | |
0.00006 | - |
5-amino-1,3,4-thiadiazole-2-sulfonamide | wild-type, pH 7.5, 20°C | Homo sapiens | |
0.00006 | - |
4-amino-3-fluorobenzenesulfonamide | wild-type, pH 7.5, 20°C | Homo sapiens | |
0.000075 | - |
4-amino-6-chlorobenzene-1,3-disulfonamide | wild-type, pH 7.5, 20°C | Homo sapiens | |
0.000125 | - |
4-(2-hydroxyethyl)benzenesulfonamide | wild-type, pH 7.5, 20°C | Homo sapiens | |
0.00016 | - |
4-(2-aminoethyl)benzenesulfonamide | wild-type, pH 7.5, 20°C | Homo sapiens | |
0.00024 | - |
4-Aminobenzenesulfonamide | wild-type, pH 7.5, 20°C | Homo sapiens | |
0.00595 | - |
2-amino-1-benzothiophen-3(2H)-one 1,1-dioxide | wild-type, pH 7.5, 20°C | Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
108000 | - |
CO2 | pH 7.5, 20°C, mutant Q92V | Homo sapiens | |
150000 | - |
CO2 | pH 7.5, 20°C, wild-type | Homo sapiens | |
155000 | - |
CO2 | pH 7.5, 20°C, mutant N67I | Homo sapiens | |
161000 | - |
CO2 | pH 7.5, 20°C, mutant L204S | Homo sapiens |