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Literature summary for 4.2.1.1 extracted from

  • Kolayli, S.; Karahalil, F.; Sahin, H.; Dincer, B.; Supuran, C.T.
    Characterization and inhibition studies of an alpha-carbonic anhydrase from the endangered sturgeon species Acipenser gueldenstaedti (2011), J. Enzyme Inhib. Med. Chem., 26, 895-900.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2,4-Dichlorophenol
-
Acipenser gueldenstaedtii
acetazolamide strong inhibition Acipenser gueldenstaedtii
Ag+ weak inhibition Acipenser gueldenstaedtii
Carbaryl
-
Acipenser gueldenstaedtii
Co2+ weak inhibition Acipenser gueldenstaedtii
Cu2+ weak inhibition Acipenser gueldenstaedtii
maneb
-
Acipenser gueldenstaedtii
parathion
-
Acipenser gueldenstaedtii
propineb
-
Acipenser gueldenstaedtii
sulphanilamide strong inhibition Acipenser gueldenstaedtii
Zn2+ weak inhibition Acipenser gueldenstaedtii

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information Km is 4.0 mM with 4-nitrophenyl acetate, pH 9.0, 30°C, esterase activity Acipenser gueldenstaedtii
10.9
-
CO2 pH 7.4, 30°C, CO2 hydration activity Acipenser gueldenstaedtii

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
29000
-
x * 29000, SDS-PAGE Acipenser gueldenstaedtii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
H2CO3 Acipenser gueldenstaedtii
-
CO2 + H2O
-
r

Organism

Organism UniProt Comment Textmining
Acipenser gueldenstaedtii
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme 539fold by one-step affinity chromatography on L-tyrosine sulphonamide Acipenser gueldenstaedtii

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Acipenser gueldenstaedtii
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
26970
-
purified native enzyme, pH 7.4, 30°C Acipenser gueldenstaedtii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H2CO3
-
Acipenser gueldenstaedtii CO2 + H2O
-
r
additional information the enzyme shows esterase activity with 4-nitrophenyl acetate Acipenser gueldenstaedtii ?
-
?

Subunits

Subunits Comment Organism
? x * 29000, SDS-PAGE Acipenser gueldenstaedtii

Synonyms

Synonyms Comment Organism
alpha-carbonic anhydrase
-
Acipenser gueldenstaedtii
CO2 hydrase
-
Acipenser gueldenstaedtii

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Acipenser gueldenstaedtii

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
additional information 20.3/s with 4-nitrophenyl acetate, pH 9.0, 30°C, esterase activity Acipenser gueldenstaedtii
1200000
-
CO2 pH 7.4, 30°C, CO2 hydration activity Acipenser gueldenstaedtii

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Acipenser gueldenstaedtii

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000026
-
acetazolamide pH 7.4, 30°C, inhibition of CO2 hydration activity Acipenser gueldenstaedtii
0.00005
-
acetazolamide pH 9.0, 30°C, inhibition of esterase activity with 4-nitrophenyl acetate Acipenser gueldenstaedtii

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0001
-
pH 7.4, 30°C, inhibition of CO2 hydration activity Acipenser gueldenstaedtii acetazolamide
0.004
-
pH 7.4, 30°C, inhibition of CO2 hydration activity Acipenser gueldenstaedtii sulphanilamide
0.016
-
pH 7.4, 30°C, inhibition of CO2 hydration activity Acipenser gueldenstaedtii propineb
0.018
-
pH 7.4, 30°C, inhibition of CO2 hydration activity Acipenser gueldenstaedtii maneb
0.102
-
pH 7.4, 30°C, inhibition of CO2 hydration activity Acipenser gueldenstaedtii parathion
0.24
-
pH 7.4, 30°C, inhibition of CO2 hydration activity Acipenser gueldenstaedtii 2,4-Dichlorophenol
0.398
-
pH 7.4, 30°C, inhibition of CO2 hydration activity Acipenser gueldenstaedtii Carbaryl
1.7
-
pH 7.4, 30°C, inhibition of CO2 hydration activity Acipenser gueldenstaedtii Ag+
2.8
-
pH 7.4, 30°C, inhibition of CO2 hydration activity Acipenser gueldenstaedtii Zn2+
3
-
pH 7.4, 30°C, inhibition of CO2 hydration activity Acipenser gueldenstaedtii Co2+
5.2
-
pH 7.4, 30°C, inhibition of CO2 hydration activity Acipenser gueldenstaedtii Cu2+

General Information

General Information Comment Organism
additional information the wide use of dithiocarbamate pesticides may be one of the factors enhancing the vulnerability of this sturgeon species to pollutants, since they act as effective carbonate dehydratase inhibitors Acipenser gueldenstaedtii