Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,2,4-trimethoxybenzene | - |
Homo sapiens | |
1,2-dimethoxybenzene | - |
Homo sapiens | |
1,4-dimethoxybenzene | - |
Homo sapiens | |
2,6-dimethoxybenzoic acid | - |
Homo sapiens | |
3,4-dihydroxybenzoic acid | - |
Homo sapiens | |
3,4-dimethoxybenzoic acid | - |
Homo sapiens | |
3,5-Dihydroxybenzoic acid | - |
Homo sapiens | |
3-Hydroxybenzoic acid | - |
Homo sapiens | |
5-amino-1,3,4-thiadiazole-2-sulfonamide | - |
Homo sapiens | |
coumarin | - |
Homo sapiens | |
additional information | carbonic anhydrases are inhibited by sulfonamides, inorganic anions, phenols, coumarins (acting as prodrugs) and polyamines. Development of hydroxy-, methoxy-substituted benzoic acids as well as di-, tri-methoxy benzenes as submicromolar-low micromolar inhibitors of carbonic anhydrase isozymes, molecular docking and inhibition mechanism, overview | Homo sapiens | |
phenol | - |
Homo sapiens | |
spermine | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | isozymes I and II | Homo sapiens | 5829 | - |
membrane | transmembrane isozymes IX and XII | Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
H2CO3 | Homo sapiens | - |
CO2 + H2O | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes I, II, IX and XII | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | cancer-associated cell, isozymes IX and XII | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
H2CO3 | - |
Homo sapiens | CO2 + H2O | - |
r |
Synonyms | Comment | Organism |
---|---|---|
carbonic anhydrase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000033 | - |
5-amino-1,3,4-thiadiazole-2-sulfonamide | isozyme hCAXII, pH 7.5, 22°C | Homo sapiens | |
0.000041 | - |
5-amino-1,3,4-thiadiazole-2-sulfonamide | isozyme hCAIX, pH 7.5, 22°C | Homo sapiens | |
0.00006 | - |
5-amino-1,3,4-thiadiazole-2-sulfonamide | isozyme hCAII, pH 7.5, 22°C | Homo sapiens | |
0.000353 | - |
3-Hydroxybenzoic acid | isozyme hCAXII, pH 7.5, 22°C | Homo sapiens | |
0.000367 | - |
3,5-Dihydroxybenzoic acid | isozyme hCAXII, pH 7.5, 22°C | Homo sapiens | |
0.00047 | - |
3,4-dihydroxybenzoic acid | isozyme hCAII, pH 7.5, 22°C | Homo sapiens | |
0.0005 | - |
1,2-dimethoxybenzene | isozyme hCAII, pH 7.5, 22°C | Homo sapiens | |
0.00051 | - |
3,5-Dihydroxybenzoic acid | isozyme hCAII, pH 7.5, 22°C | Homo sapiens | |
0.00055 | - |
3,5-Dihydroxybenzoic acid | isozyme hCAI, pH 7.5, 22°C | Homo sapiens | |
0.0006 | - |
3-Hydroxybenzoic acid | isozyme hCAII, pH 7.5, 22°C | Homo sapiens | |
0.000823 | - |
2,6-dimethoxybenzoic acid | isozyme hCAXII, pH 7.5, 22°C | Homo sapiens | |
0.00102 | - |
2,6-dimethoxybenzoic acid | isozyme hCAII, pH 7.5, 22°C | Homo sapiens | |
0.00143 | - |
1,2,4-trimethoxybenzene | isozyme hCAII, pH 7.5, 22°C | Homo sapiens | |
0.0018 | - |
3,4-dihydroxybenzoic acid | isozyme hCAI, pH 7.5, 22°C | Homo sapiens | |
0.00237 | - |
3-Hydroxybenzoic acid | isozyme hCAI, pH 7.5, 22°C | Homo sapiens | |
0.0031 | - |
coumarin | isozyme hCAI, pH 7.5, 22°C | Homo sapiens | |
0.00335 | - |
1,4-dimethoxybenzene | isozyme hCAII, pH 7.5, 22°C | Homo sapiens | |
0.00402 | - |
1,4-dimethoxybenzene | isozyme hCAXII, pH 7.5, 22°C | Homo sapiens | |
0.00406 | - |
1,2,4-trimethoxybenzene | isozyme hCAIX, pH 7.5, 22°C | Homo sapiens | |
0.00409 | - |
3,4-dihydroxybenzoic acid | isozyme hCAXII, pH 7.5, 22°C | Homo sapiens | |
0.00415 | - |
1,4-dimethoxybenzene | isozyme hCAIX, pH 7.5, 22°C | Homo sapiens | |
0.00441 | - |
3,5-Dihydroxybenzoic acid | isozyme hCAIX, pH 7.5, 22°C | Homo sapiens | |
0.00445 | - |
3,4-dihydroxybenzoic acid | isozyme hCAIX, pH 7.5, 22°C | Homo sapiens | |
0.00453 | - |
3-Hydroxybenzoic acid | isozyme hCAIX, pH 7.5, 22°C | Homo sapiens | |
0.0055 | - |
phenol | isozyme hCAII, pH 7.5, 22°C | Homo sapiens | |
0.00596 | - |
1,2,4-trimethoxybenzene | isozyme hCAI, pH 7.5, 22°C | Homo sapiens | |
0.00618 | - |
3,4-dimethoxybenzoic acid | isozyme hCAII, pH 7.5, 22°C | Homo sapiens | |
0.0067 | - |
3,4-dimethoxybenzoic acid | isozyme hCAXII, pH 7.5, 22°C | Homo sapiens | |
0.00683 | - |
3,4-dimethoxybenzoic acid | isozyme hCAI, pH 7.5, 22°C | Homo sapiens | |
0.0078 | - |
1,2,4-trimethoxybenzene | isozyme hCAXII, pH 7.5, 22°C | Homo sapiens | |
0.00821 | - |
1,4-dimethoxybenzene | isozyme hCAI, pH 7.5, 22°C | Homo sapiens | |
0.00825 | - |
3,4-dimethoxybenzoic acid | isozyme hCAIX, pH 7.5, 22°C | Homo sapiens | |
0.00836 | - |
1,2-dimethoxybenzene | isozyme hCAXII, pH 7.5, 22°C | Homo sapiens | |
0.0086 | - |
5-amino-1,3,4-thiadiazole-2-sulfonamide | isozyme hCAI, pH 7.5, 22°C | Homo sapiens | |
0.00863 | - |
1,2-dimethoxybenzene | isozyme hCAIX, pH 7.5, 22°C | Homo sapiens | |
0.0088 | - |
phenol | isozyme hCAIX, pH 7.5, 22°C | Homo sapiens | |
0.00907 | - |
2,6-dimethoxybenzoic acid | isozyme hCAIX, pH 7.5, 22°C | Homo sapiens | |
0.0092 | - |
coumarin | isozyme hCAII, pH 7.5, 22°C | Homo sapiens | |
0.0092 | - |
phenol | isozyme hCAXII, pH 7.5, 22°C | Homo sapiens | |
0.00967 | - |
2,6-dimethoxybenzoic acid | isozyme hCAI, pH 7.5, 22°C | Homo sapiens | |
0.0102 | - |
phenol | isozyme hCAI, pH 7.5, 22°C | Homo sapiens | |
0.0104 | - |
1,2-dimethoxybenzene | isozyme hCAI, pH 7.5, 22°C | Homo sapiens | |
0.0133 | - |
spermine | isozyme hCAIX, pH 7.5, 22°C | Homo sapiens | |
0.0276 | - |
spermine | isozyme hCAXII, pH 7.5, 22°C | Homo sapiens | |
0.084 | - |
spermine | isozyme hCAII, pH 7.5, 22°C | Homo sapiens | |
0.231 | - |
spermine | isozyme hCAI, pH 7.5, 22°C | Homo sapiens | |
1 | - |
coumarin | above, isozyme hCAIX, pH 7.5, 22°C | Homo sapiens | |
1 | - |
coumarin | above, isozyme hCAXII, pH 7.5, 22°C | Homo sapiens |