Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3aR,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl sulfamate | - |
Homo sapiens | |
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-galactopyranosylamine | - |
Homo sapiens | |
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-glucopyranosylamine | - |
Homo sapiens | |
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-mannopyranosylamine | - |
Homo sapiens | |
2,3,4-tri-O-acetyl-6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine | - |
Homo sapiens | |
3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-arabino-hexopyranosylamine | - |
Homo sapiens | |
3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-lyxo-hexopyranosylamine | - |
Homo sapiens | |
6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine | - |
Homo sapiens | |
additional information | N-beta-glycosyl sulfamides are selective inhibitors of the cancer-associated carbonic anhydrase isoforms IX and XII | Homo sapiens | |
N-sulfamoyl-beta-D-galactopyranosylamine | - |
Homo sapiens | |
N-sulfamoyl-beta-D-glucopyranosylamine | - |
Homo sapiens | |
N-sulfamoyl-beta-D-mannopyranosylamine | - |
Homo sapiens | |
N-[(3aR,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]sulfamic amide | - |
Homo sapiens | |
topiramate | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | cytosolic isozymes hCA I and hCA II | Homo sapiens | 5829 | - |
membrane | transmembrane isozymes hCA IX and hCA XII | Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | required | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
carbonic anhydrase | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000038 | - |
(3aR,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl sulfamate | isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000048 | - |
3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-arabino-hexopyranosylamine | isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.000005 | - |
(3aR,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl sulfamate | isozyme hCA II, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.000005 | - |
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-mannopyranosylamine | isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000053 | - |
2,3,4-tri-O-acetyl-6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine | isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000054 | - |
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-glucopyranosylamine | isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000056 | - |
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-mannopyranosylamine | isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000058 | - |
2,3,4-tri-O-acetyl-6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine | isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000065 | - |
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-galactopyranosylamine | isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000072 | - |
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-galactopyranosylamine | isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000077 | - |
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-glucopyranosylamine | isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000078 | - |
3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-lyxo-hexopyranosylamine | isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.000011 | - |
3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-lyxo-hexopyranosylamine | isozyme hCA II, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.000012 | - |
3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-arabino-hexopyranosylamine | isozyme hCA II, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.000013 | - |
3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-arabino-hexopyranosylamine | isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.000016 | - |
3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-lyxo-hexopyranosylamine | isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.000058 | - |
(3aR,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl sulfamate | isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.000076 | - |
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-galactopyranosylamine | isozyme hCA II, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.000081 | - |
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-glucopyranosylamine | isozyme hCA II, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.000082 | - |
2,3,4-tri-O-acetyl-6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine | isozyme hCA II, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.000085 | - |
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-mannopyranosylamine | isozyme hCA II, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.00025 | - |
(3aR,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl sulfamate | isozyme hCA I, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.00083 | - |
3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-arabino-hexopyranosylamine | isozyme hCA I, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.00083 | - |
3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-lyxo-hexopyranosylamine | isozyme hCA I, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.00094 | - |
N-sulfamoyl-beta-D-galactopyranosylamine | isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.00179 | - |
N-sulfamoyl-beta-D-mannopyranosylamine | isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.001875 | - |
N-[(3aR,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]sulfamic amide | isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.00197 | - |
N-sulfamoyl-beta-D-glucopyranosylamine | isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.002135 | - |
N-[(3aR,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]sulfamic amide | isozyme hCA II, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.00314 | - |
6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine | isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.00345 | - |
N-[(3aR,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]sulfamic amide | isozyme hCA I, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.003714 | - |
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-glucopyranosylamine | isozyme hCA I, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.00458 | - |
N-[(3aR,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]sulfamic amide | isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.00468 | - |
N-sulfamoyl-beta-D-glucopyranosylamine | isozyme hCA II, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.00544 | - |
N-sulfamoyl-beta-D-mannopyranosylamine | isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.00647 | - |
N-sulfamoyl-beta-D-glucopyranosylamine | isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.00823 | - |
N-sulfamoyl-beta-D-galactopyranosylamine | isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.008637 | - |
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-galactopyranosylamine | isozyme hCA I, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.00953 | - |
2,3,4-tri-O-acetyl-6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine | isozyme hCA I, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.009703 | - |
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-mannopyranosylamine | isozyme hCA I, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0099 | - |
6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine | isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0212 | - |
N-sulfamoyl-beta-D-mannopyranosylamine | isozyme hCA II, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0223 | - |
6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine | isozyme hCA II, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0485 | - |
N-sulfamoyl-beta-D-galactopyranosylamine | isozyme hCA II, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0658 | - |
N-sulfamoyl-beta-D-galactopyranosylamine | isozyme hCA I, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0754 | - |
N-sulfamoyl-beta-D-glucopyranosylamine | isozyme hCA I, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0919 | - |
N-sulfamoyl-beta-D-mannopyranosylamine | isozyme hCA I, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.5 | - |
6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine | above, isozyme hCA I, pH not specified in the publication, temperature not specified in the publication | Homo sapiens |