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Literature summary for 4.2.1.1 extracted from

  • Rodriguez, O.M.; Maresca, A.; Tempera, C.A.; Bravo, R.D.; Colinas, P.A.; Supuran, C.T.
    N-beta-Glycosyl sulfamides are selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII (2011), Bioorg. Med. Chem. Lett., 21, 4447-4450.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(3aR,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl sulfamate
-
Homo sapiens
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-galactopyranosylamine
-
Homo sapiens
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-glucopyranosylamine
-
Homo sapiens
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-mannopyranosylamine
-
Homo sapiens
2,3,4-tri-O-acetyl-6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine
-
Homo sapiens
3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-arabino-hexopyranosylamine
-
Homo sapiens
3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-lyxo-hexopyranosylamine
-
Homo sapiens
6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine
-
Homo sapiens
additional information N-beta-glycosyl sulfamides are selective inhibitors of the cancer-associated carbonic anhydrase isoforms IX and XII Homo sapiens
N-sulfamoyl-beta-D-galactopyranosylamine
-
Homo sapiens
N-sulfamoyl-beta-D-glucopyranosylamine
-
Homo sapiens
N-sulfamoyl-beta-D-mannopyranosylamine
-
Homo sapiens
N-[(3aR,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]sulfamic amide
-
Homo sapiens
topiramate
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol cytosolic isozymes hCA I and hCA II Homo sapiens 5829
-
membrane transmembrane isozymes hCA IX and hCA XII Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ required Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
carbonic anhydrase
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000038
-
(3aR,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl sulfamate isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0000048
-
3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-arabino-hexopyranosylamine isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.000005
-
(3aR,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl sulfamate isozyme hCA II, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.000005
-
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-mannopyranosylamine isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0000053
-
2,3,4-tri-O-acetyl-6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0000054
-
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-glucopyranosylamine isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0000056
-
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-mannopyranosylamine isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0000058
-
2,3,4-tri-O-acetyl-6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0000065
-
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-galactopyranosylamine isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0000072
-
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-galactopyranosylamine isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0000077
-
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-glucopyranosylamine isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0000078
-
3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-lyxo-hexopyranosylamine isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.000011
-
3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-lyxo-hexopyranosylamine isozyme hCA II, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.000012
-
3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-arabino-hexopyranosylamine isozyme hCA II, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.000013
-
3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-arabino-hexopyranosylamine isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.000016
-
3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-lyxo-hexopyranosylamine isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.000058
-
(3aR,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl sulfamate isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.000076
-
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-galactopyranosylamine isozyme hCA II, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.000081
-
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-glucopyranosylamine isozyme hCA II, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.000082
-
2,3,4-tri-O-acetyl-6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine isozyme hCA II, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.000085
-
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-mannopyranosylamine isozyme hCA II, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.00025
-
(3aR,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl sulfamate isozyme hCA I, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.00083
-
3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-arabino-hexopyranosylamine isozyme hCA I, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.00083
-
3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-lyxo-hexopyranosylamine isozyme hCA I, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.00094
-
N-sulfamoyl-beta-D-galactopyranosylamine isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.00179
-
N-sulfamoyl-beta-D-mannopyranosylamine isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.001875
-
N-[(3aR,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]sulfamic amide isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.00197
-
N-sulfamoyl-beta-D-glucopyranosylamine isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.002135
-
N-[(3aR,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]sulfamic amide isozyme hCA II, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.00314
-
6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.00345
-
N-[(3aR,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]sulfamic amide isozyme hCA I, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.003714
-
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-glucopyranosylamine isozyme hCA I, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.00458
-
N-[(3aR,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]sulfamic amide isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.00468
-
N-sulfamoyl-beta-D-glucopyranosylamine isozyme hCA II, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.00544
-
N-sulfamoyl-beta-D-mannopyranosylamine isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.00647
-
N-sulfamoyl-beta-D-glucopyranosylamine isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.00823
-
N-sulfamoyl-beta-D-galactopyranosylamine isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.008637
-
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-galactopyranosylamine isozyme hCA I, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.00953
-
2,3,4-tri-O-acetyl-6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine isozyme hCA I, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.009703
-
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-mannopyranosylamine isozyme hCA I, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0099
-
6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0212
-
N-sulfamoyl-beta-D-mannopyranosylamine isozyme hCA II, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0223
-
6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine isozyme hCA II, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0485
-
N-sulfamoyl-beta-D-galactopyranosylamine isozyme hCA II, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0658
-
N-sulfamoyl-beta-D-galactopyranosylamine isozyme hCA I, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0754
-
N-sulfamoyl-beta-D-glucopyranosylamine isozyme hCA I, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0919
-
N-sulfamoyl-beta-D-mannopyranosylamine isozyme hCA I, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.5
-
6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine above, isozyme hCA I, pH not specified in the publication, temperature not specified in the publication Homo sapiens