Literature summary for 4.2.1.1 extracted from

Alterio, V.; Hilvo, M.; Di Fiore, A.; Supuran, C.T.; Pan, P.; Parkkila, S.; Scaloni, A.; Pastorek, J.; Pastorekova, S.; Pedone, C.; Scozzafava, A.; Monti, S.M.; De Simone, G.
Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX (2009), Proc. Natl. Acad. Sci. USA, 106, 16233-16238.

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Application

Application	Comment	Organism
medicine	CA IX is a marker of tumor hypoxia and a prognostic factor in several human cancers, inhibition of this enzyme shows antitumor activity both in vitro and in vivo	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
using the baculovirusinsect cell expression system	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging drop vapor diffusion method, using 0.4 M NH4H2PO4, 0.1 M sodium citrate, pH 5.0	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
plasma membrane	-	Homo sapiens	5886	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q16790	-	-

Purification (Commentary)

Purification (Comment)	Organism
Superdex 200 gel filtration and Superdex 75 gel filtration	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CO2 + H2O	-	Homo sapiens	H2CO3	-	r

Synonyms

Synonyms	Comment	Organism
CA IX	-	Homo sapiens
carbonic anhydrase IX	-	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6.5	-	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	CA IX is involved in solid tumor acidification	Homo sapiens

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Release 2023.1 (January 2023)