Literature summary for 4.2.1.1 extracted from

Bertucci, A.; Innocenti, A.; Zoccola, D.; Scozzafava, A.; Tambutte, S.; Supuran, C.T.
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides (2009), Bioorg. Med. Chem., 17, 5054-5058.

Inhibitors

Inhibitors	Comment	Organism
2-aminobenzenesulfonamide	-	Stylophora pistillata
2-hydrazinylbenzenesulfonamide	-	Stylophora pistillata
3-(4-sulfamoylphenyl)propanoic acid	-	Stylophora pistillata
4-(2-aminoethyl)benzenesulfonamide	-	Stylophora pistillata
4-(2-hydroxyethyl)benzenesulfonamide	-	Stylophora pistillata
4-(aminomethyl)benzenesulfonamide	-	Stylophora pistillata
4-(hydroxymethyl)benzenesulfonamide	-	Stylophora pistillata
4-amino-3-bromobenzenesulfonamide	-	Stylophora pistillata
4-amino-3-chlorobenzenesulfonamide	-	Stylophora pistillata
4-amino-3-fluorobenzenesulfonamide	-	Stylophora pistillata
4-amino-3-iodobenzenesulfonamide	-	Stylophora pistillata
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide	-	Stylophora pistillata
4-amino-6-chlorobenzene-1,3-disulfonamide	-	Stylophora pistillata
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide	-	Stylophora pistillata
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide	-	Stylophora pistillata
4-Aminobenzenesulfonamide	-	Stylophora pistillata
4-methylbenzenesulfonamide	-	Stylophora pistillata
4-sulfamoylbenzoic acid	-	Stylophora pistillata
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide	-	Stylophora pistillata
5-amino-1,3,4-thiadiazole-2-sulfonamide	-	Stylophora pistillata
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide	-	Stylophora pistillata
5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide	-	Stylophora pistillata
acetazolamide	-	Stylophora pistillata
benzolamide	-	Stylophora pistillata
brinzolamide	-	Stylophora pistillata
celecoxib	-	Stylophora pistillata
dichlorophenamide	-	Stylophora pistillata
dorzolamide	-	Stylophora pistillata
ethoxzolamide	-	Stylophora pistillata
indisulam	-	Stylophora pistillata
methazolamide	-	Stylophora pistillata
saccharin	effective STPCA inhibitor	Stylophora pistillata
sulpiride	-	Stylophora pistillata
sulthiame	-	Stylophora pistillata
topiramate	-	Stylophora pistillata
valdecoxib	-	Stylophora pistillata
zonisamide	-	Stylophora pistillata

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
CO2 + H2O	Stylophora pistillata	-	H2CO3	-	r

Organism

Organism	UniProt	Comment	Textmining
Stylophora pistillata	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CO2 + H2O	-	Stylophora pistillata	H2CO3	-	r

Synonyms

Synonyms	Comment	Organism
carbonic anhydrase	-	Stylophora pistillata
STPCA	-	Stylophora pistillata

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism
0.000016	-	acetazolamide	in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C	Stylophora pistillata
0.0000181	-	dorzolamide	in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C	Stylophora pistillata
0.0000197	-	4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide	in 10 mM HEPES (pH 7.4), at 25°C	Stylophora pistillata
0.0000204	-	benzolamide	in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C	Stylophora pistillata
0.0000212	-	methazolamide	in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C	Stylophora pistillata
0.0000254	-	4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide	in 10 mM HEPES (pH 7.4), at 25°C	Stylophora pistillata
0.0000276	-	5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide	in 10 mM HEPES (pH 7.4), at 25°C	Stylophora pistillata
0.0000287	-	valdecoxib	in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C	Stylophora pistillata
0.0000291	-	topiramate	in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C	Stylophora pistillata
0.0000298	-	4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide	in 10 mM HEPES (pH 7.4), at 25°C	Stylophora pistillata
0.0000342	-	celecoxib	in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C	Stylophora pistillata
0.0000394	-	ethoxzolamide	in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C	Stylophora pistillata
0.0000403	-	saccharin	in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C	Stylophora pistillata
0.0000452	-	sulthiame	in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C	Stylophora pistillata
0.0000482	-	brinzolamide	in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C	Stylophora pistillata
0.0000751	-	4-amino-3-fluorobenzenesulfonamide	in 10 mM HEPES (pH 7.4), at 25°C	Stylophora pistillata
0.0000825	-	4-(aminomethyl)benzenesulfonamide	in 10 mM HEPES (pH 7.4), at 25°C	Stylophora pistillata
0.0000875	-	4-amino-3-chlorobenzenesulfonamide	in 10 mM HEPES (pH 7.4), at 25°C	Stylophora pistillata
0.0000883	-	4-amino-3-iodobenzenesulfonamide	in 10 mM HEPES (pH 7.4), at 25°C	Stylophora pistillata
0.0000919	-	5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide	in 10 mM HEPES (pH 7.4), at 25°C	Stylophora pistillata
0.0000943	-	4-(2-aminoethyl)benzenesulfonamide	in 10 mM HEPES (pH 7.4), at 25°C	Stylophora pistillata
0.000104	-	4-amino-3-bromobenzenesulfonamide	in 10 mM HEPES (pH 7.4), at 25°C	Stylophora pistillata
0.000105	-	5-amino-1,3,4-thiadiazole-2-sulfonamide	in 10 mM HEPES (pH 7.4), at 25°C	Stylophora pistillata
0.000163	-	indisulam	in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C	Stylophora pistillata
0.000256	-	3-(4-sulfamoylphenyl)propanoic acid	in 10 mM HEPES (pH 7.4), at 25°C	Stylophora pistillata
0.000259	-	zonisamide	in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C	Stylophora pistillata
0.000295	-	4-amino-6-chlorobenzene-1,3-disulfonamide	in 10 mM HEPES (pH 7.4), at 25°C	Stylophora pistillata
0.000364	-	4-Aminobenzenesulfonamide	in 10 mM HEPES (pH 7.4), at 25°C	Stylophora pistillata
0.000367	-	4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide	in 10 mM HEPES (pH 7.4), at 25°C	Stylophora pistillata
0.00043	-	sulpiride	in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C	Stylophora pistillata
0.000431	-	dichlorophenamide	in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C	Stylophora pistillata
0.000435	-	4-sulfamoylbenzoic acid	in 10 mM HEPES (pH 7.4), at 25°C	Stylophora pistillata
0.000553	-	2-aminobenzenesulfonamide	in 10 mM HEPES (pH 7.4), at 25°C	Stylophora pistillata
0.000614	-	4-methylbenzenesulfonamide	in 10 mM HEPES (pH 7.4), at 25°C	Stylophora pistillata
0.000768	-	4-(hydroxymethyl)benzenesulfonamide	in 10 mM HEPES (pH 7.4), at 25°C	Stylophora pistillata
0.00077	-	4-(2-hydroxyethyl)benzenesulfonamide	in 10 mM HEPES (pH 7.4), at 25°C	Stylophora pistillata
0.00251	-	2-hydrazinylbenzenesulfonamide	in 10 mM HEPES (pH 7.4), at 25°C	Stylophora pistillata