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Literature summary for 4.2.1.1 extracted from

  • Innocenti, A.; Leewattanapasuk, W.; Manole, G.; Scozzafava, A.; Muehlschlegel, F.A.; Supuran, C.T.
    Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids (2010), Bioorg. Med. Chem. Lett., 20, 1701-1704.
    View publication on PubMed
Search for more literature for 4.2.1.1

Activating Compound

Activating Compound Comment Organism Structure
1-(2-aminoethyl)-piperazine activation constant of 0.0149 mM Nakaseomyces glabratus
2-(2-aminoethyl)pyridine activation constant of 0.0163 mM Nakaseomyces glabratus
2-pyridyl-methylamine activation constant of 0.015 mM Nakaseomyces glabratus
4-(2-aminoethyl)-morpholine activation constant of 0.0101 mM Nakaseomyces glabratus
4-amino-L-phenylalanine activation constant of 0.0316 mM Nakaseomyces glabratus
D-Dopa activation constant of 0.0151 mM Nakaseomyces glabratus
D-His activation constant of 0.0212 mM Nakaseomyces glabratus
D-Phe activation constant of 0.0157 mM Nakaseomyces glabratus
D-Trp activation constant of 0.0121 mM Nakaseomyces glabratus
D-Tyr best activator, activation constant of 0.0071 mM Nakaseomyces glabratus
dopamine activation constant of 0.0276 mM Nakaseomyces glabratus
histamine activation constant of 0.0274 mM Nakaseomyces glabratus
L-adrenaline activation constant of 0.0108 mM Nakaseomyces glabratus
L-Dopa activation constant of 0.0233 mM Nakaseomyces glabratus
L-His activation constant of 0.037 mM Nakaseomyces glabratus
L-Phe activation constant of 0.0241 mM Nakaseomyces glabratus
L-Trp activation constant of 0.0228 mM Nakaseomyces glabratus
L-Tyr best activator, activation constant of 0.0095 mM Nakaseomyces glabratus
serotonin activation constant of 0.0167 mM Nakaseomyces glabratus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
7.9
-
 histamine at 25°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Nakaseomyces glabratus

Organism

Organism UniProt Comment Textmining
Nakaseomyces glabratus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CO2 + H2O
-
 Nakaseomyces glabratus H2CO3
-
 r

Synonyms

Synonyms Comment Organism
beta-carbonic anhydrase
-
 Nakaseomyces glabratus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
380000
-
 histamine at 25°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Nakaseomyces glabratus
1070000
-
 histamine at 25°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4, in the presence of 0.01 mM histamine Nakaseomyces glabratus