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Literature summary for 4.2.1.1 extracted from

  • Nishimori, I.; Minakuchi, T.; Onishi, S.; Vullo, D.; Cecchi, A.; Scozzafava, A.; Supuran, C.T.
    Carbonic anhydrase inhibitors. Cloning, characterization and inhibition studies of the cytosolic isozyme III with anions (2009), J. Enzyme Inhib. Med. Chem., 24, 70-76.
    View publication on PubMed
Search for more literature for 4.2.1.1

Inhibitors

Inhibitors Comment Organism Structure
azide best inhibitor Homo sapiens
bicarbonate
-
 Homo sapiens
bromide
-
 Homo sapiens
Carbonate best inhibitor Homo sapiens
chloride
-
 Homo sapiens
cyanide best inhibitor Homo sapiens
fluoride weak inhibitor Homo sapiens
hydrogen sulfide best inhibitor Homo sapiens
hydrosulfide
-
 Homo sapiens
nitrate
-
 Homo sapiens
nitrite
-
 Homo sapiens
phenylarsonic acid weak inhibitor Homo sapiens
phenylboronic acid weak inhibitor Homo sapiens
sulfamic acid
-
 Homo sapiens
sulfamide
-
 Homo sapiens
sulfate
-
 Homo sapiens
thiocyanate best inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P07451
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CO2 + H2O
-
 Homo sapiens H2CO3
-
 r

Synonyms

Synonyms Comment Organism
CA I isozyme Homo sapiens
CA II isozyme Homo sapiens
CA III isozyme Homo sapiens
carbonic anhydrase isozyme III
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
13000
-
 CO2 at 20°C and pH 7.5 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.01
-
 Carbonate isozyme CA III Homo sapiens
0.74
-
 bicarbonate isozyme CA III Homo sapiens
12
-
 bicarbonate isozyme CA II Homo sapiens
85
-
 bicarbonate isozyme CA I Homo sapiens