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Literature summary for 4.2.1.1 extracted from

  • Isik, S.; Kockar, F.; Arslan, O.; Guler, O.O.; Innocenti, A.; Supuran, C.T.
    Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with anions (2008), Bioorg. Med. Chem. Lett., 18, 6327-6331.
    View publication on PubMed
Search for more literature for 4.2.1.1

Inhibitors

Inhibitors Comment Organism Structure
acetazolamide i.e. 5-acetamido-1,3,4-thiadiazole-2-sulfonamide Saccharomyces cerevisiae
azide weak inhibition Saccharomyces cerevisiae
bicarbonate
-
 Saccharomyces cerevisiae
bisulfite
-
 Saccharomyces cerevisiae
bromide strong inhibition Saccharomyces cerevisiae
Carbonate
-
 Saccharomyces cerevisiae
chloride
-
 Saccharomyces cerevisiae
Cyanate weak inhibition Saccharomyces cerevisiae
cyanide weak inhibition Saccharomyces cerevisiae
fluoride
-
 Saccharomyces cerevisiae
hydrogen sulfide
-
 Saccharomyces cerevisiae
Iodide strong inhibition Saccharomyces cerevisiae
additional information not inhibited by perchlorate Saccharomyces cerevisiae
nitrate
-
 Saccharomyces cerevisiae
nitrite
-
 Saccharomyces cerevisiae
phenylarsonic acid
-
 Saccharomyces cerevisiae
phenylboronic acid weak inhibition Saccharomyces cerevisiae
sulfamate
-
 Saccharomyces cerevisiae
sulfamide strong inhibition Saccharomyces cerevisiae
sulfate
-
 Saccharomyces cerevisiae
thiocyanate weak inhibition Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CO2 + H2O
-
 Saccharomyces cerevisiae H2CO3
-
 r

Synonyms

Synonyms Comment Organism
beta-carbonic anhydrase
-
 Saccharomyces cerevisiae

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
940000
-
 CO2 at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000082
-
 acetazolamide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
0.0087
-
 sulfamide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
0.0103
-
 Iodide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
0.0108
-
 bromide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
0.33
-
 hydrogen sulfide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
0.33
-
 bisulfite at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
0.33
-
 sulfamate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
0.4
-
 phenylarsonic acid at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
0.46
-
 nitrate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
0.58
-
 sulfate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
0.76
-
 Carbonate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
0.78
-
 bicarbonate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
0.85
-
 chloride at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
2.85
-
 fluoride at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
16.8
-
 cyanide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
27.9
-
 azide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
31.7
-
 Cyanate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
38.2
-
 phenylboronic acid at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
55.6
-
 thiocyanate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae