Literature summary for 4.2.1.1 extracted from

Fisher, S.Z.; Tariku, I.; Case, N.M.; Tu, C.; Seron, T.; Silverman, D.N.; Linser, P.J.; McKenna, R.
Expression, purification, kinetic, and structural characterization of an alpha-class carbonic anhydrase from Aedes aegypti (AaCA1) (2006), Biochim. Biophys. Acta, 764, 1413-1419.

Search for more literature for 4.2.1.1

Application

Application	Comment	Organism
medicine	there are amino acid differences in the active site of AaCA1 of Aedes aegypti and human carbonic anhydrases. Terefore this enzyme could be a potential drug target of selective carbonic anhydrase inhibitors for the control of mosquito populations and the pathogens they carry	Aedes aegypti

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli BL21	Aedes aegypti

Inhibitors

Inhibitors	Comment	Organism	Structure
ethoxzolamide	-	Aedes aegypti
methazolamide	-	Aedes aegypti

Organism

Organism	UniProt	Comment	Textmining
Aedes aegypti	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Aedes aegypti

Source Tissue

Source Tissue	Comment	Organism	Textmining
larva	midgut	Aedes aegypti	-
midgut	of larva	Aedes aegypti	-

Synonyms

Synonyms	Comment	Organism
AaCA1	-	Aedes aegypti
alpha-CA	-	Aedes aegypti

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0000019	-	ethoxzolamide	-	Aedes aegypti
0.0000027	-	methazolamide	-	Aedes aegypti

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)