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Literature summary for 4.2.1.1 extracted from

  • Innocenti, A.; Casini, A.; Alcaro, M.C.; Papini, A.M.; Scozzafava, A.; Supuran, C.T.
    Carbonic anhydrase inhibitors: the first on-resin screening of a 4-sulfamoylphenylthiourea library (2004), J. Med. Chem., 47, 5224-5229.
    View publication on PubMed
Search for more literature for 4.2.1.1

Inhibitors

Inhibitors Comment Organism Structure
2-N-(4-sulfamoylphenyl)-thioformyl-L-Ala
-
 Homo sapiens
2-N-(4-sulfamoylphenyl)-thioformyl-L-Asn
-
 Homo sapiens
2-N-(4-sulfamoylphenyl)-thioformyl-L-Gln
-
 Homo sapiens
2-N-(4-sulfamoylphenyl)-thioformyl-L-Ile
-
 Homo sapiens
2-N-(4-sulfamoylphenyl)-thioformyl-L-Leu
-
 Homo sapiens
2-N-(4-sulfamoylphenyl)-thioformyl-L-Met
-
 Homo sapiens
2-N-(4-sulfamoylphenyl)-thioformyl-L-Phe
-
 Homo sapiens
2-N-(4-sulfamoylphenyl)-thioformyl-L-Pro
-
 Homo sapiens
2-N-(4-sulfamoylphenyl)-thioformyl-L-Trp
-
 Homo sapiens
2-N-(4-sulfamoylphenyl)-thioformyl-L-Val
-
 Homo sapiens
acetazolamide
-
 Homo sapiens
dichlorophenamide
-
 Homo sapiens
dorzolamide
-
 Homo sapiens
ethoxzolamide
-
 Homo sapiens
methazolamide
-
 Homo sapiens
N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-alanine
-
 Homo sapiens
N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-asparagine
-
 Homo sapiens
N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-glutamine
-
 Homo sapiens
N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-isoleucine
-
 Homo sapiens
N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-leucine
-
 Homo sapiens
N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-methionine
-
 Homo sapiens
N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-phenylalanine
-
 Homo sapiens
N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-proline
-
 Homo sapiens
N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-tryptophan
-
 Homo sapiens
N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-valine
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 recombinant
-

Synonyms

Synonyms Comment Organism
carbonic anhydrase I
-
 Homo sapiens
carbonic anhydrase II
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000004
-
 N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-asparagine NovaSyn TGA-resin bound, pH 7.5, carbonic anhydrase II Homo sapiens
0.000004
-
 2-N-(4-sulfamoylphenyl)-thioformyl-L-Ile pH 7.5, carbonic anhydrase II Homo sapiens
0.000004
-
 2-N-(4-sulfamoylphenyl)-thioformyl-L-Met pH 7.5, carbonic anhydrase II Homo sapiens
0.000005
-
 N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-isoleucine NovaSyn TGA-resin bound, pH 7.5, carbonic anhydrase II Homo sapiens
0.000005
-
 N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-methionine NovaSyn TGA-resin bound, pH 7.5, carbonic anhydrase II Homo sapiens
0.000005
-
 N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-valine NovaSyn TGA-resin bound, pH 7.5, carbonic anhydrase II Homo sapiens
0.000005
-
 2-N-(4-sulfamoylphenyl)-thioformyl-L-Leu pH 7.5, carbonic anhydrase II Homo sapiens
0.000005
-
 2-N-(4-sulfamoylphenyl)-thioformyl-L-Val pH 7.5, carbonic anhydrase II Homo sapiens
0.000006
-
 2-N-(4-sulfamoylphenyl)-thioformyl-L-Asn pH 7.5, carbonic anhydrase II Homo sapiens
0.000006
-
 2-N-(4-sulfamoylphenyl)-thioformyl-L-Phe pH 7.5, carbonic anhydrase II Homo sapiens
0.000007
-
 N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-leucine NovaSyn TGA-resin bound, pH 7.5, carbonic anhydrase II Homo sapiens
0.000008
-
 N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-phenylalanine NovaSyn TGA-resin bound, pH 7.5, carbonic anhydrase II Homo sapiens
0.000008
-
 ethoxzolamide pH 7.5, carbonic anhydrase II Homo sapiens
0.000009
-
 dorzolamide pH 7.5, carbonic anhydrase II Homo sapiens
0.000009
-
 2-N-(4-sulfamoylphenyl)-thioformyl-L-Gln pH 7.5, carbonic anhydrase II Homo sapiens
0.000011
-
 N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-glutamine NovaSyn TGA-resin bound, pH 7.5, carbonic anhydrase II Homo sapiens
0.000011
-
 2-N-(4-sulfamoylphenyl)-thioformyl-L-Trp pH 7.5, carbonic anhydrase II Homo sapiens
0.000012
-
 acetazolamide pH 7.5, carbonic anhydrase II Homo sapiens
0.000012
-
 2-N-(4-sulfamoylphenyl)-thioformyl-L-Ala pH 7.5, carbonic anhydrase II Homo sapiens
0.000014
-
 methazolamide pH 7.5, carbonic anhydrase II Homo sapiens
0.000016
-
 N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-alanine NovaSyn TGA-resin bound, pH 7.5, carbonic anhydrase II Homo sapiens
0.00002
-
 N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-tryptophan NovaSyn TGA-resin bound, pH 7.5, carbonic anhydrase II Homo sapiens
0.000021
-
 2-N-(4-sulfamoylphenyl)-thioformyl-L-Leu pH 7.5, carbonic anhydrase I Homo sapiens
0.000022
-
 2-N-(4-sulfamoylphenyl)-thioformyl-L-Ile pH 7.5, carbonic anhydrase I Homo sapiens
0.000023
-
 N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-leucine NovaSyn TGA-resin bound, pH 7.5, carbonic anhydrase I Homo sapiens
0.000023
-
 2-N-(4-sulfamoylphenyl)-thioformyl-L-Val pH 7.5, carbonic anhydrase I Homo sapiens
0.000025
-
 N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-isoleucine NovaSyn TGA-resin bound, pH 7.5, carbonic anhydrase I Homo sapiens
0.000025
-
 ethoxzolamide pH 7.5, carbonic anhydrase I Homo sapiens
0.000025
-
 2-N-(4-sulfamoylphenyl)-thioformyl-L-Pro pH 7.5, carbonic anhydrase II Homo sapiens
0.000027
-
 2-N-(4-sulfamoylphenyl)-thioformyl-L-Asn pH 7.5, carbonic anhydrase I Homo sapiens
0.000027
-
 2-N-(4-sulfamoylphenyl)-thioformyl-L-Met pH 7.5, carbonic anhydrase I Homo sapiens
0.000029
-
 N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-asparagine NovaSyn TGA-resin bound, pH 7.5, carbonic anhydrase I Homo sapiens
0.00003
-
 2-N-(4-sulfamoylphenyl)-thioformyl-L-Phe pH 7.5, carbonic anhydrase I Homo sapiens
0.000031
-
 N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-methionine NovaSyn TGA-resin bound, pH 7.5, carbonic anhydrase I Homo sapiens
0.000031
-
 N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-valine NovaSyn TGA-resin bound, pH 7.5, carbonic anhydrase I Homo sapiens
0.000038
-
 dichlorophenamide pH 7.5, carbonic anhydrase II Homo sapiens
0.00004
-
 2-N-(4-sulfamoylphenyl)-thioformyl-L-Gln pH 7.5, carbonic anhydrase I Homo sapiens
0.000042
-
 N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-phenylalanine NovaSyn TGA-resin bound, pH 7.5, carbonic anhydrase I Homo sapiens
0.000047
-
 2-N-(4-sulfamoylphenyl)-thioformyl-L-Trp pH 7.5, carbonic anhydrase I Homo sapiens
0.000048
-
 N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-proline NovaSyn TGA-resin bound, pH 7.5, carbonic anhydrase II Homo sapiens
0.000053
-
 N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-glutamine NovaSyn TGA-resin bound, pH 7.5, carbonic anhydrase I Homo sapiens
0.000058
-
 N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-alanine NovaSyn TGA-resin bound, pH 7.5, carbonic anhydrase I Homo sapiens
0.000064
-
 N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-tryptophan NovaSyn TGA-resin bound, pH 7.5, carbonic anhydrase I Homo sapiens
0.00011
-
 2-N-(4-sulfamoylphenyl)-thioformyl-L-Pro pH 7.5, carbonic anhydrase I Homo sapiens
0.000197
-
 N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-proline NovaSyn TGA-resin bound, pH 7.5, carbonic anhydrase I Homo sapiens
0.00078
-
 methazolamide pH 7.5, carbonic anhydrase I Homo sapiens
0.0009
-
 acetazolamide pH 7.5, carbonic anhydrase I Homo sapiens
0.0012
-
 2-N-(4-sulfamoylphenyl)-thioformyl-L-Ala pH 7.5, carbonic anhydrase I Homo sapiens
0.05
-
 dorzolamide pH 7.5, carbonic anhydrase I Homo sapiens