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Literature summary for 4.2.1.1 extracted from
- Carbonic anhydrase metabolism is a key factor in the toxicity of CO2 and COS but not CS2 toward the flour beetle Tribolium castaneum [Coleoptera: Tenebrionidae] (2005), Comp. Biochem. Physiol. C, 140, 139-147.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| acetazolamide | - |
Bos taurus |  |
| COS | 3 mM, slightly inhibitory | Bos taurus | |
| ethoxyzolamide | - |
Bos taurus | |
| methazolamide | - |
Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.86 | - |
COS | pH 8-9, 25°C | Bos taurus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Tribolium castaneum | in mortality bioassays, carbonic anhydrase protects Tribolium castaneum from the toxicity of COS but has the opposite effect on COS toxicity. With CS2, carbonic anhydrase has a very minor role, neither facilitating, nor protecting against toxicity | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Tribolium castaneum | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| larva | - |
Tribolium castaneum | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitrophenyl acetate + H2O | - |
Bos taurus | 4-nitrophenol + acetate | - |
? | |
| 4-nitrophenyl acetate + H2O | - |
Tribolium castaneum | 4-nitrophenol + acetate | - |
? | |
| COS + H2O | - |
Bos taurus | CO2 + H2S | - |
? | |
| COS + H2O | - |
Tribolium castaneum | CO2 + H2S | - |
? | |
| CS2 + 2 H2O | - |
Bos taurus | CO2 + 2 H2S | - |
? | |
| CS2 + 2 H2O | - |
Tribolium castaneum | CO2 + 2 H2S | - |
? | |
| additional information | in mortality bioassays, carbonic anhydrase protects Tribolium castaneum from the toxicity of COS but has the opposite effect on COS toxicity. With CS2, carbonic anhydrase has a very minor role, neither facilitating, nor protecting against toxicity | Tribolium castaneum | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| carbonic anhydrase II | - |
Bos taurus |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0005 | - |
CS2 | - |
Bos taurus | |
| 41 | - |
COS | pH 8-9, 25°C | Bos taurus | |
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