Literature summary for 4.2.1.1 extracted from

Whittington, D.A.; Waheed, A.; Ulmasov, B.; Shah, G.N.; Grubb, J.H.; Sly, W.S.; Christianson, D.W.
Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells (2001), Proc. Natl. Acad. Sci. USA, 98, 9545-9550.

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Cloned(Commentary)

Cloned (Comment)	Organism
CA XII expressed in Escherichia coli AD494(DE3)	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
CA XII crystallized by the hanging drop vapor diffusion method, space group C2 with unit cell dimensions a : 146.7 A, b : 44.6 A, c : 85.2 A	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
acetazolamide	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	cytosolic isozyme CA II	Homo sapiens	5829	-
membrane	membrane protein overexpressed in certain cancer tumor cells	Homo sapiens	16020	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	zinc enzyme	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
30000	-	2 * 30000, CA XII, SDS-PAGE	Homo sapiens
30000	31000	CA XII, amino acid sequence, SDS-PAGE	Homo sapiens
60000	-	CA XII, gel filtration	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
H2CO3	Homo sapiens	-	CO2 + H2O	-	r

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O43570	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
H2CO3	-	Homo sapiens	CO2 + H2O	-	r

Subunits

Subunits	Comment	Organism
dimer	2 * 30000, CA XII, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
CA	-	Homo sapiens
hCA XII	-	Homo sapiens
human carbonic anhydrase XII	-	Homo sapiens
isozyme CA II	-	Homo sapiens
isozyme CA IV	-	Homo sapiens

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Release 2023.1 (January 2023)