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Literature summary for 4.2.1.1 extracted from

  • Ul-Hassan, M.; Scozzafava, A.; Chohan, Z.H.; Supuran, C.T.
    Carbonic anhydrase inhibitors: Metal complexes of a sulfanilamide derived schiff base and their interaction with isozymes I, II and IV (2001), J. Enzyme Inhib., 16, 499-505.
    View publication on PubMed
Search for more literature for 4.2.1.1

Cloned(Commentary)

Cloned (Comment) Organism
CA I and CA II cDNAs expressed in Escherichia coli BL21 (DE3) Homo sapiens
CA I and CA II cDNAs expressed in Escherichia coli BL21 (DE3) Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
4-Aminobenzenesulfonamide
-
 Bos taurus
4-Aminobenzenesulfonamide
-
 Homo sapiens
N-salicylidene-sulfanilic acid amide
-
 Bos taurus
N-salicylidene-sulfanilic acid amide
-
 Homo sapiens
N-salicylidene-sulfanilic acid amide cobalt acetate complex
-
 Bos taurus
N-salicylidene-sulfanilic acid amide cobalt acetate complex
-
 Homo sapiens
N-salicylidene-sulfanilic acid amide cobalt chloride complex
-
 Bos taurus
N-salicylidene-sulfanilic acid amide cobalt chloride complex
-
 Homo sapiens
N-salicylidene-sulfanilic acid amide cobalt nitrate complex
-
 Bos taurus
N-salicylidene-sulfanilic acid amide cobalt nitrate complex
-
 Homo sapiens
N-salicylidene-sulfanilic acid amide cobalt sulfate complex
-
 Bos taurus
N-salicylidene-sulfanilic acid amide cobalt sulfate complex
-
 Homo sapiens
N-salicylidene-sulfanilic acid amide copper chloride complex
-
 Bos taurus
N-salicylidene-sulfanilic acid amide copper chloride complex
-
 Homo sapiens
N-salicylidene-sulfanilic acid amide copper nitrate complex
-
 Bos taurus
N-salicylidene-sulfanilic acid amide copper nitrate complex
-
 Homo sapiens
N-salicylidene-sulfanilic acid amide nickel acetate complex
-
 Bos taurus
N-salicylidene-sulfanilic acid amide nickel acetate complex
-
 Homo sapiens
N-salicylidene-sulfanilic acid amide nickel chloride complex
-
 Bos taurus
N-salicylidene-sulfanilic acid amide nickel chloride complex
-
 Homo sapiens
N-salicylidene-sulfanilic acid amide nickel nitrate complex
-
 Bos taurus
N-salicylidene-sulfanilic acid amide nickel nitrate complex
-
 Homo sapiens
N-salicylidene-sulfanilic acid amide nickel sulfate complex
-
 Bos taurus
N-salicylidene-sulfanilic acid amide nickel sulfate complex
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Bos taurus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc enzyme Homo sapiens
Zn2+ zinc enzyme Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
H2CO3 Homo sapiens
-
 CO2 + H2O
-
 r
H2CO3 Bos taurus
-
 CO2 + H2O
-
 r

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl acetate + H2O
-
 Homo sapiens 4-nitrophenol + acetate
-
 r
4-nitrophenyl acetate + H2O
-
 Bos taurus 4-nitrophenol + acetate
-
 r
H2CO3
-
 Homo sapiens CO2 + H2O
-
 r
H2CO3
-
 Bos taurus CO2 + H2O
-
 r

Synonyms

Synonyms Comment Organism
bCA IV
-
 Bos taurus
carbonic anhydrase
-
 Homo sapiens
carbonic anhydrase
-
 Bos taurus
carbonic anhydrase isozyme I
-
 Homo sapiens
carbonic anhydrase isozyme II
-
 Homo sapiens
carbonic anhydrase isozyme IV
-
 Homo sapiens
carbonic anhydrase isozyme IV
-
 Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000013
-
 N-salicylidene-sulfanilic acid amide copper chloride complex pH 7.4, 25°C, isozyme hCA II Homo sapiens
0.000015
-
 N-salicylidene-sulfanilic acid amide copper nitrate complex pH 7.4, 25°C, isozyme hCA II Homo sapiens
0.000022
-
 N-salicylidene-sulfanilic acid amide cobalt sulfate complex pH 7.4, 25°C, isozyme hCA II Homo sapiens
0.000023
-
 N-salicylidene-sulfanilic acid amide cobalt acetate complex pH 7.4, 25°C, isozyme hCA II Homo sapiens
0.000024
-
 N-salicylidene-sulfanilic acid amide cobalt chloride complex pH 7.4, 25°C, isozyme hCA II Homo sapiens
0.000025
-
 N-salicylidene-sulfanilic acid amide cobalt nitrate complex pH 7.4, 25°C, isozyme hCA II Homo sapiens
0.000036
-
 N-salicylidene-sulfanilic acid amide nickel sulfate complex pH 7.4, 25°C, isozyme hCA II Homo sapiens
0.000037
-
 N-salicylidene-sulfanilic acid amide nickel acetate complex pH 7.4, 25°C, isozyme hCA II Homo sapiens
0.000039
-
 N-salicylidene-sulfanilic acid amide nickel nitrate complex pH 7.4, 25°C, isozyme hCA II Homo sapiens
0.000039
-
 N-salicylidene-sulfanilic acid amide nickel chloride complex pH 7.4, 25°C, isozyme hCA II Homo sapiens
0.000072
-
 N-salicylidene-sulfanilic acid amide cobalt sulfate complex pH 7.4, 25°C, isozyme bCA IV Bos taurus
0.000073
-
 N-salicylidene-sulfanilic acid amide cobalt nitrate complex pH 7.4, 25°C, isozyme bCA IV Bos taurus
0.000073
-
 N-salicylidene-sulfanilic acid amide cobalt acetate complex pH 7.4, 25°C, isozyme bCA IV Bos taurus
0.000078
-
 N-salicylidene-sulfanilic acid amide cobalt chloride complex pH 7.4, 25°C, isozyme bCA IV Bos taurus
0.00008
-
 N-salicylidene-sulfanilic acid amide copper nitrate complex pH 7.4, 25°C, isozyme bCA IV Bos taurus
0.000083
-
 N-salicylidene-sulfanilic acid amide copper chloride complex pH 7.4, 25°C, isozyme bCA IV Bos taurus
0.000102
-
 N-salicylidene-sulfanilic acid amide nickel nitrate complex pH 7.4, 25°C, isozyme bCA IV Bos taurus
0.000105
-
 N-salicylidene-sulfanilic acid amide nickel chloride complex pH 7.4, 25°C, isozyme bCA IV Bos taurus
0.000106
-
 N-salicylidene-sulfanilic acid amide nickel sulfate complex pH 7.4, 25°C, isozyme bCA IV Bos taurus
0.000108
-
 N-salicylidene-sulfanilic acid amide nickel acetate complex pH 7.4, 25°C, isozyme bCA IV Bos taurus
0.00021
-
 N-salicylidene-sulfanilic acid amide copper chloride complex pH 7.4, 25°C, isozyme hCA I Homo sapiens
0.00024
-
 N-salicylidene-sulfanilic acid amide copper nitrate complex pH 7.4, 25°C, isozyme hCA I Homo sapiens
0.0003
-
 4-Aminobenzenesulfonamide pH 7.4, 25°C, isozyme hCA II Homo sapiens
0.00032
-
 N-salicylidene-sulfanilic acid amide cobalt nitrate complex pH 7.4, 25°C, isozyme hCA I Homo sapiens
0.00033
-
 N-salicylidene-sulfanilic acid amide cobalt chloride complex pH 7.4, 25°C, isozyme hCA I Homo sapiens
0.00033
-
 N-salicylidene-sulfanilic acid amide cobalt acetate complex pH 7.4, 25°C, isozyme hCA I Homo sapiens
0.00035
-
 N-salicylidene-sulfanilic acid amide cobalt sulfate complex pH 7.4, 25°C, isozyme hCA I Homo sapiens
0.00041
-
 N-salicylidene-sulfanilic acid amide pH 7.4, 25°C, isozyme hCA II Homo sapiens
0.00042
-
 N-salicylidene-sulfanilic acid amide pH 7.4, 25°C, isozyme bCA IV Bos taurus
0.00054
-
 N-salicylidene-sulfanilic acid amide nickel chloride complex pH 7.4, 25°C, isozyme hCA I Homo sapiens
0.00055
-
 N-salicylidene-sulfanilic acid amide nickel acetate complex pH 7.4, 25°C, isozyme hCA I Homo sapiens
0.00055
-
 N-salicylidene-sulfanilic acid amide nickel sulfate complex pH 7.4, 25°C, isozyme hCA I Homo sapiens
0.00056
-
 N-salicylidene-sulfanilic acid amide nickel nitrate complex pH 7.4, 25°C, isozyme hCA I Homo sapiens
0.003
-
 4-Aminobenzenesulfonamide pH 7.4, 25°C, isozyme bCA IV Bos taurus
0.02
-
 4-Aminobenzenesulfonamide pH 7.4, 25°C, isozyme hCA I Homo sapiens
0.03
-
 N-salicylidene-sulfanilic acid amide pH 7.4, 25°C, isozyme hCA I Homo sapiens