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Literature summary for 4.2.1.1 extracted from

  • Wingo, T.; Tu, C.; Laipis, P.J.; Silverman, D.N.
    The catalytic properties of human carbonic anhydrase IX (2001), Biochem. Biophys. Res. Commun., 288, 666-669.
    View publication on PubMed
Search for more literature for 4.2.1.1

Cloned(Commentary)

Cloned (Comment) Organism
cDNA expressed in Escherichia coli BL21(DE3)pLysS Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
acetazolamide
-
 Homo sapiens
Cyanate
-
 Homo sapiens
ethoxzolamide
-
 Homo sapiens
methazolamide
-
 Homo sapiens
sulfonamide
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane integral membrane protein Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
H2CO3 Homo sapiens
-
 CO2 + H2O
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H2CO3
-
 Homo sapiens CO2 + H2O
-
 r

Synonyms

Synonyms Comment Organism
alpha-class carbonic anhydrase
-
 Homo sapiens
CA II
-
 Homo sapiens
CA IX
-
 Homo sapiens
human carbonic anhydrase IX
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
-
 Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
5 9
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000003
-
 acetazolamide pH 7.6, 4°C Homo sapiens
0.000009
-
 methazolamide pH 7.6, 4°C Homo sapiens
0.046
-
 Cyanate pH 7.6, 4°C Homo sapiens