Cloned (Comment) | Organism |
---|---|
genes phr1 and phr2, transient expression of C-terminally EGFP-tagged PHR1 and 2 in HEK 293T cells using vector pcDNA3.1, cotransfection with empty vector, Flag-Clock, or Flag-Bmal1 | Chrysodeixis chalcites nucleopolyhedrovirus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Chrysodeixis chalcites nucleopolyhedrovirus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Chrysodeixis chalcites nucleopolyhedrovirus | PHR1 and PHR2 are able to bind the CLOCK protein, a transcription activator controlling the molecular circadian clock. But only for PHR2, the physical interaction with CLOCK represses CLOCK/BMAL1-driven transcription, binding of photolyase per se is not sufficient to inhibit the CLOCK/BMAL1 heterodimer | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Chrysodeixis chalcites nucleopolyhedrovirus | - |
2 photolyase-like genes phr1 and phr2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | PHR1 and PHR2 colocalize with the CLOCK protein | Chrysodeixis chalcites nucleopolyhedrovirus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PHR1 and PHR2 are able to bind the CLOCK protein, a transcription activator controlling the molecular circadian clock. But only for PHR2, the physical interaction with CLOCK represses CLOCK/BMAL1-driven transcription, binding of photolyase per se is not sufficient to inhibit the CLOCK/BMAL1 heterodimer | Chrysodeixis chalcites nucleopolyhedrovirus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
photolyase | - |
Chrysodeixis chalcites nucleopolyhedrovirus |
PHR1 | - |
Chrysodeixis chalcites nucleopolyhedrovirus |
PHR2 | - |
Chrysodeixis chalcites nucleopolyhedrovirus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
5,10-methenyltetrahydrofolate | - |
Chrysodeixis chalcites nucleopolyhedrovirus | |
FAD | - |
Chrysodeixis chalcites nucleopolyhedrovirus |
General Information | Comment | Organism |
---|---|---|
physiological function | photolyases use visible light to repair ultraviolet-induced DNA damage. PHR2 binds the CLOCK protein and represses CLOCK/BMAL1-driven transcription, it also affects the oscillation of immortalized mouse embryonic fibroblasts, suggesting that PHR2 can regulate the molecular circadian clock | Chrysodeixis chalcites nucleopolyhedrovirus |