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Literature summary for 4.1.99.3 extracted from

  • Biernat, M.A.; Eker, A.P.; van Oers, M.M.; Vlak, J.M.; van der Horst, G.T.; Chaves, I.
    A baculovirus photolyase with DNA repair activity and circadian clock regulatory function (2012), J. Biol. Rhythms, 27, 3-11.
    View publication on PubMed
Search for more literature for 4.1.99.3

Cloned(Commentary)

Cloned (Comment) Organism
genes phr1 and phr2, transient expression of C-terminally EGFP-tagged PHR1 and 2 in HEK 293T cells using vector pcDNA3.1, cotransfection with empty vector, Flag-Clock, or Flag-Bmal1 Chrysodeixis chalcites nucleopolyhedrovirus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
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 Chrysodeixis chalcites nucleopolyhedrovirus 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Chrysodeixis chalcites nucleopolyhedrovirus PHR1 and PHR2 are able to bind the CLOCK protein, a transcription activator controlling the molecular circadian clock. But only for PHR2, the physical interaction with CLOCK represses CLOCK/BMAL1-driven transcription, binding of photolyase per se is not sufficient to inhibit the CLOCK/BMAL1 heterodimer ?
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 ?

Organism

Organism UniProt Comment Textmining
Chrysodeixis chalcites nucleopolyhedrovirus
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 2 photolyase-like genes phr1 and phr2
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Source Tissue

Source Tissue Comment Organism Textmining
additional information PHR1 and PHR2 colocalize with the CLOCK protein Chrysodeixis chalcites nucleopolyhedrovirus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PHR1 and PHR2 are able to bind the CLOCK protein, a transcription activator controlling the molecular circadian clock. But only for PHR2, the physical interaction with CLOCK represses CLOCK/BMAL1-driven transcription, binding of photolyase per se is not sufficient to inhibit the CLOCK/BMAL1 heterodimer Chrysodeixis chalcites nucleopolyhedrovirus ?
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 ?

Synonyms

Synonyms Comment Organism
photolyase
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 Chrysodeixis chalcites nucleopolyhedrovirus
PHR1
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 Chrysodeixis chalcites nucleopolyhedrovirus
PHR2
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 Chrysodeixis chalcites nucleopolyhedrovirus

Cofactor

Cofactor Comment Organism Structure
5,10-methenyltetrahydrofolate
-
 Chrysodeixis chalcites nucleopolyhedrovirus
FAD
-
 Chrysodeixis chalcites nucleopolyhedrovirus

General Information

General Information Comment Organism
physiological function photolyases use visible light to repair ultraviolet-induced DNA damage. PHR2 binds the CLOCK protein and represses CLOCK/BMAL1-driven transcription, it also affects the oscillation of immortalized mouse embryonic fibroblasts, suggesting that PHR2 can regulate the molecular circadian clock Chrysodeixis chalcites nucleopolyhedrovirus