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Literature summary for 4.1.99.3 extracted from

  • Osburne, M.S.; Holmbeck, B.M.; Frias-Lopez, J.; Steen, R.; Huang, K.; Kelly, L.; Coe, A.; Waraska, K.; Gagne, A.; Chisholm, S.W.
    UV hyper-resistance in Prochlorococcus MED4 results from a single base pair deletion just upstream of an operon encoding nudix hydrolase and photolyase (2010), Environ. Microbiol., 12, 1978-1988.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Prochlorococcus sp.
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Prochlorococcus sp. MED4
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Synonyms

Synonyms Comment Organism
PhrB
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 Prochlorococcus sp.

Expression

Organism Comment Expression
Prochlorococcus sp. For MED4 wild-type, by 60 min post treatment the transcript levels of phrB, mutT and radA drop down
Prochlorococcus sp. is more highly expressed in MED4 UV-hyper-resistant strain relative to MED4 wild-type. In the absence of UV treatment, in steady-state growth, MED4 UV-hyper-resistant strain has considerably higher levels of phrB and mutT transcripts relative to MED4 wild-type. For MED4 wild-type, phrB, mutT and radA are rapidly upregulated, showing elevated transcript levels by 5 min post treatment. For MED4 UV-hyper-resistant strain, phrB, mutT and radA are slightly upregulated following UV irradiation, with transcripts decreasing slightly between 5 and 60 min up

General Information

General Information Comment Organism
physiological function PhrB breaks pyrimidine dimers caused by UV exposure, using energy from visible light in the process of photoreactivation. UV-hyper-resistant strain contains a single mutation: a 1 bp deletion in the intergenic region directly upstream of the mutT-phrB operon, encoding nudix hydrolase and photolyase Prochlorococcus sp.