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Literature summary for 4.1.99.3 extracted from
- The phrA gene of Rhodobacter sphaeroides encodes a photolyase and is regulated by singlet oxygen and peroxide in a sigma(E)-dependent manner (2007), Microbiology, 153, 1842-1851.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| genome of the facultatively photosynthetic bacterium Rhodobacter sphaeroides encodes three proteins of the photolyase/cryptochrome family. It is shown that phrA (RSP2143) encodes a functional photolyase, which is an enzyme that repairs UV radiation-induced DNA damage in a blue light dependent manner | Cereibacter sphaeroides |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| deltaphrA | Rhodobacter sphaeroides mutant cells lacking the PhrA gene show a significant reduced survival rate after UV-illumination | Cereibacter sphaeroides |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cereibacter sphaeroides | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | expression of phrA is upregulated in response to light. Furthermore, it is shown that singlet oxygen and hydrogen peroxide dependent signals are transmitted by the sigmaE factor and the anti-sigmaE factor ChrR affecting phrA expression, while superoxide anions do not stimulate phrA expression | Cereibacter sphaeroides | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
specific activity is shown by an enhanced survival rate of wildtype Rhodobacter sphaeroides (53%) cells compared to deltaphrA cells (3%) after exposure to UV light. A complementation by plasmid-borne phrA restores photoreactivation properties and increases the survival rate of the deletion mutant 14fold | Cereibacter sphaeroides |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phrA | - |
Cereibacter sphaeroides |
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Release 2023.1 (January 2023)
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