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Literature summary for 4.1.99.26 extracted from

  • Haft, D.
    Bioinformatic evidence for a widely distributed, ribosomally produced electron carrier precursor, its maturation proteins, and its nicotinoprotein redox partners (2011), BMC Genomics, 12, 21 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.99.26

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-4-[2-aminoethenyl]phenol + S-adenosyl-L-methionine + AH2 Mycobacterium tuberculosis
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 C-terminal [mycofactocin precursor peptide]-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + 5'-deoxyadenosine + L-methionine + A
-
 ?
C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-4-[2-aminoethenyl]phenol + S-adenosyl-L-methionine + AH2 Mycobacterium tuberculosis H37Rv
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 C-terminal [mycofactocin precursor peptide]-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + 5'-deoxyadenosine + L-methionine + A
-
 ?
C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-4-[2-aminoethenyl]phenol + S-adenosyl-L-methionine + AH2 Mycobacterium tuberculosis ATCC 25618
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 C-terminal [mycofactocin precursor peptide]-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + 5'-deoxyadenosine + L-methionine + A
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WJ79
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Mycobacterium tuberculosis ATCC 25618 P9WJ79
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Mycobacterium tuberculosis H37Rv P9WJ79
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-4-[2-aminoethenyl]phenol + S-adenosyl-L-methionine + AH2
-
 Mycobacterium tuberculosis C-terminal [mycofactocin precursor peptide]-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + 5'-deoxyadenosine + L-methionine + A
-
 ?
C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-4-[2-aminoethenyl]phenol + S-adenosyl-L-methionine + AH2
-
 Mycobacterium tuberculosis H37Rv C-terminal [mycofactocin precursor peptide]-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + 5'-deoxyadenosine + L-methionine + A
-
 ?
C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-4-[2-aminoethenyl]phenol + S-adenosyl-L-methionine + AH2
-
 Mycobacterium tuberculosis ATCC 25618 C-terminal [mycofactocin precursor peptide]-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + 5'-deoxyadenosine + L-methionine + A
-
 ?
additional information Rv0693 likely targets a small peptide for modification Mycobacterium tuberculosis ?
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additional information Rv0693 likely targets a small peptide for modification Mycobacterium tuberculosis H37Rv ?
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additional information Rv0693 likely targets a small peptide for modification Mycobacterium tuberculosis ATCC 25618 ?
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Synonyms

Synonyms Comment Organism
mftC
-
 Mycobacterium tuberculosis
mycofactocin maturase
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 Mycobacterium tuberculosis
Rv0693
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 Mycobacterium tuberculosis
[mycofactocin precursor peptide]-pyrrolidinone derivative synthase UniProt Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Mycobacterium tuberculosis

General Information

General Information Comment Organism
evolution the enzyme belongs to the PqqE-like rSAM protein family, part of the radical SAM domain superfamily. Members occur clustered with a well-conserved small polypeptide mycofactocin, similar in size to bacteriocins and PqqA, precursor of pyrroloquinoline quinone (PQQ). Partial phylogenetic profiling identifies the mycofactocin cluster. The mycofactocin precursor is modified by the gene Rv0693 family rSAM protein and other enzymes in its cluster. Rv0693 belongs to a branch of the radical SAM family in which known or presumed substrates are short peptides. The Rv0693 family radical SAM protein modifies the TIGR03969 family peptide to produce a bioactive molecule: a bacteriocin, a redox cofactor like PQQ, or a signaling metabolite such as Pep1357. The neighboring glycosyltransferase (Rv0696) likely also participates. Based on its near universal distribution in the genus Mycobacterium (among many other Actinobacteria), and analogy of its biosynthesis cluster to PQQ cofactor and bacteriocin biosynthesis clusters, the name mycofactocin is proposed for members of this family. Additional protein families co-cluster with the mycofactocin precursor, mycofactocin cluster-containing genomes and linked oxidoreductases, detailed overview Mycobacterium tuberculosis
additional information multiple sequence alignment of gene predictions for mycofactocin precursors, overview Mycobacterium tuberculosis
physiological function the mycofactocin precursor is modified by the gene Rv0693 family rSAM protein and other enzymes in its cluster. It becomes an electron carrier molecule that serves in vivo as NDMA and other artificial electron acceptors do in vitro Mycobacterium tuberculosis
physiological function the mycofactocin precursor is modified by the Rv0693 family radical SAM protein and other enzymes in its cluster. It becomes an electron carrier molecule that serves in vivo as N,N-dimethyl-4-nitrosoaniline and other artificial electron acceptors do in vitro Mycobacterium tuberculosis