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Literature summary for 4.1.99.22 extracted from

  • Hover, B.M.; Tonthat, N.K.; Schumacher, M.A.; Yokoyama, K.
    Mechanism of pyranopterin ring formation in molybdenum cofactor biosynthesis (2015), Proc. Natl. Acad. Sci. USA, 112, 6347-6352.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Staphylococcus aureus P69848
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Staphylococcus aureus NCTC 8325 P69848
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + S-adenosyl-L-methionine + reduced electron acceptor
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 Staphylococcus aureus (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + oxidized electron acceptor pyranopterin triphosphate is formed as a by-product, the amount is 0.4–3% of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine formed ?
GTP + S-adenosyl-L-methionine + reduced electron acceptor
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 Staphylococcus aureus NCTC 8325 (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + oxidized electron acceptor pyranopterin triphosphate is formed as a by-product, the amount is 0.4–3% of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine formed ?

General Information

General Information Comment Organism
physiological function the physiological function of MoaA is the conversion of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate (GTP 3?,8-cyclase), and that of MoaC is to catalyze the rearrangement of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate into cyclic pyranopterin Staphylococcus aureus