BRENDA - Enzyme Database
show all sequences of 4.1.99.16

A single terpene synthase is responsible for a wide variety of sesquiterpenes in Sorangium cellulosum Soce56

Schifrin, A.; Khatri, Y.; Kirsch, P.; Thiel, V.; Schulz, S.; Bernhardt, R.; Org. Biomol. Chem. 14, 3385-3393 (2016)

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
gene sce1440, recombinant expression in Escherichia coli
Sorangium cellulosum
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O
Sorangium cellulosum
-
(-)-geosmin + acetone
-
-
?
(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O
Sorangium cellulosum Soce56
-
(-)-geosmin + acetone
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Sorangium cellulosum
A9F845
-
-
Sorangium cellulosum Soce56
A9F845
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O
-
743387
Sorangium cellulosum
(-)-geosmin + acetone
-
-
-
?
(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O
-
743387
Sorangium cellulosum Soce56
(-)-geosmin + acetone
-
-
-
?
additional information
the geosmin synthase sce1440 from Sorangium cellulosum strain Soce56 is very substrate-specific
743387
Sorangium cellulosum
?
-
-
-
-
additional information
the geosmin synthase sce1440 from Sorangium cellulosum strain Soce56 is very substrate-specific
743387
Sorangium cellulosum Soce56
?
-
-
-
-
Synonyms
Synonyms
Commentary
Organism
sce1440
-
Sorangium cellulosum
Cloned(Commentary) (protein specific)
Commentary
Organism
gene sce1440, recombinant expression in Escherichia coli
Sorangium cellulosum
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O
Sorangium cellulosum
-
(-)-geosmin + acetone
-
-
?
(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O
Sorangium cellulosum Soce56
-
(-)-geosmin + acetone
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O
-
743387
Sorangium cellulosum
(-)-geosmin + acetone
-
-
-
?
(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O
-
743387
Sorangium cellulosum Soce56
(-)-geosmin + acetone
-
-
-
?
additional information
the geosmin synthase sce1440 from Sorangium cellulosum strain Soce56 is very substrate-specific
743387
Sorangium cellulosum
?
-
-
-
-
additional information
the geosmin synthase sce1440 from Sorangium cellulosum strain Soce56 is very substrate-specific
743387
Sorangium cellulosum Soce56
?
-
-
-
-
General Information
General Information
Commentary
Organism
evolution
identification of Sesquiterpene synthase orthologues of sce1440 in the genomes of myxobacterial strains, overview
Sorangium cellulosum
metabolism
the enzyme is one of only three type I terpene synthases (TSs, sce1440, sce6369, sce8552) and one type II TS (sce4636), responsible for the production of at least 17 sesquiterpenes in Sorangium cellulosum
Sorangium cellulosum
General Information (protein specific)
General Information
Commentary
Organism
evolution
identification of Sesquiterpene synthase orthologues of sce1440 in the genomes of myxobacterial strains, overview
Sorangium cellulosum
metabolism
the enzyme is one of only three type I terpene synthases (TSs, sce1440, sce6369, sce8552) and one type II TS (sce4636), responsible for the production of at least 17 sesquiterpenes in Sorangium cellulosum
Sorangium cellulosum
Other publictions for EC
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
743387
Schifrin
A single terpene synthase is ...
Sorangium cellulosum, Sorangium cellulosum Soce56
Org. Biomol. Chem.
14
3385-3393
2016
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1
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4
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2
2
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747096
Harris
Structural studies of geosmin ...
Streptomyces coelicolor, Streptomyces coelicolor ATCC BAA-471 / A3(2) / M145
Biochemistry
54
7142-7155
2015
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1
1
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1
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3
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1
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6
1
2
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1
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4
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1
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6
1
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2
2
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747590
Zhou
-
Cloning and expression analys ...
Aphanizomenon gracile, Aphanizomenon gracile WH-1
Chin. J. Appl. Environ. Biol.
21
824-829
2015
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1
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2
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2
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1
1
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728186
Giglio
Expression of the geosmin synt ...
Dolichospermum circinale, Dolichospermum circinale AWQC318
J. Phycol.
47
1338-1343
2011
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1
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2
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4
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1
1
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712642
Singh
Exploration of geosmin synthas ...
Streptomyces peucetius, Streptomyces peucetius ATCC 27952
J. Ind. Microbiol. Biotechnol.
36
1257-1265
2009
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6
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1
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692761
Jiang
Geosmin biosynthesis. Mechanis ...
Streptomyces coelicolor
J. Am. Chem. Soc.
130
428-429
2008
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680396
Cane
Geosmin biosynthesis in Strept ...
Streptomyces avermitilis
J. Antibiot.
59
471-479
2006
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1
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1
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7
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1
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1
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7
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1
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