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Literature summary for 4.1.3.4 extracted from

  • Isaac, D.T.; Coady, A.; Van Prooyen, N.; Sil, A.
    The 3-hydroxy-methylglutaryl coenzyme A lyase HCL1 is required for macrophage colonization by human fungal pathogen Histoplasma capsulatum (2013), Infect. Immun., 81, 411-420.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene hcl1 Histoplasma capsulatum

Protein Variants

Protein Variants Comment Organism
additional information screening for enzyme mutants, identification of naturally occuring mutant FE6-C3 with disrupted gene encoding the enzyme Histoplasma capsulatum

Organism

Organism UniProt Comment Textmining
Histoplasma capsulatum
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gene hcl1
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Source Tissue

Source Tissue Comment Organism Textmining
additional information the organism survives and replicates within the phagolysosome of human host macrophages Histoplasma capsulatum
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Synonyms

Synonyms Comment Organism
3-hydroxy-methylglutaryl coenzyme A lyase
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Histoplasma capsulatum
HCL1
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Histoplasma capsulatum
HMG CoA lyase
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Histoplasma capsulatum

General Information

General Information Comment Organism
malfunction an insertion mutant strain FE6-C3 with disrupted 3-hydroxy-methylglutaryl coenzyme A lyase homologue HCL shows inability to lyse macrophages, the hcl1 mutant has a severe growth defect in bone marrow-derived macrophages. The mutant cell deficient in HMG CoA lyase accumulates acidic intermediates as a consequence of its inability to catabolize leucine, phenotype, overview Histoplasma capsulatum
metabolism the enzyme catalyzes the last step in the leucine catabolism pathway Histoplasma capsulatum
physiological function the enzyme is required for macrophage colonization by human fungal pathogen Histoplasma capsulatum Histoplasma capsulatum