Cloned (Comment) | Organism |
---|---|
gene hcl1 | Histoplasma capsulatum |
Protein Variants | Comment | Organism |
---|---|---|
additional information | screening for enzyme mutants, identification of naturally occuring mutant FE6-C3 with disrupted gene encoding the enzyme | Histoplasma capsulatum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Histoplasma capsulatum | - |
gene hcl1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | the organism survives and replicates within the phagolysosome of human host macrophages | Histoplasma capsulatum | - |
Synonyms | Comment | Organism |
---|---|---|
3-hydroxy-methylglutaryl coenzyme A lyase | - |
Histoplasma capsulatum |
HCL1 | - |
Histoplasma capsulatum |
HMG CoA lyase | - |
Histoplasma capsulatum |
General Information | Comment | Organism |
---|---|---|
malfunction | an insertion mutant strain FE6-C3 with disrupted 3-hydroxy-methylglutaryl coenzyme A lyase homologue HCL shows inability to lyse macrophages, the hcl1 mutant has a severe growth defect in bone marrow-derived macrophages. The mutant cell deficient in HMG CoA lyase accumulates acidic intermediates as a consequence of its inability to catabolize leucine, phenotype, overview | Histoplasma capsulatum |
metabolism | the enzyme catalyzes the last step in the leucine catabolism pathway | Histoplasma capsulatum |
physiological function | the enzyme is required for macrophage colonization by human fungal pathogen Histoplasma capsulatum | Histoplasma capsulatum |