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Literature summary for 4.1.3.4 extracted from
- Avian 3-hydroxy-3-methylglutaryl-CoA lyase: sensitivity of enzyme activity to thiol/disulfide exchange and identification of proximal reactive cysteines (1992), Protein Sci., 1, 1144-1153.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-butynoyl-CoA | sensitivity to inactivation depends on redox state of enzyme, Kinact: 0.22 min-1, reduced, 0.03 min 1, oxidized | Gallus gallus |  |
| 4-Methylnitrobenzene sulfonate | sensitivity to inactivation depends on redox state of enzyme, Kinact: 0.178 min-1, reduced, 0.028 min 1, oxidized | Gallus gallus | |
| additional information | 99% inactivation after air-oxidation, various sulfhydryl-directed agents | Gallus gallus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
chicken | - |
| Tetrahymena pyriformis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Gallus gallus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| (S)-3-Hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate | identification of reactive cysteines, possibly regulatory mechanism via thiol/disulfide exchange | Gallus gallus |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | amino acid composition | Gallus gallus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
- |
Gallus gallus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.2 | - |
enzyme assay at | Gallus gallus |
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Release 2023.1 (January 2023)
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