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Literature summary for 4.1.3.4 extracted from

  • Kramer, P.R.; Miziorko, H.M.
    3-Hydroxy-3-methylglutaryl-CoA lyase: catalysis of acetyl coenzyme A enolization (1983), Biochemistry, 22, 2353-2357.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3-hydroxyglutaryl-CoA Ki: 0.05 mM, Ki of acetyl-CoA enolization: 0.095 mM Anas sp.
S-(4-carboxy-3hydroxyisoamyl)-CoA Ki: 0.08 mM Anas sp.

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ possibly involved in coordination of the thioesther carbonyl during catalysis, also stimulates acetyl-CoA enolization Anas sp.

Organism

Organism UniProt Comment Textmining
Anas sp.
-
duck
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Anas sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-3-Hydroxy-3-methylglutaryl-CoA mechanism Anas sp. Acetyl-CoA + acetoacetate
-
?
Acetyl-CoA enolization Anas sp. ?
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.05
-
3-hydroxyglutaryl-CoA
-
Anas sp.
0.08
-
S-(4-carboxy-3hydroxyisoamyl)-CoA
-
Anas sp.