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Literature summary for 4.1.3.3 extracted from

  • Barbosa, J.A.R.G.; Smith, B.J.; DeGori, R.; Ooi, H.C.; Marcuccio, S.M.; Campi, E.M.; Jackson, W.R.; Brossmer, R.; Sommer, M.; Lawrence, M.C.
    Active Site Modulation in the N-Acetylneuraminate Lyase Sub-family as Revealed by the Structure of the Inhibitor-complexed Haemophilus influenzae Enzyme (2000), J. Mol. Biol., 303, 405-421.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
complexed with sialic acid alditol, 4-deoxy-sialic acid or 4-oxo-sialic acid, microbatch crystallization, hanging drop vapor diffusion method Haemophilus influenzae

Inhibitors

Inhibitors Comment Organism Structure
Ag+ 36% inhibition after 15 min at 20°C Homo sapiens
Hg2+ 43% inhibition after 15 min at 20°C Homo sapiens
pyruvate 36% inhibition at 1 mM, 65% inhibition at 5 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4
-
N-acetylneuraminic acid pH 7.4, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-Acetylneuraminic acid Homo sapiens regulation of sialic acid metabolism N-Acetyl-D-mannosamine + pyruvate
-
r

Organism

Organism UniProt Comment Textmining
Haemophilus influenzae
-
-
-
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
aceneuramate = N-acetyl-D-mannosamine + pyruvate mechanism Haemophilus influenzae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-Acetylneuraminic acid
-
Haemophilus influenzae N-Acetyl-D-mannosamine + pyruvate
-
r
N-Acetylneuraminic acid
-
Homo sapiens N-Acetyl-D-mannosamine + pyruvate
-
r
N-Acetylneuraminic acid regulation of sialic acid metabolism Homo sapiens N-Acetyl-D-mannosamine + pyruvate
-
r
N-Glycolylneuraminic acid 60% the rate of N-acetylneuraminic acid Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
NAL
-
Haemophilus influenzae
sialate aldolase
-
Homo sapiens
sialate-pyruvate lyase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
70
-
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.2
-
pyruvate pH 7.4, 37°C Homo sapiens