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Literature summary for 4.1.3.27 extracted from

  • Svarcova, M.; Kratky, M.; Vinsova, J.
    Investigation of potential inhibitors of chorismate-utilizing enzymes (2015), Curr. Med. Chem., 22, 1383-1399 .
    View publication on PubMed
Search for more literature for 4.1.3.27

Inhibitors

Inhibitors Comment Organism Structure
(1R,4R,5S,6S)-4-[(1-carboxyethenyl)oxy]-5-hydroxy-7-oxabicyclo[4.1.0]hept-2-ene-2-carboxylic acid
-
 Serratia marcescens
(3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carboxylic acid
-
 Serratia marcescens
(3R,4R)-3-azido-4-hydroxycyclohexa-1,5-diene-1-carboxylic acid
-
 Serratia marcescens
(3R,4R)-3-[(1-carboxyethenyl)oxy]-4-hydroxy-6-methylidenecyclohex-1-ene-1-carboxylic acid
-
 Serratia marcescens
(3R,4R)-3-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid
-
 Serratia marcescens
(3S)-3-[(1-carboxyethenyl)oxy]cyclohepta-1,6-diene-1-carboxylic acid
-
 Serratia marcescens
(4R,5R)-5-(carboxymethoxy)-4-hydroxycyclohex-1-ene-1-carboxylic acid
-
 Serratia marcescens
(4R,5R)-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid
-
 Serratia marcescens
(4R,5R)-5-[(1R)-1-carboxyethoxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid
-
 Serratia marcescens
(4R,5R)-5-[(1S)-1-carboxyethoxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid
-
 Serratia marcescens
(4R,5R)-5-[(2-carboxyprop-2-en-1-yl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid
-
 Serratia marcescens
1-(1-carboxyethyl)-2-oxo-1,2-dihydropyridine-4-carboxylic acid
-
 Serratia marcescens
1-(1-carboxyethyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid
-
 Serratia marcescens
1-(2-carboxyprop-2-en-1-yl)-2-oxo-1,2-dihydropyridine-4-carboxylic acid
-
 Serratia marcescens
1-(2-carboxyprop-2-en-1-yl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid
-
 Serratia marcescens
1-(carboxymethyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid
-
 Serratia marcescens
2-amino-3-(1-carboxyethoxy)benzoic acid
-
 Serratia marcescens
2-[(1-carboxyethyl)amino]pyridine-4-carboxylic acid
-
 Serratia marcescens
2-[(carboxymethyl)amino]pyridine-4-carboxylic acid
-
 Serratia marcescens
2-[[(1R,6R)-3-bromo-6-hydroxycyclohexa-2,4-dien-1-yl]oxy]prop-2-enoic acid
-
 Serratia marcescens
3-(1-carboxyethoxy)-2-hydroxybenzoic acid
-
 Serratia marcescens
3-(1-carboxyethoxy)-2-nitrobenzoic acid
-
 Serratia marcescens
3-(1-carboxyethoxy)-4,5-dihydroxybenzoic acid
-
 Serratia marcescens
3-(1-carboxyethoxy)-4-(hydroxymethyl)benzoic acid
-
 Serratia marcescens
3-(1-carboxyethoxy)-4-(sulfanylmethyl)benzoic acid
-
 Serratia marcescens
3-(1-carboxyethoxy)-4-hydroxybenzoic acid
-
 Serratia marcescens
3-(1-carboxyethoxy)-4-methoxybenzoic acid
-
 Serratia marcescens
3-(1-carboxyethoxy)-4-methylbenzoic acid
-
 Serratia marcescens
3-(1-carboxyethoxy)benzoic acid
-
 Serratia marcescens
3-[(1-carboxyethenyl)oxy]-4,5-dihydroxybenzoic acid
-
 Serratia marcescens
3-[(2-carboxyprop-2-en-1-yl)oxy]-4,5-dihydroxybenzoic acid
-
 Serratia marcescens
4-(azidomethyl)-3-(1-carboxyethoxy)benzoic acid
-
 Serratia marcescens
4-amino-3-(1-carboxyethoxy)benzoic acid
-
 Serratia marcescens
4-amino-3-[(1-carboxyethyl)amino]benzoic acid
-
 Serratia marcescens
[(3R,4R)-3-[(1-carboxyethenyl)oxy]-4-hydroxycyclohexa-1,5-dien-1-yl]phosphonate
-
 Serratia marcescens
[4-carboxy-2-(1-carboxyethoxy)phenyl]methanaminium
-
 Serratia marcescens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required for activity Serratia marcescens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
chorismate + L-glutamine Serratia marcescens one subunit of the enzyme contains a chorismate binding site and catalyzes the formation of anthranilate via 2-amino-2-deoxyisochorismate. After the first step, the intermediate remains bound to the enzyme, where it is subsequently converted to anthranilate through the elimination of pyruvate anthranilate + pyruvate + L-glutamate
-
 ?

Organism

Organism UniProt Comment Textmining
Serratia marcescens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
chorismate + L-glutamine one subunit of the enzyme contains a chorismate binding site and catalyzes the formation of anthranilate via 2-amino-2-deoxyisochorismate. After the first step, the intermediate remains bound to the enzyme, where it is subsequently converted to anthranilate through the elimination of pyruvate Serratia marcescens anthranilate + pyruvate + L-glutamate
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.028
-
 3-(1-carboxyethoxy)-4,5-dihydroxybenzoic acid pH and temperature not specified in the publication Serratia marcescens
0.03
-
 3-(1-carboxyethoxy)-4-hydroxybenzoic acid pH and temperature not specified in the publication Serratia marcescens
0.03
-
 (3S)-3-[(1-carboxyethenyl)oxy]cyclohepta-1,6-diene-1-carboxylic acid pH and temperature not specified in the publication Serratia marcescens
0.09
-
 3-[(2-carboxyprop-2-en-1-yl)oxy]-4,5-dihydroxybenzoic acid pH and temperature not specified in the publication Serratia marcescens
0.23
-
 3-[(1-carboxyethenyl)oxy]-4,5-dihydroxybenzoic acid pH and temperature not specified in the publication Serratia marcescens
0.29
-
 (4R,5R)-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid pH and temperature not specified in the publication Serratia marcescens