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Literature summary for 4.1.3.27 extracted from
- Purification and properties of anthranilate synthetase from the ergot fungus, Claviceps spec., strain SD 58 (1977), Lloydia, 40, 136-145.
General Stability
| General Stability | Organism |
|---|---|
| anthranilate synthetase activity of the enzyme complex is quite unstable unless Gln, MgCl2, Tris and glycerol are included in the extraction buffer | Claviceps sp. |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| elymoclavine | i.e. (6-methyl-8,9-didehydroergolin-8yl)methanol | Claviceps sp. |  |
| L-Trp | - |
Claviceps sp. | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.009 | - |
chorismate | - |
Claviceps sp. | |
| 10 | - |
Gln | - |
Claviceps sp. | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 200000 | - |
three-enzyme complex containing anthranilate synthetase, phosphoribosyl anthranilate isomerase and indole-3-glycerol phosphate synthetase, sucrose density gradient centrifugation | Claviceps sp. |
| 400000 | - |
three-enzyme complex containing anthranilate synthetase, phosphoribosyl anthranilate isomerase and indole-3-glycerol phosphate synthetase, gel filtration | Claviceps sp. |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Claviceps sp. | - |
- |
- |
| Claviceps sp. | - |
three-enzyme complex containing anthranilate synthetase, phosphoribosyl anthranilate isomerase and indole-3-glycerol phosphate synthetase | - |
| Claviceps sp. SD58 | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Claviceps sp. |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mycelium | - |
Claviceps sp. | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.585 | - |
- |
Claviceps sp. |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| chorismate + L-Gln | - |
Claviceps sp. | anthranilate + pyruvate + L-glutamate | - |
? | |
| chorismate + L-Gln | - |
Claviceps sp. SD58 | anthranilate + pyruvate + L-glutamate | - |
? | |
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