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Literature summary for 4.1.3.17 extracted from
- Activation of Pseudomonas ochraceae 4-hydroxy-4-methyl-2-oxoglutarate aldolase by inorganic phosphate (1990), J. Biochem., 10, 334-340.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| phosphate | activates | Pseudomonas straminea |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| HgCl2 | 0.1 mM, 41% inhibition | Pseudomonas straminea | |
| NEM | 1 mM, 10% inhibition | Pseudomonas straminea | |
| PCMB | 1 mM, 48% inhibition | Pseudomonas straminea | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | metal-requiring aldolase | Pseudomonas straminea |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Pseudomonas straminea | inducible by aromatic carboxylates such as phthalate | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas straminea | - |
- |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 52.6 | - |
- |
Pseudomonas straminea |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-carboxy-4-hydroxy-2-oxoadipate | L-4-carboxy-4-hydroxy-2-oxoadipate or D-4-carboxy-4-hydroxy-2-oxoadipate | Pseudomonas straminea | pyruvate + oxaloacetate | - |
? | |
| 4-Hydroxy-2-oxoglutarate | - |
Pseudomonas straminea | Pyruvate + glyoxylate | - |
? | |
| 4-hydroxy-4-methyl-2-oxoglutarate | - |
Pseudomonas straminea | pyruvate + pyruvate | - |
? | |
| additional information | inducible by aromatic carboxylates such as phthalate | Pseudomonas straminea | ? | - |
? | |
| oxaloacetate | beta-decarboxylation | Pseudomonas straminea | ? | - |
? | |
| pyruvate + pyruvate | - |
Pseudomonas straminea | 4-hydroxy-4-methyl-2-oxoglutarate | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 54 | - |
pH 7.0, 10 min, 50% loss of activity | Pseudomonas straminea |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
54°C, 10 min, 50% loss of activity | Pseudomonas straminea |
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