Literature summary for 4.1.2.B6 extracted from

Han, S.Q.; Ouyang, P.K.; Wei, P.; Hu, Y.
Enzymatic synthesis of (R)-cyanohydrins by a novel (R)-oxynitrilase from Vicia sativa L (2006), Biotechnol. Lett., 28, 1909-1912.

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Organism

Organism	UniProt	Comment	Textmining
Vicia sativa	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
(R)-mandelonitrile = cyanide + benzaldehyde	no activity with aliphatic substrates	Vicia sativa	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
seed	defatted meal	Vicia sativa	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cyanide + 1,3-benzodioxole-5-carbaldehyde	-	Vicia sativa	(2S)-1,3-benzodioxol-5-yl(hydroxy)ethanenitrile	93% yield, 88% enantiomeric excess	?
cyanide + 4-fluorobenzaldehyde	-	Vicia sativa	(2R)-(4-fluorophenyl)(hydroxy)ethanenitrile	97% yield, 91% enantiomeric excess	?
cyanide + 4-methoxybenzaldehyde	-	Vicia sativa	(2R)-hydroxy(4-methoxyphenyl)ethanenitrile	52% yield, 94% enantiomeric excess	?
cyanide + benzaldehyde	-	Vicia sativa	(R)-mandelonitrile	100% yield, 99% enantiomeric excess	?
cyanide + furan-2-carbaldehyde	-	Vicia sativa	(2S)-furan-2-yl(hydroxy)ethanenitrile	96% yield, 97% enantiomeric excess. (S)-configuration is due to the Cahn-Ingold-Prelog rules	?
cyanide + pyridine-3-carbaldehyde	-	Vicia sativa	(2R)-hydroxy(pyridin-3-yl)ethanenitrile	71% yield, 3% enantiomeric excess	?
additional information	no activity with heptanal	Vicia sativa	?	-	?

Synonyms

Synonyms	Comment	Organism
(R)-Oxynitrilase	-	Vicia sativa

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Release 2023.1 (January 2023)