Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.1.2.63 extracted from

  • Mezzar, S.; De Schryver, E.; Asselberghs, S.; Meyhi, E.; Morvay, P.L.; Baes, M.; Van Veldhoven, P.P.
    Phytol-induced pathology in 2-hydroxyacyl-CoA lyase (HACL1) deficient mice. Evidence for a second non-HACL1-related lyase (2017), Biochim. Biophys. Acta Mol. Cell Biol. Lipids, 1862, 972-990 .
    View publication on PubMed
Search for more literature for 4.1.2.63

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome
-
 Mus musculus 5777
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-hydroxyphytanoyl-CoA Mus musculus
-
 pristanal + formyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9QXE0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
hepatocyte
-
 Mus musculus
-
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-hydroxyoctadecanoyl-CoA
-
 Mus musculus heptadecanal + formyl-CoA
-
 ?
2-hydroxyphytanoyl-CoA
-
 Mus musculus pristanal + formyl-CoA
-
 ?

Subunits

Subunits Comment Organism
homotetramer 4 * 60000, calculated from amino acid sequence Mus musculus

Synonyms

Synonyms Comment Organism
2-hydroxyacyl-CoA lyase
-
 Mus musculus
HACL1
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
thiamine diphosphate
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme deficiency is not associated with a severe phenotype, but in combination with phytanic acid intake it might present with phytanic acid elevation and resemble a Refsum like disorder Mus musculus