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Literature summary for 4.1.2.63 extracted from

  • Casteels, M.; Sniekers, M.; Fraccascia, P.; Mannaerts, G.P.; Van Veldhoven, P.P.
    The role of 2-hydroxyacyl-CoA lyase, a thiamin pyrophosphate-dependent enzyme, in the peroxisomal metabolism of 3-methyl-branched fatty acids and 2-hydroxy straight-chain fatty acids (2007), Biochem. Soc. Trans., 35, 876-880 .
    View publication on PubMed
Search for more literature for 4.1.2.63

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome
-
 Rattus norvegicus 5777
-
peroxisome
-
 Homo sapiens 5777
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Rattus norvegicus
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-hydroxyphytanoyl-CoA Rattus norvegicus
-
 pristanal + formyl-CoA
-
 ?
2-hydroxyphytanoyl-CoA Homo sapiens
-
 pristanal + formyl-CoA
-
 ?
a 2-hydroxy-3-methyl-Cn-fatty-acyl-CoA Rattus norvegicus
-
 a 2-methyl-branched Cn-1-fatty aldehyde + formyl-CoA
-
 ?
a 2-hydroxy-3-methyl-Cn-fatty-acyl-CoA Homo sapiens
-
 a 2-methyl-branched Cn-1-fatty aldehyde + formyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UJ83
-
-
Rattus norvegicus Q8CHM7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-hydroxyoctadecanoyl-CoA
-
 Rattus norvegicus heptadecanal + formyl-CoA
-
 ?
2-hydroxyoctadecanoyl-CoA
-
 Homo sapiens heptadecanal + formyl-CoA
-
 ?
2-hydroxyphytanoyl-CoA
-
 Rattus norvegicus pristanal + formyl-CoA
-
 ?
2-hydroxyphytanoyl-CoA
-
 Homo sapiens pristanal + formyl-CoA
-
 ?
a 2-hydroxy-3-methyl-Cn-fatty-acyl-CoA
-
 Rattus norvegicus a 2-methyl-branched Cn-1-fatty aldehyde + formyl-CoA
-
 ?
a 2-hydroxy-3-methyl-Cn-fatty-acyl-CoA
-
 Homo sapiens a 2-methyl-branched Cn-1-fatty aldehyde + formyl-CoA
-
 ?

Subunits

Subunits Comment Organism
homotetramer 4 * 63000, calculated from amino acid sequence Rattus norvegicus
homotetramer 4 * 63000, calculated from amino acid sequence Homo sapiens

Synonyms

Synonyms Comment Organism
2-HPCL
-
 Rattus norvegicus
2-HPCL
-
 Homo sapiens
2-hydroxyacyl-CoA lyase
-
 Rattus norvegicus
2-hydroxyacyl-CoA lyase
-
 Homo sapiens
2-hydroxyphytanoyl-CoA lyase
-
 Rattus norvegicus
2-hydroxyphytanoyl-CoA lyase
-
 Homo sapiens
HACL1
-
 Rattus norvegicus
HACL1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
thiamine diphosphate dependent on Rattus norvegicus
thiamine diphosphate dependent on Homo sapiens