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Literature summary for 4.1.2.50 extracted from

  • McCarty, R.M.; Somogyi, A.; Bandarian, V.
    Escherichia coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase (2009), Biochemistry, 48, 2301-2303.
    View publication on PubMed
Search for more literature for 4.1.2.50

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 gene queD
-

Reaction

Reaction Comment Organism Reaction ID
7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate reaction mechanism, overview Escherichia coli
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-pyruvoyltetrahydropterin + H2O
-
 Escherichia coli 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate
-
 ?
7,8-dihydroneopterin triphosphate + H2O
-
 Escherichia coli 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate
-
 ?
additional information 6-pyruvoyltetrahydropterin can tautomerize to sepiapterin, the hydrate of which undergoes carbon-carbon bond cleavage by an aldolase-like mechanism, followed by a tautomerization, to yield 6-carboxy-5,6,7,8-tetrahydropterin Escherichia coli ?
-
 ?
sepiapterin + H2O
-
 Escherichia coli 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate
-
 ?

Synonyms

Synonyms Comment Organism
6-carboxy-5,6,7,8-tetrahydropterin synthase
-
 Escherichia coli
QueD
-
 Escherichia coli

General Information

General Information Comment Organism
physiological function QueD catalyzes the conversion of 7,8-dihydroneopterin triphosphate to 6-carboxy-5,6,7,8-tetrahydropterin, CPH4. QueD can also convert 6-pyruvoyltetrahydropterin, PPH4, and sepiapterin to CPH4 Escherichia coli